Cobicistat

Litaba

• Pele o nka cobicistat,
• Cobicistat e ka baka litla-morao. Bolella ngaka ea hau haeba letšoao lena le le matla kapa le sa fele:
• Litla-morao tse ling li ka ba mpe. Haeba u e-na le matšoao ana, letsetsa ngaka hang-hang:

Cobicistat e sebelisetsoa ho eketsa palo ea atazanavir (Reyataz, Evotaz) ho batho ba baholo le bana ba boima ba bonyane liponto tse 35 kapa darunavir (Prezista, Prezcobix) ho batho ba baholo le bana ba boima ba bonyane ba liponto tsa 88 (40 kg) ho mali ha meriana ena e sebelisoa ho phekola vaerase ea ho itšireletsa mafung (HIV). Cobicistat e sehlopheng sa meriana e bitsoang cytochrome P450 3A (CYP3A) inhibitors. E sebetsa ka ho eketsa palo ea atazanavir kapa darunavir 'meleng e le hore e ka ba le phello e kholo.

Cobicistat e tla joalo ka letlapa la ho nka ka molomo. Hangata e nkoa ka lijo hang ka letsatsi hammoho le atazanavir kapa darunavir. Nka cobicistat le atazanavir kapa darunavir ka nako e ts'oanang letsatsi le letsatsi. Latela litaelo tsa lengolo la hau la ngaka ka hloko, 'me u kope ngaka kapa setsebi sa metsoako ho u hlalosetsa karolo efe kapa efe eo u sa e utloisiseng. Nka cobicistat hantle feela joalokaha ho laetsoe. Se ke oa e noa hanyane kapa ua e noa khafetsa ho feta kamoo u laetsoeng ke ngaka ea hau.

Ho bohlokoa ho lula u nka cobicistat ka nako e ts'oanang le atazanavir kapa darunavir.

Botsa rakhemisi kapa ngaka ea hau bakeng sa kopi ea tlhaiso-leseling ea moetsi bakeng sa mokuli.

Meriana ena e ka laeloa bakeng sa ts'ebeliso e ngoe; botsa ngaka kapa setsebi sa metsoako bakeng sa tlhaiso-leseling e batsi.

Pele o nka cobicistat,

• bolella ngaka le setsebi sa metsoako haeba u na le alejiki ho cobicistat, meriana efe kapa efe, kapa metsoako efe kapa efe ea matlapa a cobicistat. Botsa rakhemisi oa hau bakeng sa lethathamo la metsoako.
• bolella ngaka ea hau haeba u noa efe kapa efe ea meriana e latelang: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (ha e fumanehe U.S.); colchicine (Colcrys, Mitigare, ho Col-Probenecid); dronedarone (Multaq); meriana ea ergot e kang dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), le methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Temana ea molomo); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, Rifamate, Rifater); sildenafil (ke mofuta oa Revatio feela o sebelisetsoang lefu la matšoafo); simvastatin (Flolipid, Zocor); Wort ea St. John; kapa triazolam (Halcion). Haeba u nka atazanavir hammoho le cobicistat, bolella ngaka hore na u noa drospirenone le ethinyl estradiol (lithibela-pelehi tse ling tsa molomo tse kang Beyaz, Safyral, Yasmin, Yaz, le tse ling); indinavir (Crixivan), irinotecan (Camptosar), kapa nevirapine (Viramune). Ngaka ea hau e kanna ea u joetsa hore u se ke oa nka cobicistat haeba u noa efe kapa efe ea meriana ena.
• bolella ngaka ea hau le setsebi sa meriana hore na ke meriana efe e meng eo u e fuoang kapa eo u rerileng ho e nka. Etsa bonnete ba hore o bua ka tse ling tsa tse latelang: li-anticoagulants ('li-thinner tsa mali') tse kang apixaban (Eliquis), boima ba phofo (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban powder (Xarelto), le warfarin (Coumadin, Jantoven) ; meriana ea antiplatelet e kang clopidogrel (Plavix) le ticagrelor (Brilinta); atorvastatin (Lipitor, ka Caduet); benzodiazepines tse kang diazepam (Valium), estazolam, midazolam e fanoang ka intravenously (ho kena mothapong), le zolpidem (Ambien, Edluar, Intermezzo); beta blockers tse kang carvedilol (Coreg), metoprolol (Lopressor), le timolol; boceprevir (Victrelis) (ha e fumanehe U.S.); bosentan (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine le naloxone (Suboxone, Zubsolv); buspirone; li-block channel tsa calcium tse kang amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, tse ling), felodipine, nifedipine (Adalat, Afeditab, Procardia), le verapamil (Calan, Verelan, others); clarithromycin (Biaxin, ho PrevPac); corticosteroids joalo ka beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonase), le triamcinolone (Nasacort) dasatinib (Sprycel); efavirenz (Sustiva, e Atripla); erythromycin (E.E.S, Erytab, tse ling); etravirine (Tšusumetso); fentanyl (Abstral, Actiq, Fentora, ba bang); itraconazole (Onmel, Sporanox); ketoconazole; meriana ea khatello ea maikutlo e kang amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), le trazodone; meriana ea ho otla ha pelo ka mokhoa o sa tloaelehang joalo ka amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), le quinidine (ho Nuedexta); meriana ea ho oela joalo ka clonazepam (Klonopin), eslicarbazepine (Aptiom), le oxcarbazepine (Trileptal); meriana e hatellang sesole sa 'mele joaloka cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), le tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (e Kaletra); maraviroc (Selzentry); methadone (Dolophine, Methadose); nilotinib (Tasigna); lithibela-pelehi tsa molomo (lipilisi tsa thibelo ea bokhachane); perphenazine; li-inhibitors tse ling tsa phosphodiesterase (PDE5) tse kang avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), le vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, e Kaletra); phofo ea Rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, e Advair); simeprevir (Olysio); telaprevir (Incivek) (ha e fumanehe U.S.); telithromycin (Ketek); tenofovir (Viread, e Atripla, Complera, Truvada, tse ling), thioridazine; tramadol (Conzip, Ultram, ka Ultracet); vinblastine; vincristine (Marqibo Kit); le voriconazole (Vfend). Ngaka ea hau e kanna ea hloka ho fetola litekanyetso tsa meriana ea hau kapa ho u beha leihlo ka hloko bakeng sa litla-morao. Meriana e meng e mengata le eona e ka sebelisana le cobicistat kahoo etsa bonnete ba hore u joetsa ngaka ea hau ka meriana eohle eo u e sebelisang, le tse sa hlahang lenaneng lena.
• haeba o nka cobicistat le atazanavir hape o nka li-antacids (Maalox, Mylanta, Tums, tse ling), li nke lihora tse 2 pele kapa lihora tse 2 kamora cobicistat le atazanavir.
• haeba o noa cobicistat le atazanavir hape o noa moriana oa ho nyekeloa ke lijo, ho nyeheloa ke pelo, kapa liso (H₂ blockers) joalo ka cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), kapa ranitidine (Zantac), li nke ka nako e le 'ngoe kapa bonyane lihora tse 10 kamora ho nka H₂ thibela.
• Haeba o noa cobicistat le atazanavir hape o noa moriana bakeng sa ho nyehlisa, ho nyebella, kapa liso (proton pump inhibitors) joalo ka esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, e Zegerid), pantoprazole (Protonix), kapa rabeprazole (AcipHex) e li nka bonyane lihora tse 12 kamora ho nka proton pump inhibitor.
• bolella ngaka ea hau haeba u kile ua ba le lefu la liphio kapa la sebete.
• bolella ngaka ea hau haeba u imme, rera ho ima, kapa ho anyesa. Haeba u ka ima ha u ntse u nka cobicistat, letsetsa ngaka. Ha ua lokela ho anyesa haeba u tšoaelitsoe ke HIV kapa u noa cobicistat.

Ntle le haeba ngaka ea hau e u joetsa ka tsela e ngoe, tsoela pele ho ja lijo tse tloaelehileng.

Haeba tekanyetso ea hau e latelang e lokela ho hlaha ka lihora tse 12 kapa ho feta, noa lethal dose hang ha u le hopola. Leha ho le joalo, haeba lethal dose le latelang le tla nooa ka nako e ka tlase ho lihora tse 12, tlola lethal dose 'me u tsoele pele ka kemiso ea hau e tloaelehileng ea likhahla Se ke oa nka lethal dose tse peli ho etsetsa e hlolohetsoeng.

Cobicistat e ka baka litla-morao. Bolella ngaka ea hau haeba letšoao lena le le matla kapa le sa fele:

• ho nyekeloa ke pelo

Litla-morao tse ling li ka ba mpe. Haeba u e-na le matšoao ana, letsetsa ngaka hang-hang:

• bosehla ba letlalo kapa mahlo
• lekhopho
• fokotseha ho ntša metsi

Cobicistat e ka baka litla-morao tse ling. Bitsa ngaka ea hau haeba u na le mathata a sa tloaelehang ha u ntse u noa meriana ena.

Haeba o ba le litlamorao tse mpe, uena kapa ngaka ea hau le ka romella tlaleho ho Lenaneo la MedWatch Advers Event Reporting inthaneteng (http://www.fda.gov/Safety/MedWatch) inthaneteng kapa ka mohala ( 1-800-332-1088).

Boloka meriana ena ka setshelong e kene, e koetsoe ka thata, ebile e sa fihlelehe ho bana. E boloke ka mocheso oa kamore le hole le mocheso o feteletseng le mongobo (eseng ka kamoreng ea ho hlapela).

Ho bohlokoa ho boloka litlhare tsohle li sa bonahale le moo bana ba ka fihlelloang lijana tse ngata (joalo ka likelello tsa lipilisi tsa beke le beke le tsa marotholi a mahlo, litlolo, lipache le li-inhalers) ha li thibele bana mme bana ba banyane ba ka li bula habonolo. Ho sireletsa bana ba banyenyane chefo, lula u notlela likepisi tsa polokeho 'me hang-hang beha meriana sebakeng se sireletsehileng - se holimo le hole le moo ba sa se boneng le ho se fihlela. http://www.upandaway.org

Meriana e sa hlokeheng e lokela ho lahloa ka litsela tse ikhethang ho netefatsa hore liphoofolo tse ruuoang lapeng, bana le batho ba bang ba ke ke ba li sebelisa. Leha ho le joalo, ha ua lokela ho tšela meriana ena ka ntloaneng. Sebakeng seo, tsela e molemohali ea ho lahla meriana ea hau ke ka lenaneo la ho khutlisa moriana. Bua le rakhemisi oa hau kapa ikopanye le lefapha la hau la litšila / la ho li sebelisa hape ho ithuta ka mananeo a khutlisetsang sechaba sa heno. Sheba webosaete ea FDA's Disposal of Medicines websaeteng (http://goo.gl/c4Rm4p) bakeng sa tlhaiso-leseling e batsi haeba u sena mokhoa oa ho khutlisa.

Haeba ho na le overdose, letsetsa mohala oa thuso oa taolo ea chefo ho 1-800-222-1222. Tlhahisoleseling e fumaneha inthaneteng ho https://www.poisonhelp.org/help. Haeba motho ea hlokofalitsoeng a oele, a tšoeroe ke sethoathoa, a na le bothata ba ho hema, kapa a sa khone ho tsosoa, hang-hang letsetsa litšebeletso tsa tšohanyetso ho 911.

Boloka linako tsohle le ngaka le laboratori. Ngaka ea hau e tla odara liteko tse itseng tsa laborateng pele le nakong ea kalafo ea hau ho lekola karabelo ea 'mele oa hau ho cobicistat.

Boloka phepelo ea meriana letsohong. Se ke oa emela hore o felloe ke moriana ho tlatsa lengolo la ngaka.

Se ke oa lumella mang kapa mang ho noa meriana ea hau. Botsa rakhemisi oa hau lipotso tseo u nang le tsona mabapi le ho tlatsa lengolo la ngaka.

Ho bohlokoa ho uena hore u boloke lethathamo le ngotsoeng la meriana eo u e nkang u sa e ngolla le eo u sa e ngolisetsang (morekisi) le lihlahisoa tse ling tse kang livithamini, liminerale, kapa litlatsetso tse ling tsa phepo. U lokela ho tla le lenane lena nako le nako ha u etela ngaka kapa ha u amoheloa sepetlele. Hape ke tlhaiso-leseling ea bohlokoa ho tsamaea le uena haeba ho ka hlaha maemo a tšohanyetso.

• Tybost^®

• Evotaz^® (e nang le Atazanavir, Cobicistat)
• Prezcobix^® (e nang le Cobicistat, Darunavir)