Khaello ea Glucose-6-phosphate dehydrogenase

Ho haella ha Glucose-6-phosphate dehydrogenase (G6PD) ke boemo boo lisele tse khubelu tsa mali li senyehang ha 'mele o pepesehetse litlhare tse itseng kapa khatello ea maikutlo ea ts'oaetso. Ke lefa, ho bolelang hore e fetisitsoe malapeng.

Ho haella ha G6PD ho etsahala ha motho a le sieo kapa a se na enzyme e lekaneng e bitsoang glucose-6-phosphate dehydrogenase. Enzyme ena e thusa lisele tse khubelu tsa mali ho sebetsa hantle.

G6PD e nyane haholo e lebisa tšenyehong ea lisele tse khubelu tsa mali. Ts'ebetso ena e bitsoa hemolysis. Ha ts'ebetso ena e etsahala ka mafolofolo, e bitsoa sekhetho sa hemolytic. Likhaolo hangata li khutšoanyane. Lebaka ke hobane 'mele o ntse o tsoela pele ho hlahisa lisele tse khubelu tsa mali, tse nang le ts'ebetso e tloaelehileng.

Ho senngoa ha lisele tse khubelu tsa mali ho ka bakoa ke tšoaetso, lijo tse itseng (joalo ka linaoa tsa fava), le meriana e meng ho kenyelletsa:

• Meriana e loantšang malaria e kang quinine
• Aspirin (tekanyetso e phahameng)
• Lithethefatsi tse seng khahlanong le ho ruruha (li-NSAID)
• Quinidine
• Lithethefatsi tsa Sulfa
• Lithibela-mafu tse kang quinolones, nitrofurantoin
  

Lik'hemik'hale tse ling, joalo ka tse ka har'a mothball, le tsona li ka baka ketsahalo.

United States, khaello ea G6PD e atile haholo har'a batho ba batšo ho feta makhooa. Banna ke bona ba nang le bothata bona ho feta basali.

U na le monyetla oa ho hlaolela boemo bona haeba u:

• Ke African American
• Li hlompheha Bochabela bo Hare, haholo-holo Makurde kapa Sephardic Jewish
• Ke banna
• Ho ba le nalane ea lelapa ea khaello

Mofuta oa bothata bona o atile ho makhooa a lesika la Mediterranean. Mofuta ona o boetse o amahanngoa le likarolo tse bohloko tsa hemolysis. Likarolo li telele ebile li matla ho feta mefuta e meng ea lefu lena.

Batho ba nang le boemo bona ha ba bontše matšoao a lefu lena ho fihlela lisele tsa bona tse khubelu tsa mali li pepesetsoa lik'hemik'hale tse itseng lijong kapa moriana.

Matšoao a atile haholo ho banna mme a kenyeletsa:

• Moroto o lefifi
• Feberu
• Bohloko ka mpeng
• Ho holisa spleen le sebete
• Mokhathala
• Pallor
• Ho otla ha pelo ka potlako
• Phefumoloho e khutšoanyane
• Mmala oa 'mala o mosehla (jaundice)

Ho ka etsoa tlhahlobo ea mali ho lekola boemo ba G6PD.

Liteko tse ling tse ka etsoang li kenyelletsa:

• Boemo ba Bilirubin
• Palo e felletseng ea mali
• Hemoglobin - moroto
• Boemo ba Haptoglobin
• Teko ea LDH
• Teko ea phokotso ea Methemoglobin
• Palo ea Reticulocyte

Kalafo e ka kenyelletsa:

• Meriana ea ho phekola tšoaetso, haeba e le teng
• Ho emisa lithethefatsi life kapa life tse bakang tšenyo ea lisele tse khubelu tsa mali
• Litšelo, maemong a mang

Maemong a mangata, liketsahalo tsa hemolytic lia iphelela.

Maemong a sa tloaelehang, ho hloleha ha liphio kapa lefu le ka hlaha kamora ketsahalo e matla ea haemolytic.

Bitsa mofani oa hao oa tlhokomelo ea bophelo haeba u e-na le matšoao a boemo bona.

Bitsa mofani oa hau haeba u fumanoe u na le khaello ea G6PD mme matšoao a eona ha a nyamele kamora kalafo.

Batho ba nang le khaello ea G6PD ba tlameha ho qoba ka tieo lintho tse ka bakang ketsahalo. Bua le mofani oa hau ka meriana ea hau.

Tlhabollo ea 'mele kapa liteko li ka fumaneha ho ba nang le nalane ea lelapa ea boemo boo.

Khaello ea G6PD; Hemolytic anemia ka lebaka la khaello ea G6PD; Anemia - hemolytic ka lebaka la khaello ea G6PD

• Lisele tsa mali

Gregg XT, Prchal JT. Li-enzyme tsa lisele tse khubelu tsa mali. Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 44.

Lissauer T, mathata a Carroll W. Haematological. Ka: Lissauer T, Carroll W, bahlophisi. Illustrated Textbook of Paediatrics. La 5th. Philadelphia, PA: Elsevier; 2018: khaolo ea 23.

Michel M. Autoimmune le li-intravascular hemolytic anemias. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 151.