Teko ea mali ea ACTH

Teko ea ACTH e lekanya boemo ba lihormone tsa adrenocorticotropic (ACTH) maling. ACTH ke hormone e tsoang lethong la pituitary bokong.

Ho hlokahala sampole ea mali.

Ngaka ea hau e kanna ea u kopa hore tlhahlobo e etsoe hoseng haholo. Sena se bohlokoa, hobane boemo ba cortisol bo fapana letsatsi lohle.

U kanna oa bolelloa hore u tlohele ho noa meriana e ka amang litholoana tsa liteko. Meriana ena e kenyelletsa glucocorticoids e kang prednisone, hydrocortisone, kapa dexamethasone. (Se ke oa emisa meriana ena ntle le ha u laetsoe ke mofani oa hau.)

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba ikutloa feela ho hlaba kapa ho hlaba. Kamora moo, ho kanna ha ba le ho longoa kapa ho longoa hanyenyane. Haufinyane sena sea fela.

Mosebetsi o ka sehloohong oa ACTH ke ho laola glucocorticoid (steroid) hormone cortisol. Cortisol e lokolloa ke tšoelesa ea adrenal. E laola khatello ea mali, tsoekere maling, sesole sa 'mele le karabelo ea khatello ea maikutlo.

Teko ena e ka thusa ho fumana lisosa tsa mathata a itseng a lihormone.

Litekanyetso tse tloaelehileng tsa sampole ea mali e nkuoeng hoseng ke 9 ho isa ho 52 pg / mL (2 ho isa 11 pmol / L).

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li ka leka mefuta e fapaneng. Bua le ngaka ea hau ka se boleloang ke sephetho sa hau sa liteko.

Boemo bo phahameng ho feta bo tloaelehileng ba ACTH bo kanna ba bonts'a:

• Litšoelesa tsa adrenal ha li hlahise cortisol e lekaneng (lefu la Addison)
• Litšoelesa tsa adrenal ha li hlahise lihormone tse lekaneng (congenital adrenal hyperplasia)
• E 'ngoe kapa tse ling tsa litšoelesa tsa endocrine li sebetsa haholo kapa li thehile hlahala (mefuta e mengata ea endocrine neoplasia mofuta oa I)
• Pituitary e etsa ACTH (Cushing disease) e ngata haholo, e atisang ho bakoa ke hlahala e se nang mofets'e ea tšoelesa ea pituitary.
• Mofuta o sa tloaelehang oa hlahala (lung, thyroid, kapa manyeme) o etsang ACTH (ectopic Cushing syndrome) e ngata haholo

Boemo bo tlase ho feta bo tloaelehileng ba ACTH bo ka supa:

• Meriana ea glucocorticoid e hatella tlhahiso ea ACTH (e tloaelehileng haholo)
• Tšoelesa ea pituitary ha e hlahise lihormone tse lekaneng, joalo ka ACTH (hypopituitarism)
• Hlahala ea tšoelesa ea adrenal e hlahisang cortisol e ngata haholo

Ha ho na kotsi e kholo ea ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho nka mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tse amanang le ho huloa mali li nyane empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Li-punctures tse ngata ho fumana methapo
• Hematoma (mali a bokellanang ka tlasa letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Hormone ea serum adrenocorticotropic; Hormone ea Adrenocorticotropic; ACTH e mamelang haholo

• Litšoelesa tsa endocrine

CC ea Chernecky, Berger BJ. Adrenocorticotropic hormone (ACTH, corticotropin) - serum. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 107.

Melmed S, Kleinberg D. Matšoafo a pituitary le lihlahala. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, bahlophisi. Buka ea Williams ea Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 9.

Stewart PM, Newell-Price JDC. Karolo ea adrenal cortex. Ka: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, bahlophisi. Buka ea Williams ea Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 15.