Sengoli: Peter Berry
Letsatsi La Creation: 13 Phupu 2021
Ntlafatsa Letsatsi: 22 December 2024
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Litaba

Hopola tokollo e atolositsoeng ea metformin

Ka Mots'eanong 2020, tlhahiso e khothalelitsoeng hore baetsi ba metformin e atolositsoeng ba tlose tse ling tsa matlapa a bona 'marakeng oa U.S. Lebaka ke hobane boemo bo sa amoheleheng ba kankere ea tlhaho e ka hlahisang kankere bo fumanoe matlapeng a metformin a atolositsoeng. Haeba hajoale o sebelisa sethethefatsi sena, letsetsa mofani oa tlhokomelo ea bophelo ba hau. Ba tla u eletsa hore na u tsoelapele ho noa meriana ea hau kapa haeba u hloka lengolo la ngaka le lecha.

Meriana e mengata, joalo ka li-statins le li-antihistamine tse ling, e na le tšebelisano e mpe le litholoana tsa morara. Metformin e sebelisoa ho phekola lefu la tsoekere la mofuta oa 2.

Na ho ba le litholoana tsa morara ha u ntse u nka metformin ho lebisa litlamong tse mpe? Ho na le lipatlisiso tse fokolang, empa mona ke seo u hlokang ho se tseba.

Metformin ke eng?

Metformin ke sethethefatsi se laetsoeng ho alafa lefu la tsoekere la mofuta oa 2. Batho ba nang le lefu la tsoekere la mofuta oa 2 ba ke ke ba sebelisa insulin ka mokhoa o tloaelehileng. Sena se bolela hore ha ba khone ho laola bongata ba tsoekere maling a bona. Metformin e thusa batho ba nang le lefu la tsoekere la mofuta oa 2 ho laola boemo ba tsoekere maling a bona ka litsela tse ngata, ho kenyelletsa:


  • ho fokotsa palo ea tsoekere eo 'mele oa hau o e monyang lijong
  • ho fokotsa palo ea tsoekere e hlahisoang ke sebete sa hau
  • ho eketsa karabelo ea 'mele oa hau ho insulin eo e e etsang ka tlhaho

Metformin e ka baka boemo bo kotsi haholo le bo sokelang bophelo bo bitsoang lactic acidosis. Batho ba nang le mathata a sebete, liphio kapa pelo ba lokela ho qoba ho nka metformin.

Likamano tsa lithethefatsi le litholoana tsa morara li sebetsa joang

Ho na le tse fetang tse tsejoang hore li sebelisana le tholoana ea morara. Har'a lithethefatsi tsena, ho ka lebisa liphellong tse mpe. Mefuta eohle ea tholoana ea morara - ho kenyeletsoa lero le sa tsoa hatisoa, mohopolo o hoamisitsoeng ke serame le litholoana tsohle - li ka lebisa ho sebelisaneng le lithethefatsi.

Lik'hemik'hale tse ling tse fumanoang morareng oa morara li ka tlama le ho thibela enzyme 'meleng oa hau e fumanoang mala le sebeteng. Enzyme ena e thusa ho theola meriana eo u e nkang.

Ka tloaelo ha u noa sethethefatsi ka molomo, se robeha hanyenyane ke li-enzyme pele se fihla maling a hao. Sena se bolela hore o amohela hanyane ka hanyane moriana o maling a hau ho feta oo o neng o o sebelisa qalong.


Empa ha enzyme e thibetsoe - joalo ka ha e sebelisana le lik'hemik'hale tsa tholoana ea morara - ho na le palo e kholo ea moriana o kenang maling a hau. Sena se lebisa kotsing e kholo ea ho feta tekano. Sheba ka botebo litšebelisano tsa lithethefatsi tsa morara.

Ke lithethefatsi life tse sebelisanang le litholoana tsa morara?

Ho ea ka, mefuta e latelang ea lithethefatsi e ka ba le tšebelisano e mpe le tholoana ea morara:

  • liemahale, joalo ka simvastatin (Zocor) le atorvastatin (Lipitor)
  • lithethefatsi tsa khatello e phahameng ea mali, joalo ka nifedipine (Procardia)
  • lithethefatsi tse itšireletsang mafung, joalo ka cyclosporine (Sandimmune)
  • corticosteroids e sebelisetsoang ho phekola lefu la Crohn kapa ulcerative colitis, joalo ka budesonide (Entocort EC)
  • lithethefatsi tse sebetsanang le morethetho oa pelo o sa tloaelehang, joalo ka amiodarone (Pacerone)
  • antihistamine, e kang fexofenadine (Allegra)
  • lithethefatsi tse ling tse loantšang matšoenyeho, joalo ka buspirone (BuSpar)

Lero la tholoana ea morara ha le na phello moriana o mong le o mong ka mekhahlelo e kaholimo. Ho sebelisana le lero la tholoana ea morara ho totobetse lithethefatsi, eseng sehlopha sa litlhare.


Ha u qala ka meriana e mecha, ho bohlokoa haholo hore u botse ngaka kapa setsebi sa metsoako haeba u khona ho ja tholoana ea morara kapa lihlahisoa tse amanang le morara.

Tholoana ea morara e ama metformin joang?

Ho bohlokoa ho tseba hore metformin ha e robehe ke enzyme e ts'oanang le lithethefatsi tse thathamisitsoeng kaholimo. Ha e sebetsoe ke 'mele oa hau ebile e lelekoa morotong oa hau.

Ho na le tlhaiso-leseling e fokolang mabapi le hore na ho ba le litholoana tsa morara ha u ntse u nka metformin ho ama batho ba nang le lefu la tsoekere la mofuta oa 2.

Ho builoe ka litlamorao tsa tholoana ea morara le metformin ho likhoto tse seng tsa lefu la tsoekere. Likhoto tse ling li ile tsa pepesetsoa lero la litholoana tsa morara le metformin. Ba bang ba ile ba pepesetsoa metformin feela. Bafuputsi ba fumane hore ho na le keketseho ea palo ea tlhahiso ea asiti ea lactic likhoto tse pepeselitsoeng lero la litholoana tsa morara le metformin.

Bafuputsi ba hakanya hore lero la litholoana tsa morara le ntlafalitse pokello ea metformin sebeteng. Sena le sona se bakile keketseho ea tlhahiso ea asiti ea lactic. Ka lebaka la sena, bafuputsi ba khothalelitse hore ho noa lero la litholoana tsa morara ho ka baka kotsi e kholo ea lactic acidosis ho batho ba nkang metformin.

Leha ho le joalo, liphetho tsena li ile tsa bonoa ka likhoto tse sa amaneng le lefu la tsoekere, eseng ho batho ba nang le lefu la tsoekere la mofuta oa 2. Ho fihlela joale, ha ho so be le thuto ea linyeoe bathong e bonts'ang hore ho nka metformin ka lero la litholoana tsa morara ho lebisa ho lactic acidosis.

Lintho tse ling tseo u lokelang ho li qoba ha u le metformin

Ho noa meriana ha u ntse u noa metformin ho ka eketsa menyetla ea ho ba le lactic acidosis. U lokela ho tsebisa ngaka ea hau haeba u noa efe kapa efe ea meriana e latelang:

  • diuretics, joalo ka acetazolamide
  • corticosteroids, joalo ka prednisone
  • meriana ea khatello ea mali, e kang amlodipine (Norvasc)
  • li-anticonvulsants, joalo ka topiramate (Topamax) le zonisamide (Zonegran)
  • lithibela-pelehi tsa molomo
  • Lithethefatsi tse thibelang mafu, joalo ka chlorpromazine

Qoba ho noa joala bo bongata ha o ntse o le metformin. Ho noa joala ha o ntse o nka metformin ho eketsa menyetla ea ho ba le tsoekere e tlase maling kapa le lactic acidosis.

Ho ea ka Univesithi ea Michigan, o lokela ho qoba ho ja lijo tse nang le fiber haholo kamora ho nka metformin. Lebaka ke hore fiber e ka tlama lithethefatsi le ho theola mohopolo oa tsona. Metformin e fokotseha ha e nkoa ka fiber e ngata (e fetang limiligrama tse 30 ka letsatsi).

Litataiso tse ling tsa phepo ea batho ba nang le lefu la tsoekere ke tse latelang:

  • Kenyelletsa lik'habohaedreite tse tsoang meroho, litholoana le lithollo kaofela. Etsa bonnete ba hore o lekola kamohelo ea hau ea k'habohaedreite, hobane sena se tla ama tsoekere ea mali ka kotloloho.
  • Qoba lijo tse nang le mafura a mangata. Ho e-na le hoo, ja mafura a litlhapi, linate le oli ea mohloaare. Mona ke litsela tse 10 tsa ho eketsa mafura a phetseng hantle lijong tsa hau.
  • Ho ja li-milligram tse 25 ho isa ho tse 30 tsa fiber ka letsatsi ho ka thusa ho laola maemo a tsoekere ea mali. Bona lenane lena la lijo tse 22 tse nang le fiber e ngata ho qala.
  • Qoba sodium. Leka ho ja limiligrama tse ka tlase ho 2300 ka letsatsi.

Kamoo litholoana tsa morara li ka thusang batho ba nang le lefu la tsoekere

Ho noa lero la litholoana tsa morara ho ka ba molemo haeba u na le lefu la tsoekere.

E bontšitse hore litokisetso tsa ho noa tsa lero la litholoana tsa morara tse hlakisitsoeng li fokolitse tsoekere e potlakileng le boima ba 'mele. Liphetho tse bonoeng li ne li ts'oana le litlamorao tsa metformin. Ho ne ho se na phello e ntlafetseng ha lero la litholoana tsa morara le metformin li ne li lekoa hammoho.

Ha o ntse o ts'episa, ho bohlokoa ho hlokomela hore maikutlo ana a entsoe ka mohlala oa toeba ea lefu la tsoekere.

Karolo ea karolo ea tholoana ea morara lijong le tšebelisanong ea lithethefatsi e boetse e fana ka maikutlo a hore tholoana ea morara e amahanngoa le ho theola boima ba 'mele le ho ntlafatsa ho hanyetsa insulin. Ho feta moo, tlhahlobo e boetse e tlaleha hore motsoako oa lero la litholoana tsa morara (naringin) o fumanoe o ntlafatsa hyperglycemia le cholesterol e phahameng ka mofuta oa 2 oa liphoofolo tsa lefu la tsoekere. Ithute haholoanyane ka ho phela le lefu la tsoekere le cholesterol e phahameng.

Tsa Tsau-tsau

Morara oa litholoana o lebisa litšebelisanong tse mpe le meriana e meng. Leha ho le joalo, ha ho na liphuputso tse mabapi le ho ja lero la litholoana tsa morara ha o ntse o nka metformin ho lebisitse liphellong tse mpe bathong.

Ho na le bopaki bo ts'episang ba liteko ba hore ho kenyelletsa litholoana tsa morara lijong tsa hau ho ka thusa ho khothaletsa tahlehelo ea boima ba 'mele le ho fokotsa maemo a tsoekere a itima lijo.

Haeba u nka metformin 'me u tšoenyehile ka litšebelisano tsa lithethefatsi kapa lithethefatsi, bua le mofani oa tlhokomelo ea bophelo.

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