Masole a mmele a monoclonal: ke eng le hore hobaneng a thusa ho phekola mafu

Litaba

• Mehlala ea lithibela-mafu tse monoclonal
• 1. Trastuzumab
• 2. Denosumab
• 3. Obinutuzumab
• 4. Ustequinumab
• 5. Pertuzumab
• Mokhoa oa ho nka li-antibodies tsa monoclonal

Li-antibodies tsa monoclonal ke liprotheine tse sebelisoang ke sesole sa 'mele ho khetholla le ho fokotsa' mele ea kantle ho naha, eo e ka bang libaktheria, livaerase kapa lisele tsa hlahala. Liprotheine tsena li totobetse, joalo ka ha li lemoha sepheo se itseng, se bitsoang antigen, se tla ba teng liseleng tse kantle ho 'mele. Utloisisa hore na immune system e sebetsa joang.

Li-antibodies tsa monoclonal, joalo ka denosumab, obinutuzumab kapa ustequinumab, ka mohlala, li hlahisoa ka laboratoring, hangata li ts'oana le tse fumanoang 'meleng oa motho, tse tla thusa' mele ho loants'a mafu a mang. Kahoo, ho ipapisitse le lesole la mmele le le leng le le leng le sebelisitsoeng, litlhare tsena li ka sebelisoa ho alafa mafu a tebileng a kang lefu la masapo, lefu la kankere ea mali, plaque psoriasis kapa mefuta e meng ea mofetše, joalo ka mofets'e oa matsoele kapa oa masapo.

Mehlala ea lithibela-mafu tse monoclonal

Mehlala e meng ea lithibela-mafu tse monoclonal e kenyelletsa:

1. Trastuzumab

Lesole lena la 'mele le monoclonal, le rekisoang e le Herceptin, le entsoe ke boenjineri ba liphatsa tsa lefutso, mme le hlasela protheine e teng ho batho ba nang le mofetše o itseng oa matsoele le mpeng. Kahoo, pheko ena e bontšoa bakeng sa kalafo ea mofets'e oa matsoele qalong kapa ka metastasis le mofetše oa mpeng nakong e tsoetseng pele.

2. Denosumab

E rekisoa e le Prolia kapa Xgeva, ka sebopeho sa eona e na le lesole la mmele la motho a le mong la IgG2, le sitisang ts'ebetso ea protheine e itseng e matlafatsang masapo, e fokotsang menyetla ea ho robeha. Kahoo, Denosumab e bonts'oa bakeng sa kalafo ea tahlehelo ea masapo, lefu la masapo, mofetše oa masapo kapa mofetše maemong a tsoetseng pele ka metastase ea masapo (e nametseng masapong).

3. Obinutuzumab

E tsejoang hape ka khoebo e le Gazyva, e na le li-antibodies tsa eona tse amohelang le ho itlama ka kotloloho ho protheine ea CD20, e fumanoang holim 'a lisele tse tšoeu tsa mali kapa li-lymphocyte tsa B. Ka hona, obinutuzumab e bonts'oa kalafo ea leukemia e sa foleng ea lymphocytic, joalo ka ha e le joalo. e khonang ho emisa kholo e sa tloaelehang ea lisele tse tšoeu tsa mali tse bakang lefu lena.

4. Ustequinumab

Pheko ena e ka tsebahala hape ka khoebo e le Stelara mme e entsoe ka lesole la motho la IgG1 monoclonal, le thibelang liprotheine tse ikarabellang bakeng sa ho baka psoriasis. Kahoo, pheko ena e bontšoa kalafo ea psoriasis ea plaque.

5. Pertuzumab

E tsejoang hape e le Perjeta, e entsoe ka lithibela-mafu tse monoclonal tse tlamang mokelikeli oa motho oa ho hola ha epidermal factor 2, o teng liseleng tse ling tsa mofets'e, o liehisa kapa o emisa kholo ea ona. Kahoo, Perjeta e bonts'oa kalafo ea mofetše oa matsoele.

Mokhoa oa ho nka li-antibodies tsa monoclonal

Meriana e nang le `` Monoclonal Antibodies '' e lokela ho nkuoa feela tlasa boeletsi ba bongaka, kaha mofuta oa lesole la mmele o lokelang ho sebelisoa le litekanyetso tse khothalletsoang li ipapisitse le bothata bo lokelang ho phekoloa le ho tiea ha eona.

Maemong a mangata, litlhare tsena li sebelisoa kalafong ea mofets'e, kaha ke litlhare tse thibelang mafura tse lokelang ho sebelisoa ho latela litaelo tse fanoeng ke ngaka le tse hlokang ho fuoa lipetlele kapa litleliniki.