Lefu la Carcinoid

Carcinoid syndrome ke sehlopha sa matšoao a amanang le lihlahala tsa carcinoid. Tsena ke lihlahala tsa mala a manyane, mala, sehlomathiso le methapo ea bronchial matšoafong.

Carcinoid syndrome ke mohlala oa matšoao ao ka linako tse ling a bonoang ho batho ba nang le lihlahala tsa carcinoid. Lihlahala tsena ha li fumanehe hangata 'me hangata lia hola butle. Boholo ba lihlahala tsa kankere li fumanoa ka mpeng le ka matšoafong.

Lefu la Carcinoid le hlaha ho batho ba fokolang haholo ba nang le lihlahala tsa carcinoid, kamora hore hlahala e namele ho sebete kapa matšoafo.

Lihlahala tsena li ntša hormone ea serotonin e ngata haholo, hammoho le lik'hemik'hale tse ling tse 'maloa. Lihormone li etsa hore methapo ea mali e bulehe. Sena se baka lefu la carcinoid.

Lefu la carcinoid le entsoe ka matšoao a mane a mantlha ho kenyelletsa:

• Ho ruruha (sefahleho, molala, kapa sefubeng se kaholimo), joalo ka methapo ea mali e atolohileng e bonoang letlalong (telangiectasias)
• Ho phefumoloha ho thata, joalo ka ho hema
• Letšollo
• Mathata a pelo, joalo ka ho tsoa hoa li-valve tsa pelo, ho otla ha pelo butle, khatello e tlase kapa e phahameng ea mali

Matšoao ka linako tse ling a tlisoa ke ho ikoetlisa, kapa ho ja kapa ho noa lintho tse kang chisi e putsoa, ​​chokolete kapa veine e khubelu.

Boholo ba lihlahala tsena li fumanoa ha liteko kapa lits'ebetso li etsoa ka mabaka a mang, joalo ka nakong ea ts'ebetso ea mpa.

Haeba tlhahlobo ea 'mele e etsoa, ​​mofani oa tlhokomelo ea bophelo a ka fumana matšoao a:

• Mathata a li-valve tsa pelo, joalo ka ho korotla
• Lefu la khaello ea Niacin (pellagra)

Liteko tse ka etsoang li kenyelletsa:

• Maemo a 5-HIAA ka morong
• Liteko tsa mali (ho kenyeletsoa le serotonin le teko ea mali ea chromogranin)
• Tlhatlhobo ea CT le MRI ea sefuba kapa mpa
• Echocardiogram
• Octreotide radiolabeled scan

Ho buoa ho tlosa hlahala hangata ke eona kalafo ea pele. E ka folisa boemo ka ho sa feleng haeba hlahala e tlosoa ka botlalo.

Haeba hlahala e nametse sebeteng, kalafo e kenyelletsa e 'ngoe ea tse latelang:

• Ho tlosa libaka tsa sebete tse nang le lisele tsa hlahala
• Ho romella (ho kenya) moriana ka kotlolloho sebeteng ho senya lihlahala

Ha hlahala eohle e sa khone ho tlosoa, ho tlosa likarolo tse kholo tsa hlahala ("debulking") ho ka thusa ho kokobetsa matšoao.

Liente tsa Octreotide (Sandostatin) kapa lanreotide (Somatuline) li fuoa batho ba nang le lihlahala tse tsoetseng pele tsa carcinoid tse ke keng tsa tlosoa ka ho buuoa.

Batho ba nang le lefu la carcinoid ba lokela ho qoba joala, lijo tse kholo, le lijo tse nang le tyramine e ngata (chisi e seng e tsofetse, avocado, lijo tse ngata tse entsoeng), hobane li ka baka matšoao.

Meriana e meng e tloaelehileng, joalo ka serotonin reuptake inhibitors (SSRIs) e khethiloeng, joalo ka paroxetine (Paxil) le fluoxetine (Prozac), e ka mpefatsa matšoao ka ho eketsa serotonin. Leha ho le joalo, U SE KE UA emisa ho noa meriana ena ntle le haeba mofani oa thepa a u joetsa joalo.

Ithute haholoanyane ka lefu la carcinoid mme o fumane tšehetso ho:

• Motheo oa Kankere ea Carcinoid - www.carcinoid.org/resource/support-groups/directory/
• Setsi sa Patlisiso ea Neuroendocrine Tumor - netrf.org/for-patients/

Pono ea batho ba nang le lefu la carcinoid ka linako tse ling e fapane le pono ea batho ba nang le lihlahala tsa kankere ntle le lefu lena.

Phatlalatso e boetse e latela sebaka sa hlahala. Ho batho ba nang le lefu lena, hangata hlahala e hasana ho ea sebeteng. Sena se theola sekhahla sa pholoho. Batho ba nang le lefu la carcinoid le bona ba na le monyetla oa ho ba le mofetše o arohaneng (hlahala ea bobeli ea mantlha) ka nako e le ngoe. Ka kakaretso, ho phatlalatsoa hangata ho ntle haholo.

Mathata a lefu la kankere a ka kenyelletsa:

• Kotsi e eketsehileng ea ho oa le kotsi (ho tloha khatello e tlase ea mali)
• Tšitiso ea mala (ho tsoa hlahala)
• Ho tsoa mali ka mpeng
• Ho hloleha ha valve ea pelo

Mofuta o bolaeang oa lefu la kankere, bothata ba lefu la kankere, o ka hlaha e le litlamorao tsa ho buuoa, ho thethebatsoa kapa chemotherapy.

Ikopanye le mofani oa hau bakeng sa kopano haeba u na le matšoao a lefu la carcinoid.

Ho phekola hlahala ho fokotsa menyetla ea lefu la carcinoid.

Lefu la Flush; Lefu la Argentaffinoma

• Ho nkuoa ha Serotonin

Webosaete ea National Cancer Institute. Kalafo ea lihlahala tsa ka mpeng ea motho ea ka mpeng (Motho e moholo) (PDQ) - mofuta oa litsebi tsa bophelo bo botle. www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid- kalafo-pdq. E ntlafalitsoe ka Loetse 16, 2020. E fihlile ka la 14 Mphalane 2020.

Öberg K. Neuroendocrine lihlahala le mathata a amanang le ona. Ka: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, bangoli. Buka ea Williams ea Endocrinology. La bo14 la ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 45.

Wolin EM, Jensen RT. Lihlahala tsa Neuroendocrine. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 219.