Gene ea JAK2 ke Eng?

Litaba

• Kakaretso
• Liphatsa tsa lefutso le bokuli
• Mosebetsi o tloaelehileng oa JAK2
• JAK2 le mafu a mali
• Phuputso ea JAK2

Kakaretso

Enzyme ea JAK2 esale e le sepheo sa lipatlisiso haufinyane bakeng sa kalafo ea myelofibrosis (MF). E 'ngoe ea kalafo ea morao-rao le e ts'episang haholo bakeng sa MF ke setlhare se emisang kapa se liehisa hore na enzyme ea JAK2 e sebetsa hakae. Sena se thusa ho fokotsa lefu lena.

Tsoela pele ho bala ho ithuta ka enzyme ea JAK2, le hore na e amana joang le lefutso la JAK2.

Liphatsa tsa lefutso le bokuli

Ho utloisisa hantle liphatsa tsa lefutso tsa JAK2 le enzyme, hoa thusa ho ba le kutloisiso ea mantlha ea hore na liphatsa tsa lefutso le li-enzyme li sebetsa joang 'meleng ea rona.

Liphatsa tsa lefutso ke litaelo kapa lipolane tsa 'mele ea rona hore li sebetse. Re na le sete ea litaelo tsena kahare ho sele e ngoe le e ngoe ea 'mele ea rona. Li bolella lisele tsa rona mokhoa oa ho etsa liprotheine, tse tsoelang pele ho etsa li-enzyme.

Li-enzyme le liprotheine li fetisetsa melaetsa likarolong tse ling tsa 'mele ho etsa mesebetsi e meng, joalo ka ho thusa ka tšilo ea lijo, ho khothaletsa kholo ea lisele kapa ho sireletsa' mele ea rona ho tšoaetsong.

Ha lisele tsa rona li ntse li hola le ho ikarola, liphatsa tsa lefutso tse ka har'a lisele li ka fetoha. Sele e fetisetsa phetoho eo seleng e 'ngoe le e' ngoe eo e e etsang. Ha liphatsa tsa lefutso li fetoha, ho ka etsa hore lipolane li be thata ho li bala.

Ka linako tse ling, phetoho e baka phoso e sa baleheng hoo sele e ke keng ea etsa protheine efe kapa efe. Ka linako tse ling, phetoho e etsa hore protheine e sebetse nako e fetang kapa e lule e butsoe khafetsa. Ha phetoho e sitisa tšebetso ea protheine le enzyme, e ka baka mafu 'meleng.

Mosebetsi o tloaelehileng oa JAK2

Mofuta oa JAK2 o fa lisele tsa rona litaelo tsa ho etsa protheine ea JAK2, e khothalletsang kholo ea lisele. Mofuta oa JAK2 le enzyme li bohlokoa haholo bakeng sa ho laola kholo le tlhahiso ea lisele.

Li bohlokoa haholo bakeng sa kholo le tlhahiso ea lisele tsa mali. Enzyme ea JAK2 e sebetsa ka thata liseleng tsa bakoang mongoaneng oa rona oa masapo. E tsejoa hape e le lisele tsa methapo ea mali, lisele tsena li ikarabella ho theha lisele tse ncha tsa mali.

JAK2 le mafu a mali

Liphetoho tse fumanoang ho batho ba nang le MF li etsa hore enzyme ea JAK2 e lule e butsoe kamehla. Sena se bolela hore enzyme ea JAK2 e lula e sebetsa, e lebisang ho tlhahiso e fetelletseng ea lisele tse bitsoang megakaryocyte.

Megakaryocyte ena e bolella lisele tse ling ho lokolla collagen. Ka lebaka leo, lisele tse bohale li qala ho bopa mokong oa masapo - lets'oao la MF.

Liphetoho ho JAK2 le tsona li hokahane le mathata a mang a mali. Hangata, liphetoho li hokahana le boemo bo bitsoang polycythemia vera (PV). Ho PV, phetoho ea JAK2 e baka tlhahiso e sa laoleheng ea lisele tsa mali.

Hoo e ka bang liperesente tse 10 ho isa ho tse 15 tsa batho ba nang le PV ba tla tsoelapele ho nts'etsapele MF. Bafuputsi ha ba tsebe hore na ke eng e bakang batho ba bang ba nang le liphetoho tsa JAK2 ho nts'etsapele MF ha ba bang ba hlahisa PV ho fapana.

Phuputso ea JAK2

Hobane liphetoho tsa JAK2 li fumanoe ho batho ba fetang halofo ea batho ba nang le MF, mme batho ba fetang liperesente tse 90 ba nang le PV, e bile taba ea merero e mengata ea lipatlisiso.

Ho na le sethethefatsi se le seng feela se amoheloang ke FDA, se bitsoang ruxolitinib (Jakafi), se sebetsang le li-enzyme tsa JAK2. Meriana ena e sebetsa joalo ka JAK inhibitor, ho bolelang hore e fokotsa ts'ebetso ea JAK2.

Ha tšebetso ea enzyme e fokotseha, enzyme ha e buloe kamehla. Sena se lebisa ho tlhahiso e nyane ea megakaryocyte le collagen, mme qetellong e liehisa leqhubu la lisele tsa lebali ho MF.

Ruxolitinib ea lithethefatsi e boetse e laola tlhahiso ea lisele tsa mali. E etsa sena ka ho fokotsa ts'ebetso ea JAK2 liseleng tsa methapo ea mali. Sena se e thusa ho PV le MF ka bobeli.

Hajoale, ho na le liteko tse ngata tsa bongaka tse shebaneng le li-inhibitors tse ling tsa JAK.Bafuputsi ba ntse ba sebetsana le mokhoa oa ho sebelisa liphatsa tsa lefutso le enzyme ka ts'epo ea hore ba tla fumana kalafo kapa pheko e betere ea MF.