Teko ea liphatsa tsa lefutso ea BRCA

Litaba

• Teko ea liphatsa tsa lefutso ea BRCA ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea BRCA?
• Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BRCA?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea liphatsa tsa lefutso ea BRCA?
• Litšupiso

Teko ea liphatsa tsa lefutso ea BRCA ke eng?

Teko ea liphatsa tsa lefutso ea BRCA e sheba liphetoho tse tsejoang e le liphetoho liphatseng tsa lefutso tse bitsoang BRCA1 le BRCA2. Liphatsa tsa lefutso ke likarolo tsa DNA tse fetisitsoeng ho tsoa ho mme le ntate oa hau. Li na le tlhaiso-leseling e khethollang litšobotsi tse ikhethang tsa hau, joalo ka bophahamo le 'mala oa mahlo. Liphatsa tsa lefutso le tsona li ikarabella bakeng sa maemo a itseng a bophelo bo botle. BRCA1 le BRCA2 ke liphatsa tsa lefutso tse sireletsang lisele ka ho etsa liprotheine tse thusang ho thibela lihlahala hore li se ke tsa theha.

Phetoho ea lefutso la BRCA1 kapa BRCA2 e ka baka tšenyo ea sele e ka lebisang ho mofets'e. Basali ba nang le liphatsa tsa lefutso tsa BRCA tse fetotsoeng ba na le kotsi e kholo ea ho tšoaroa ke mofetše oa matsoele kapa oa mae a bomme. Banna ba nang le liphatsa tsa lefutso tse fetotsoeng tsa BRCA ba kotsing e kholo ea ho tšoaroa ke mofetše oa matsoele kapa oa senya. Ha se motho e mong le e mong ea futsitseng phetoho ea BRCA1 kapa BRCA2 ea tla ba le mofetše. Lintlha tse ling, ho kenyelletsa mokhoa oa hau oa bophelo le tikoloho, li ka ama kotsi ea hau ea mofetše.

Haeba o fumana hore o na le phetoho ea BRCA, o kanna oa nka mehato ea ho sireletsa bophelo ba hau.

Mabitso a mang: Teko ea liphatsa tsa lefutso ea BRCA, BRCA liphatsa tsa lefutso 1, mofuta oa BRCA 2, kankere ea matsoele e ka ba bonolo gen1

E sebelisetsoa eng?

Teko ena e sebelisetsoa ho fumana hore na o na le phetoho ea liphatsa tsa lefutso tsa BRCA1 kapa BRCA2. Phetoho ea liphatsa tsa lefutso ea BRCA e ka eketsa menyetla ea ho tšoaroa ke mofetše.

Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea BRCA?

Ho hlahlojoa ha BRCA ha ho khothaletsoe ho batho ba bangata. Liphetoho tsa lefutso tsa BRCA ha li fumanehe hangata, li ama feela liperesente tse 0,2 tsa baahi ba U.S. Empa u kanna ua batla tlhahlobo ena haeba u nahana hore u kotsing e kholo ea ho fetoha. U na le monyetla oa ho ba le phetoho ea BRCA haeba u:

• Na kapa o na le mofetše oa matsoele o fumanoeng pele a le lilemo li 50
• E-ba le kankere ea matsoele matsoeleng ka bobeli
• Ho ba le kankere ea matsoele le ea mahe a mabeli kapa o na le eona
• Ho ba le setho se le seng kapa tse ngata tsa lelapa tse nang le mofetše oa matsoele
• E-ba le mong ka uena ea amanang le kankere ea matsoele
• Ho ba le mong ka uena ea seng a fumanoe a na le phetoho ea BRCA
• Na ke ba leloko la Bajuda ba Ashkenazi (Europe Bochabela). Liphetoho tsa BRCA li atile haholo sehlopheng sena ha li bapisoa le sechaba ka kakaretso. Liphetoho tsa BRCA le tsona li atile haholo bathong ba tsoang likarolong tse ling tsa Europe, ho kenyeletsoa, ​​Iceland, Norway le Denmark.

Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BRCA?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ha o hloke litokisetso tse khethehileng bakeng sa liteko tsa BRCA. Empa o kanna oa batla ho kopana le moeletsi oa liphatsa tsa lefutso pele ho bona hore na tlhahlobo e u loketse. Moeletsi oa hau a ka bua le uena ka likotsi le melemo ea tlhahlobo ea liphatsa tsa lefutso le hore na litholoana tse fapaneng li ka bolela eng.

Hape o lokela ho nahana ka ho fumana tlhabollo ea lefutso kamora 'tlhahlobo ea hau. Moeletsi oa hau a ka bua ka hore na litholoana tsa hau li ka ama uena le ba lelapa la hau joang, ka bongaka le maikutlong.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Liphetho tse ngata li hlalosoa e le tse mpe, tse sa tsitsang, kapa tse ntle, 'me hangata li bolela tse latelang:

• Phello e mpe ho bolela hore ha ho na phetoho ea lefutso ea BRCA e fumanoeng, empa ha ho bolele hore u ke ke ua hlola u tšoaroa ke mofetše.
• Sephetho se sa tsitsang e bolela mofuta o mong oa phetoho ea liphatsa tsa lefutso ea BRCA e fumanoeng, empa e kanna ea hokahanngoa kapa ea se ke ea amahanngoa le kotsi e eketsehileng ea mofets'e. U kanna ua hloka liteko tse ling le / kapa tlhahlobo haeba liphetho tsa hau li sa ts'oanehe.
• Phello e ntle e bolela phetoho ho BRCA1 kapa BRCA2 e fumanoe. Liphetoho tsena li u beha kotsing e kholo ea ho tšoaroa ke mofetše. Empa ha se bohle ba nang le phetoho ba nang le mofetše.

Ho ka nka libeke tse 'maloa ho fumana liphetho. Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo le / kapa moeletsi oa hau oa lefutso.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea liphatsa tsa lefutso ea BRCA?

Haeba liphetho tsa hau li bontša hore u na le phetoho ea liphatsa tsa lefutso tsa BRCA, u ka nka mehato e ka fokotsang kotsi ea mofets'e oa matsoele. Tsena li kenyelletsa:

• Liteko tsa khafetsa tsa tlhahlobo ea mofets'e, joalo ka mammograms le li-ultrasound. Kankere e bonolo ho phekoloa ha e fumanoa mekhahlelong ea pele.
• Ho noa lipilisi tsa thibelo ea bokhachane ka nako e lekanyelitsoeng. Ho noa lipilisi tsa thibelo ea bokhachane ka nako e fetang lilemo tse hlano ho bontšitsoe ho fokotsa kotsi ea mofetše oa mae a bomme ho basali ba bang ba nang le phetoho ea liphatsa tsa lefutso tsa BRCA. Ho noa lipilisi nako e fetang lilemo tse hlano ho fokotsa mofetše ha ho khothaletsoe. Haeba u ne u noa lipilisi tsa pelehi pele u etsa tlhahlobo ea BRCA, bolella mofani oa tlhokomelo ea bophelo hore na u ne u le lilemo li kae ha u qala ho noa lipilisi le hore na u nka nako e kae. Joale o tla khothaletsa hore na o lokela ho tsoelapele ho li noa kapa che.
• Ho nka meriana e loantšang mofets'e. Lithethefatsi tse ling, joalo ka e bitsoang tamoxifen, li bontšitsoe ho fokotsa kotsi ho basali ba nang le kotsi e kholo ea mofets'e oa matsoele.
• Ho etsoa opereishene, e tsejoang e le thibelo ea mastectomy, ho tlosa lisele tsa matsoele tse phetseng hantle. Ho thibela tšoaetso ho bontšitsoe ho fokotsa kotsi ea mofetše oa matsoele ka liperesente tse 90 ho basali ba nang le phetoho ea liphatsa tsa lefutso tsa BRCA. Empa ona ke ts'ebetso e kholo, e khothalletsoang feela bakeng sa basali ba kotsing e kholo ea ho tšoaroa ke mofetše.

U lokela ho bua le mofani oa tlhokomelo ea bophelo ho bona hore na ke mehato efe e u loketseng.

Litšupiso

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2. Hinkle J, Cheever K. Brunner & Suddarth's Handbook ea Liteko tsa Laboraro le Tlhatlhobo. 2nd Ed, mosa. Philadelphia: Wolters Kluwer Bophelo, Lippincott Williams & Wilkins; c2014. Teko ea BRCA; 108 leq.
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Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.