Seo u hlokang ho se tseba ka lefutso la MTHFR

Litaba

• Mefuta e fapaneng ea phetoho ea MTHFR
• Matšoao a phetoho ea MTHFR
• Ho lekoa liphetoho tsa MTHFR
• Kalafo ea mathata a amanang le bophelo bo botle
• Mathata nakong ea bokhachane
• Ho ka etsahala tlatsetso
• Ho nahanoa ka lijo
• Tsela

Re kenyelletsa lihlahisoa tseo re nahanang hore li na le thuso ho babali ba rona. Haeba u reka ka lihokela tse leqepheng lena, re ka fumana khomishene e nyane. Ts'ebetso ea rona ke ena.

MTHFR ke eng?

Mohlomong u kile ua bona khutsufatso ea "MTHFR" e hlaha litabeng tsa morao-rao tsa bophelo bo botle. E kanna ea shebahala joalo ka thohako qalong, empa ha e le hantle e bua ka phetoho e tloaelehileng ea lefutso.

MTHFR e emetse methylenetetrahydrofolate reductase. E fumana tlhokomelo ka lebaka la phetoho ea liphatsa tsa lefutso e ka lebisang maemong a phahameng a homocysteine ​​maling le maemong a tlase a folate le livithamine tse ling.

Ho bile le ngongoreho ea hore litaba tse ling tsa bophelo bo botle li amahanngoa le liphetoho tse bang teng liphetohong tsa MTHFR, ka hona, liteko li se li atile ho feta lilemo.

Mefuta e fapaneng ea phetoho ea MTHFR

U ka ba le phetoho e le 'ngoe kapa tse peli - kapa che - liphatseng tsa MTHFR. Liphetoho tsena hangata li bitsoa tse fapaneng. Mofuta o mong ke karolo ea DNA ea lefutso eo hangata e fapaneng, kapa e fapaneng, ho tloha ho motho ho ea ho motho.

Ho ba le phapang e le 'ngoe - heterozygous - ho na le monyetla o fokolang oa ho kenya letsoho litabeng tsa bophelo bo botle. Batho ba bang ba lumela hore ho ba le liphetoho tse peli - homozygous - ho ka baka mathata a tebileng le ho feta. Ho na le mefuta e 'meli, kapa mefuta, ea liphetoho tse ka bang teng liphatseng tsa MTHFR.

Mefuta e ikhethileng ke:

• EA-C677T. Hoo e ka bang liperesente tse 30 ho isa ho tse 40 tsa batho ba Amerika ba kanna ba fetoha liphatseng tsa lefutso EA-C677T. Hoo e ka bang liperesente tse 25 tsa batho ba leloko la Masepanishe, le liperesente tse 10 ho isa ho tse 15 tsa litloholo tsa Caucasus, ba homozygous bakeng sa mofuta ona.
• A1298C. Ho na le lipatlisiso tse fokolang mabapi le mofuta ona. Boithuto bo fumanehang ka kakaretso bo ipapisitse le tikoloho kapa morabe. Mohlala, phuputso ea 2004 e shebile ho bafani ba mali ba 120 ba lefa la Ireland. Ho bafani, 56, kapa liperesente tsa 46.7, e ne e le heterozygous bakeng sa mofuta ona, mme 11, kapa liperesente tsa 14.2, e ne e le homozygous.
• Hape hoa khoneha ho fumana liphetoho tse peli tsa C677T le A1298C, e leng kopi e le 'ngoe ea tsona.

Liphetoho tsa lefutso li futsitsoe, ho bolelang hore o li fumana ho batsoali ba hau. Nakong ea kemolo u fumana kopi e le 'ngoe ea lefutso la MTHFR ho motsoali ka mong. Haeba ka bobeli li na le liphetoho, kotsi ea hau ea ho ba le phetoho ea homozygous e phahame.

Matšoao a phetoho ea MTHFR

Matšoao a fapana ho ea ka batho le ho fapana ho fapana. Haeba u etsa patlo e potlakileng ea inthanete, mohlomong u tla fumana libaka tse ngata tsa marang-rang tse reng MTHFR e baka maemo a 'maloa ka kotloloho.

Hopola hore lipatlisiso tse mabapi le MTHFR le litlamorao li ntse li fetoha. Bopaki bo hokahanyang boholo ba maemo ana a bophelo bo botle le MTHFR ha boa fumaneha kapa ha boa amoheloa.

Ho feta moo, ntle le haeba u ka ba le mathata kapa u entsoe liteko, ha ho mohla u tla tseba boemo ba hau ba phetoho ea MTHFR.

Maemo a hlahisitsoeng hore a amahanngoe le MTHFR a kenyelletsa:

• mafu a pelo le methapo (haholo-holo mali, ho otloa ke pelo, ho itšireletsa le lefu la pelo)
• ho tepella maikutlo
• ho tšoenyeha
• ho ferekana kelellong
• schizophrenia
• mofetše oa mala
• leukemia e matla
• bohloko bo sa foleng le mokhathala
• bohloko ba methapo
• migraine
• ho senyeheloa ke maikutlo khafetsa ho basali ba lilemo tsa ho ba le bana
• Bokhachane bo nang le bokooa ba methapo ea methapo, joalo ka mokokotlo oa mokokotlo le anencephaly

Ithute haholoanyane ka ho ba le bokhachane bo atlehileng le MTHFR.

Kotsi e kanna ea eketseha haeba motho a na le mefuta e 'meli ea liphatsa tsa lefutso kapa a le homozygous bakeng sa phetoho ea MTHFR.

Ho lekoa liphetoho tsa MTHFR

Mekhatlo e fapaneng ea bophelo bo botle - ho kenyeletsoa American College of Obstetricians and Gynecologists, College of American Pathologists, American College of Medical Genetics, le American Heart Association - ha e khothaletse liteko tsa mefuta e fapaneng ntle le haeba motho le eena a na le maemo a phahameng haholo a homocysteine ​​kapa lipontšo tse ling tsa bophelo bo botle.

Leha ho le joalo, o kanna oa ba le tjantjello ea ho tseba boemo ba hau ba MTHFR ka bomong. Nahana ka ho etela ngaka ea hau le ho bua ka melemo le mathata a ho hlahlojoa.

Hopola hore liteko tsa lefutso li kanna tsa se koaheloe ke inshorense ea hau. Letsetsa motho ea u tsamaisang haeba u ntse u nahana ho ea hlahlojoa ho botsa ka litšenyehelo.

Lik'hemik'hale tse ling tsa lapeng tsa tlhahlobo ea liphatsa tsa lefutso li fana ka tlhahlobo ea MTHFR hape. Mehlala e kenyelletsa:

• 23andMe ke khetho e tsebahalang e fanang ka leseli la lefutso le tlhaiso-leseling ea bophelo bo botle. E boetse e batla e sa bitse chelete e ngata ($ 200). Ho etsa tlhahlobo ena, o kenya mathe ka har'a tube ebe o e romela ka poso ho laborateng. Liphetho li nka libeke tse tšeletseng ho isa ho tse robeli.
• Lehae la ka la MTHFR ($ 150) ke khetho e 'ngoe e shebaneng haholo le phetoho. Teko e etsoa ka ho bokella DNA ho tsoa kahare ea lerama la hau ka li-swabs. Kamora ho tsamaisa mohlala, liphetho li nka beke e le 'ngoe ho isa ho tse peli.

Kalafo ea mathata a amanang le bophelo bo botle

Ho ba le phapang ea MTHFR ha ho bolele hore o hloka kalafo ea bongaka. Ho ka bolela feela hore o hloka ho nka tlatsetso ea vithamine B.

Kalafo e hlokahala hangata ha o na le maemo a phahameng haholo a homocysteine, hangata ho feta maemo a bakoang ke mefuta e mengata ea MTHFR. Ngaka ea hau e lokela ho fana ka mabaka a mang a bakoang ke ho eketseha ha homocysteine, e ka hlahang ka mefuta e meng ea MTHFR kapa ntle le eona.

Lisosa tse ling tsa homocysteine ​​e phahameng li kenyelletsa:

• hypothyroidism
• maemo a kang lefu la tsoekere, k'holeseterole e phahameng le khatello e phahameng ea mali
• botenya le ho se sebetse
• meriana e meng, e kang atorvastatin, fenofibrate, methotrexate le nicotinic acid

Ho tloha moo, kalafo e tla itšetleha ka sesosa mme ha e hlile ha e nahane ka MTHFR. Mokhelo ke ha u fumanoe u e-na le maemo ana a latelang ka nako e le 'ngoe:

• maemo a phahameng a homocysteine
• phetoho e netefalitsoeng ea MTHFR
• khaello ea vithamine ho folate, choline, kapa livithamini B-12, B-6, kapa riboflavin

Maemong ana, ngaka ea hau e ka fana ka tlhahiso ea tlatsetso ho sebetsana le bofokoli hammoho le meriana kapa kalafo ho sebetsana le boemo bo itseng ba bophelo bo botle.

Batho ba nang le liphetoho liphetohong tsa MTHFR le bona ba ka lakatsa ho nka mehato ea thibelo ho theola maemo a bona a homocysteine. Mokhoa o mong oa thibelo ke ho fetola mekhoa e meng ea bophelo, e ka thusang ntle le ts'ebeliso ea meriana. Mehlala e kenyelletsa:

• ho khaotsa ho tsuba, haeba u tsuba
• ho ikoetlisa ka ho lekaneng
• ho ja phepo e nepahetseng, e leka-lekaneng

Mathata nakong ea bokhachane

Ho senyeheloa ke maikutlo khafetsa le liphoso tsa methapo ea methapo li ka amanang le MTHFR. Setsi sa Boitsebiso ba Mafu le Rare maloetse se re liphuputso li bontša hore basali ba nang le mefuta e 'meli ea C677T ba kotsing e kholo ea ho ba le ngoana ea nang le bothata ba methapo ea methapo.

Phuputso ea 2006 e shebile basali ba nang le nalane ea ho senyeheloa hangata. E fumane hore liperesente tsa 59 tsa tsona li na le liphetoho tse ngata tsa lefutso tsa homozygous, ho kenyeletsoa MTHFR, e amanang le ho hoama ha mali, ha ho bapisoa le liperesente tse 10 tsa basali ba leng sehlopheng sa taolo.

Bua le ngaka ea hau ka liteko haeba ho na le maemo a latelang a u amang:

• U bile le maiphihlelo a 'maloa a ho senyeheloa a sa hlaloseheng.
• U bile le ngoana ea nang le sekoli sa methapo ea methapo.
• Ua tseba hore u na le phetoho ea MTHFR, 'me u imme.

Le hoja ho na le bopaki bo fokolang ba ho e tšehetsa, lingaka tse ling li fana ka maikutlo a ho noa meriana e thibang mali. Tlatsetso ea folate e kanna ea khothaletsoa.

Ho ka etsahala tlatsetso

Phetoho ea lefutso ea MTHFR e thibela tsela eo 'mele o sebelisang folic acid le livithamini tse ling tsa bohlokoa tsa B. Ho fetola tlatsetso ea limatlafatsi tsena ke sepheo se ka bang teng ho loants'eng litlamorao tsa sona.

Folic acid ha e le hantle ke mofuta o entsoeng ke motho, phepo e itlhahelang feela ka tlhaho e fumanoang lijong. Ho nka mofuta o sa fumaneheng oa folate - methylated folate - ho ka thusa mmele oa hau ho o amohela habonolo.

Batho ba bangata ba khothaletsoa ho nka multivitamin e nang le bonyane limiligrama tse 0,4 tsa folic acid letsatsi ka leng.

Bakhachane ha ba khothaletsoe ho chencha livithamini tsa bakhachane kapa tlhokomelo ho latela boemo ba bona ba MTHFR feela. Sena se bolela ho nka tekanyetso e tloaelehileng ea limiligrama tse 0,6 tsa folic acid letsatsi le leng le le leng.

Basali ba nang le nalane ea liphoso tsa methapo ea methapo ba lokela ho bua le ngaka ea bona bakeng sa likhothaletso tse ikhethang.

Li-multivitamine tse nang le methylated folate li kenyelletsa:

• Thorne Basic Nutrients 2 / Letsatsi
• Li-Smarty Pants Batho ba baholo ba felletse
• Li-vithamine tsa 'Mè Nonyana

Bua le ngaka ea hau pele u fetola livithamini le li-supplement. Tse ling li ka kena-kenana le meriana e meng kapa liphekolo tseo u li fumanang.

Ngaka ea hau e kanna ea fana ka tlhahiso ea livithamini tsa ngaka tse nang le folate le folic acid. Ho ipapisitsoe le inshorense ea hau, litšenyehelo tsa likhetho tsena li ka fapana ha li bapisoa le mefuta e fetang ea li-counter.

Ho nahanoa ka lijo

Ho ja lijo tse nang le phepo e ntle ho ka thusa ka tlhaho ho ts'ehetsa maemo a hau a vithamine ena ea bohlokoa. Leha ho le joalo, tlatsetso e ntse e ka hlokahala.

Lijo tse nepahetseng li kenyelletsa:

• liprotheine tse kang linaoa tse phehiloeng, lierekisi le lensisi
• meroho e kang spinach, asparagus, lettuce, li-beet, broccoli, poone, limela tsa Brussels le bok choy
• litholoana tse kang cantaloupe, mahe a linotši, banana, tse tala, litholoana tsa morara le fragole
• maro a kang lamunu, phaenapole e entsoeng ka makotikoting, litholoana tsa morara, tamati kapa lero le leng la meroho
• peanut butter
• peo ea soneblomo

Batho ba nang le liphetoho tsa MTHFR ba kanna ba batla ho qoba lijo tse nang le mofuta oa maiketsetso oa folate, folic acid - leha bopaki bo sa hlaka hore hoa hlokahala kapa ho molemo.

Etsa bonnete ba hore o sheba mabitso, kaha vithamine ena e eketsoa lithollo tse ngata tse ruileng, joalo ka pasta, lijo-thollo, bohobe le phofo e hlahisoang ka thekiso.

Ithute haholoanyane ka phapang lipakeng tsa folate le folic acid.

Tsela

Boemo ba hau ba MTHFR bo kanna ba ama bophelo ba hau kapa bo ke ke ba bo ama. Ho hlokahala lipatlisiso tse ling ho fumana tšusumetso ea 'nete, haeba e teng, e amanang le mefuta-futa.

Hape, mekhatlo e mengata e hlomphuoang ea bophelo bo botle ha e khothaletse tlhahlobo ea phetoho ena, haholoholo ntle le matšoao a mang a bongaka. Bua le ngaka ea hau ka melemo le likotsi tsa tlhahlobo, hammoho le lintho tse ling tse u tšoenyang tseo u ka bang le tsona.

Tsoela pele ho ja hantle, ho ikoetlisa le ho itloaetsa mekhoa e meng ea bophelo bo botle ho ts'ehetsa bophelo ba hau ka kakaretso.