Tataiso ea hau ho Anti-Androgens

Litaba

• Li sebelisoa joang?
• Bakeng sa basali
• Bakeng sa basali ba li-transgender le batho ba sa sebetseng
• Bakeng sa banna
• Tse ling tsa tse tloaelehileng ke life?
• Flutamide
• Spironolactone
• Cyproterone
• Litla-morao ke life?
• Ntlha ea bohlokoa

Li-anti-androgens ke eng?

Androgens ke lihormone tse laolang kholo ea likarolo tsa thobalano. Ka tloaelo, batho ba tsoetsoeng ba na le litšobotsi tsa thobalano tsa banna ba na le li-androgens tse phahameng. Batho ba tsoetsoeng ba na le litšobotsi tsa basali ba na le maemo a tlase a androgens. Sebakeng seo, li na le maemo a phahameng a li-estrogen.

Lithethefatsi tse khahlanong le androgen li sebetsa ka ho thibela litlamorao tsa li-androgens, joalo ka testosterone. Ba etsa sena ka ho tlama liprotheine tse bitsoang li-receptor tsa androgen. Li tlama li-receptor tsena hore li-androgens li se ke tsa khona.

Hona le mefuta e mengata ea li-anti-androgens. Hangata li nooa ka meriana e meng kapa nakong ea ts'ebetso e itseng ea ho buoa.

Li sebelisoa joang?

Li-anti-androgens li na le ts'ebeliso e ngata, ho tloha ho laoleng mofetše oa tšoelesa ea senya ho fokotsa moriri o sa batleheng oa sefahleho.

Bakeng sa basali

Basali bohle ka tlhaho ba hlahisa li-androgens tse nyane. Leha ho le joalo, basali ba bang ba hlahisa ho feta ba bang.

Mohlala, basali ba nang le polycystic ovary syndrome (PCOS) ba na le maemo a phahameng a androgen. Sena se ka baka kholo ea kholo ea moriri, makhopho le makhopho. Li-anti-androgens li ka thusa ho fokotsa matšoao ana ho basali ba nang le PCOS.

Maemo a mang a bakang li-androgens tse phahameng ho basali a kenyelletsa:

• adrenal hyperplasia
• lihlahala tsa mae a bomme
• lihlahala tsa adrenal gland

Li-anti-androgens li ka thusa ho sebetsana le maemo ana le ho thibela mathata a bakoang ke maemo a phahameng a androgen ho basali. Mathata ana a kenyelletsa:

• lefu la tsoekere
• cholesterol e phahameng
• khatello e phahameng ea mali
• lefu la pelo

Bakeng sa basali ba li-transgender le batho ba sa sebetseng

Bakeng sa batho ba fetohileng, li-anti-androgens li ka thusa ho thibela tse ling tsa litlamorao tsa testosterone. Li ka fokotsa litšobotsi tse ling tsa banna, tse kang:

• lefatla la monna
• kholo ea moriri oa sefahleho
• litokisetso tsa hoseng

Li-anti-androgens li sebetsa haholo ho basali ba iphetotseng bong ha ba nooa ka estrogen, hormone ea mantlha ea thobalano ea basali. Ntle le ho tsosa kholo ea litšobotsi tsa basali tse kang matsoele, estrogen e boetse e fokotsa maemo a testosterone ka tsela e sa tobang. Ho nka li-anti-androgens ka estrogen ho ka thusa ho hatella mekhoa ea banna le ho khothaletsa tse tšehali.

Bakeng sa batho ba khethollang e se tse sa tloaelehang, ho nka li-anti-androgens feela ho ka thusa ho fokotsa litšobotsi tsa banna.

Bakeng sa banna

Androgens e hlohlelletsa kholo ea lisele tsa mofets'e ho prostate. Ho theola maemo a androgen, kapa ho thibela li-androgens ho fihlela lisele tsa mofetše, ho ka thusa ho fokotsa mofetše. E kanna ea nyenyefatsa lihlahala tse seng li ntse li le teng.

Boemong ba eona ba pele, lisele tsa mofetše oa senya li ts'epa li-androgens ho fepa kholo ea tsona. Li-anti-androgens li sebetsa ka ho thibela li-androgens hore li se ke tsa tlama ho isa ho li-receptor tsa androgen liseleng tsa mofetše oa senya. Sena se lapisa lisele tsa mofetše tsa li-androgens tseo ba li hlokang hore ba hole.

Leha ho le joalo, li-anti-androgens ha li emise tlhahiso ea androgen. Hangata li sebelisoa hammoho le mekhoa e meng ea kalafo, joalo ka ts'oaetso ea ho buoa kapa ea lik'hemik'hale. Metsoako ena e boetse e bitsoa:

• kopano e kopaneng ea androgen
• thibelo e felletseng ea androgen
• Kakaretso ea thibelo ea androgen

Tse ling tsa tse tloaelehileng ke life?

Ho na le li-anti-androgens tse 'maloa tse fumanehang, e' ngoe le e 'ngoe e sebelisoa hanyane hanyane. Mona ke tse ling tsa tse atileng haholo.

Flutamide

Flutamide ke mofuta oa anti-androgen o sebelisoang le meriana e meng ho alafa mefuta e itseng ea mofetše oa senya. Flutamide e tlama li-receptor tsa androgen ka lisele tsa mofetše oa senya, tse thibelang li-androgens hore li se ke tsa tlama ho li-receptor. Sena se thibela li-androgens ho khothaletsa kholo ea lisele tsa mofetše oa senya.

Spironolactone

Spironolactone (Aldactone) ke mofuta oa anti-androgen o sebeliselitsoeng ho phekola makhopho a li-hormone le moriri o feteletseng oa 'mele. Batho ba fetohang ba ka e nka ho fokotsa litšobotsi tsa bonna. Le ha ho na le bopaki bo fokolang ba ho ts'ehetsa ts'ebeliso ea eona, e fane ka eona bakeng sa lefatla la basali.

Cyproterone

Cyproterone e ne e le e 'ngoe ea li-anti-androgens tsa pele. Ke ka meriana e meng ea ho phekola basali ba nang le PCOS. E boetse e bontšitsoe maemong a testosterone le tlhahiso ea mafura a bakang makhopho.

E kanna ea sebelisoa ho fokotsa litšobotsi tsa banna ho basali ba iphetotseng bong. Leha ho le joalo, ka lebaka la litla-morao tsa eona, ka kakaretso ha e khethoe.

Litla-morao ke life?

Anti-androgens e ka hlahisa litla-morao tse fapaneng, ho latela tekanyetso le mofuta oo u o nkang.

Tse ling tsa litla-morao li ka kenyelletsa:

• koloi e tlase ea thobalano
• kotsi e eketsehileng ea khatello ea maikutlo
• li-enzyme tse phahameng tsa sebete
• moriri o fokolang oa sefahleho le 'mele
• kotsi e kholo ea bofokoli ba tsoalo haeba e nkuoa nakong ea bokhachane
• lefu la sebete
• kotsi ea sebete
• ho se sebetse ha erectile
• letšollo
• bonolo ba matsoele
• mahlasedi a chesang
• ho se tloaelehe ha nako ea ho ilela khoeli
• ho phatloha hoa letlalo
• anti-androgen resistance, ho bolelang hore meriana e emisa ho sebetsa

Ngaka ea hau e ka u thusa ho khetha anti-androgen e loketseng litlhoko tsa hau hantle 'me e tla le litla-morao tse fokolang.

Ntlha ea bohlokoa

Li-anti-androgens li na le ts'ebeliso e ngata bakeng sa banna, basali, le batho phetohong ea bong, ka bobona le ka kopanelo le meriana le kalafo e meng. Leha ho le joalo, li-anti-androgens ke lithethefatsi tse matla tse ka bakang litlamorao tse mpe. Sebetsa le ngaka ea hau ho lekanya melemo le mathata a ho nka li-anti-androgens.