Hemoglobin electrophoresis

Hemoglobin ke protheine e tsamaisang oksijene maling. Hemoglobin electrophoresis e lekanya maemo a mefuta e fapaneng ea protheine ena maling.

Ho hlokahala sampole ea mali.

Ka laborateng, setsebi se beha sampole ea mali pampiring e khethehileng ebe se sebelisa motlakase. Li-hemoglobin li tsamaea pampiring ebe li etsa lihlopha tse bontšang boholo ba mofuta o mong le o mong oa hemoglobin.

Ha ho boitokiso bo khethehileng bo hlokahalang bakeng sa tlhahlobo ena.

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba utloa feela ho hlaba kapa ho hlaba habohloko. Kamora moo, ho ka ba le ho phatloha kapa ho longoa hanyane. Haufinyane sena sea fela.

U ka ba le teko ena haeba mofani oa tlhokomelo ea bophelo a belaela hore u na le bothata bo bakoang ke mefuta e sa tloaelehang ea hemoglobin (hemoglobinopathy).

Mefuta e mengata e fapaneng ea hemoglobin (Hb) e teng. Tse tloaelehileng haholo ke HbA, HbA2, HbE, HbF, HbS, HbC, HbH, le HbM. Batho ba baholo ba phetseng hantle ba na le maemo a bohlokoa a HbA le HbA2 feela.

Batho ba bang le bona ba ka ba le HbF e nyane. Ona ke mofuta o ka sehloohong oa hemoglobin 'meleng oa lesea le e-so hlahe. Mafu a mang a amahanngoa le maemo a phahameng a HbF (ha HbF e feta 2% ea hemoglobin e felletseng).

HbS ke mofuta o sa tloaelehang oa hemoglobin e amanang le anemia ea sickle cell. Ho batho ba nang le boemo bona, lisele tse khubelu tsa mali ka linako tse ling li na le sebopeho sa seoli kapa sekele. Lisele tsena li senyeha habonolo kapa li ka thibela methapo e menyenyane ea mali.

HbC ke mofuta o sa tloaelehang oa hemoglobin e amanang le phokolo ea mali ea hemolytic. Matšoao a teng a bobebe haholo ho feta kamoo a leng kateng ho sickle cell anemia.

Limolek'hule tse ling tse sa tloaelehang tsa Hb li baka mefuta e meng ea phokolo ea mali.

Ho batho ba baholo, tsena ke liperesente tse tloaelehileng tsa limolek'hule tse fapaneng tsa hemoglobin:

• HbA: 95% ho 98% (0.95 ho 0.98)
• HbA2: 2% ho 3% (0.02 ho 0.03)
• HbE: Ha e eo
• HbF: 0.8% ho 2% (0.008 ho 0.02)
• HbS: Ha e eo
• HbC: Ha e eo

Ho masea le bana, tsena ke liperesente tse tloaelehileng tsa limolek'hule tsa HbF:

• HbF (lesea le sa tsoa tsoaloa): 50% ho ea ho 80% (0.5 ho isa ho 0.8)
• HbF (likhoeli tse 6): 8%
• HbF (likhoeli tse fetang 6): 1% ho 2%

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Labs tse ling li sebelisa litekanyo tse fapaneng kapa li kanna tsa leka mehlala e fapaneng. Bua le mofani oa hau ka moelelo oa sephetho sa hau sa liteko.

Maemo a bohlokoa a li-hemoglobin tse sa tloaelehang a ka supa:

• Lefu la Hemoglobin C.
• Hemoglobinopathy e sa tloaelehang
• Phokolo ea mali ea sele
• Boloetse ba mali bo futsitsoeng boo 'mele o etsang mofuta o sa tloaelehang oa hemoglobin (thalassemia)

U kanna oa ba le liphetho tse sa tloaelehang tsa bohata kapa tse sa tloaelehang haeba u bile le tšelo ea mali nakong ea libeke tse 12 tsa tlhahlobo ena.

Ho na le kotsi e nyane haholo e amehang ha ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho nka mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tse amanang le ho huloa mali li nyane empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Hematoma (mali a hahiloeng ka tlas'a letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Hb electrophoresis; Hgb electrophoresis; Electrophoresis - hemoglobin; Thallasemia - motlakase; Sickle cell - electrophoresis; Hemoglobinopathy - electrophoresis

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