Teko ea liphatsa tsa lefutso tsa TP53

Litaba

• Teko ea liphatsa tsa lefutso ea TP53 ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea TP53?
• Ho etsahalang nakong ea teko ea liphatsa tsa lefutso tsa TP53?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea TP53?
• Litšupiso

Teko ea liphatsa tsa lefutso ea TP53 ke eng?

Teko ea liphatsa tsa lefutso ea TP53 e batla phetoho, e tsejoang e le phetoho, liphatseng tse bitsoang TP53 (tumor protein 53). Liphatsa tsa lefutso ke likarolo tsa mantlha tsa lefutso tse fetisitsoeng ho tsoa ho mme le ntate oa hau.

TP53 ke lefutso le thusang ho emisa kholo ea lihlahala. E tsejoa e le khatello ea hlahala. Lefu la khatello ea hlahala le sebetsa joalo ka mariki koloing. E beha "mariki" liseleng, kahoo ha li arohane kapele haholo. Haeba u na le phetoho ea TP53, lefutso le ka se khone ho laola kholo ea lisele tsa hau. Ho hola ha sele ho sa laoleheng ho ka lebisa ho mofets'e.

Phetoho ea TP53 e ka futsetsoa ho batsoali ba hau, kapa ea fumanoa hamorao bophelong ho tsoa tikolohong kapa phosong e etsahalang 'meleng oa hau nakong ea karohano ea sele.

• Phetoho ea lefa la TP53 e tsejoa e le lefu la Li-Fraumeni.
• Li-Fraumeni syndrome ke boemo bo sa tloaelehang ba liphatsa tsa lefutso bo ka eketsang kotsi ea mefuta e meng ea mofetše.
• Kankere ena e kenyelletsa mofetše oa matsoele, mofetše oa masapo, kankere ea mali le kankere ea linama tse bonolo, eo hape e bitsoang sarcomas

Liphetoho tsa TP53 tse fumanehang (tse tsejoang hape e le somatic) li atile haholo. Liphetoho tsena li fumanoe hoo e ka bang halofo ea linyeoe tsohle tsa mofetše, le mefuta e fapaneng ea mofets'e.

Mabitso a mang: Tlhatlhobo ea phetoho ea TP53, TP53 tlhahlobo e felletseng ea liphatsa tsa lefutso, TP53 somatic mutation

E sebelisetsoa eng?

Teko e sebelisetsoa ho batla phetoho ea TP53. Ha se teko e tloaelehileng.Hangata e fuoa batho ho latela nalane ea lelapa, matšoao, kapa tlhahlobo ea mofetše e fetileng.

Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea TP53?

U kanna oa hloka tlhahlobo ea TP53 haeba:

• U fumanoe u e-na le kankere ea masapo kapa e bonolo ea mesifa pele u le lilemo li 45
• U fumanoe u e-na le kankere ea matsoele ea pele ho nako ea ho ilela khoeli, hlahala bokong, kankere ea mali, kapa mofetše oa matšoafo pele ho lilemo tse 46.
• U bile le hlahala e le 'ngoe kapa ho feta pele ho lilemo tse 46
• Motho a le mong kapa ba bangata ba lelapa la hau ba fumanoe ba na le lefu la Li-Fraumeni le / kapa ba bile le mofets'e pele ba le lilemo li 45

Tsena ke matšoao a hore o ka ba le phetoho e futsitsoeng ea lefutso la TP53.

Haeba u fumanoe u na le mofetše mme u se na nalane ea lelapa ka lefu lena, mofani oa tlhokomelo ea bophelo a ka laela tlhahlobo ena ho bona hore na phetoho ea TP53 e kanna ea baka mofetše oa hau. Ho tseba hore na o na le phetoho ho ka thusa mofani oa hau ho rera kalafo le ho bolela esale pele litlamorao tsa lefu la hau.

Ho etsahalang nakong ea teko ea liphatsa tsa lefutso tsa TP53?

Teko ea TP53 hangata e etsoa maling kapa mokong oa masapo.

Haeba o etsa tlhahlobo ea mali, setsebi sa tlhokomelo ea bophelo se tla nka sampole ea mali mothapong o letsohong la hao, a sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Haeba u ntse u etsa tlhahlobo ea moko oa masapo, Tsamaiso ea hau e ka kenyelletsa mehato e latelang:

• U tla robala ka lehlakore kapa ka mpeng, ho latela hore na ke lesapo lefe le tla sebelisoa ho etsa liteko. Boholo ba liteko tsa moko oa masapo li nkuoa masapong a noka.
• 'Mele oa hau o tla koaheloa ka lesela, hoo ho bonts'ang feela sebaka se haufi le sebaka sa liteko.
• Sebaka sena se tla hloekisoa ka sethibela-mafu.
• U tla fumana ente ea tharollo ea bohlasoa. E ka hlaba.
• Hang ha sebaka se felloa ke matla, mofani oa tlhokomelo ea bophelo o tla nka sampole. U tla hloka ho bua leshano u khutsitse nakong ea liteko.
• Mofani oa tlhokomelo ea bophelo o tla sebelisa sesebelisoa se ikhethileng se kenang masapong ho ntša sampole ea lisele tsa moko oa masapo. U kanna oa utloa khatello sebakeng seo ha sampole e ntse e nkuoa.
• Kamora 'tlhahlobo, mofani oa tlhokomelo ea bophelo o tla koahela sebaka sena ka bandage.
• Rera hore motho e mong au khannele hae, hobane u ka fuoa setulo sa botona pele ho liteko, se ka etsang hore u otsele.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Hangata ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea mali kapa ea mokoallo oa masapo.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Kamora tlhahlobo ea moko oa masapo, o kanna oa ikutloa o le manganga kapa o le bohloko setsing sa ente. Hangata sena sea fela ka matsatsi a 'maloa. Mofani oa hao oa tlhokomelo ea bophelo a ka khothaletsa kapa a fana ka moriana oa bohloko oa ho thusa.

Liphetho li bolelang?

Haeba u fumanoe u na le lefu la Li-Fraumeni, ho joalo ha e etse joalo ho bolela hore o na le mofetše, empa kotsi ea hau e phahame ho feta batho ba bangata. Empa haeba o na le phetoho, o ka nka mehato ea ho fokotsa likotsi, joalo ka:

• Ho hlahlojoa hangata ha mofets'e. Kankere e ka phekoleha ha e fumanoa mekhahlelong ea pele.
• Ho etsa liphetoho bophelong, joalo ka ho ikoetlisa haholoanyane le ho ja lijo tse phetseng hantle
• Chemoprevention, ho noa meriana e itseng, livithamini kapa lintho tse ling ho fokotsa kotsi kapa ho liehisa kholo ea mofets'e.
• Ho tlosa lisele tse "kotsing"

Mehato ena e tla fapana ho latela nalane ea bophelo ba hau le semelo sa lelapa.

Haeba u na le mofetše mme liphetho tsa hau li bontša phetoho e fumanoeng ea TP53 (phetoho e fumanoe, empa ha u na nalane ea lelapa ea mofets'e kapa lefu la Li-Fraumeni), mofani oa hau a ka sebelisa tlhahisoleseling ho thusa ho bolela esale pele hore na lefu la hau le tla hlaha joang kalafo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea TP53?

Haeba u fumanoe u na le kapa u belaella hore u na le lefu la Li-Fraumeni, ho ka thusa ho bua le moeletsi oa liphatsa tsa lefutso. Moeletsi oa liphatsa tsa lefutso ke setsebi se koetlisitsoeng ka ho khetheha liphatseng tsa lefutso le liteko tsa lefutso. Haeba ha u e-so hlahlojoe, moeletsi a ka u thusa ho utloisisa likotsi le melemo ea tlhahlobo. Haeba o lekile, moeletsi a ka u thusa ho utloisisa litholoana le ho u tataisetsa ts'ehetsong ea lits'ebeletso le lisebelisoa tse ling.

Litšupiso

1. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Liphatsa tsa lefutso tsa onncogene le hlahala e hatellang; [e ntlafalitsoeng 2014 Jun 25; e qotsitsoeng 2018 Jun 29]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/cancer-causes/genetics/genes-and-cancer/oncogenes-tumor-suppressor-genes.html
2. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2020. Mekhoa ea kalafo e reretsoeng e sebelisoa joang ho phekola mofets'e; [e ntlafalitsoeng 2019 Dec 27; e qotsitsoeng 2020 ka la 13 Mots'eanong]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
3. Cancer.net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Li-Fraumeni Syndrome; 2017 Oct [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.net/cancer-types/li-fraumeni-syndrome
4. Cancer.net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005--2020. Ho utloisisa kalafo e lebisitsoeng; 2019 Pherekhong 20 [e qotsitsoeng ka 2020 Mots'eanong 13]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/understanding-targeted-therapy
5. Litsi tsa Tlhokomelo le Thibelo ea Maloetse [Internet]. Atlanta: Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Thibelo le Taolo ea Kankere: Liteko tsa Tlhatlhobo; [e ntlafalitsoeng 2018 Mots'eanong oa 2; e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cdc.gov/cancer/dcpc/prevention/screening.htm
6. Li-Fraumeni Syndrome: Mokhatlo oa LFSA [Inthanete]. Holliston (MA): Mokhatlo oa Li-Fraumeni Syndrome; c2018. LFS ke eng?: Mokhatlo oa Li-Fraumeni Syndrome; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.lfsassociation.org/what-is-lfs
7. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. Tlhahiso ea moko oa masapo le litabatabelo: Kakaretso; 2018 Jan 12 [e qotsitsoeng 2018 Jun 29]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2018. Boitsebiso ba teko: P53CA: Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequicing Exons 4-9: Clinical and Interpretive; [e qotsitsoeng 2018 Jun 29]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62402
9. Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2018. Boitsebiso ba teko: TP53Z: Gene ea TP53, Tlhahlobo e Felletseng ea Gene: Kliniki le Tlhaloso; [e qotsitsoeng 2018 Jun 29]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/35523
10. Setsi sa Kankere sa MD Anderson [Marang-rang]. Setsi sa Univesithi ea Texas MD Anderson Cancer; c2018. Tlhahlobo ea TP53; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mdanderson.org/research/research-resource/core-facilities/molecular-diagnostics-lab/services/tp53-mutation-analysis.html
11. Phetolelo ea Merck Manual Consumer [Inthanete]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Tlhahlobo ea Bone Marrow; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
12. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: chemoprevention; [e qotsitsoeng ka 2018 Phupu 11]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=chemoprevention
13. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Teko ea liphatsa tsa lefutso bakeng sa li-syndromes tsa mofetše oa lefutso; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet
14. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukantswe ya NCI ya Dipehelo tsa Kankere: gene; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
15. NeoGenomics [Inthanete]. Fort Myers (FL): NeoGenomics Laboratories; c2018. Tlhahlobo ea TP53; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://neogenomics.com/test-menu/tp53-mutation-analysis
16. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. TP53 liphatsa tsa lefutso; 2018 Jun 26 [e qotsitsoeng ka 2018 Phuptjane 29]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/gene/TP53
17. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Phetoho ea lefutso ke eng mme liphetoho li etsahala joang ?; 2018 Jun 26 [e qotsitsoeng ka 2018 Phuptjane 29]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/primer/mutationsanddisorders/genemutation
18. Parrales A, Iwakuma T. Ho shebella Oncogenic Mutant p53 bakeng sa Phekolo ea Kankere. Ka pele Oncol [Inthanete]. 2015 Dec 21 [e qotsitsoeng ka 2020 Mots'eanong 13]; 5: 288. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685147
19. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2018. Health Encyclopedia: Kankere ea matsoele: Liteko tsa liphatsa tsa lefutso; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=34&contentid=16421-1
20. Quest Diagnostics [Inthanete]. Diagnostics ea Quest; c2000–2017. Setsi sa Teko: TP53 Somatic Mutation, Prognostic; [e qotsitsoeng 2018 Jun 29]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=16515
21. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2017. Tlhahisoleseling ea Bophelo: Bone Marrow Aspiration le Biopsy: Kamoo E Etsoang Kateng; [e ntlafalitsoeng ka la 3 Mots'eanong 3; e qotsitsoeng 2018 Jul 17]; [li-skrini tse ka bang 5]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/biopsy-bone-marrow/hw200221.html#hw200245

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.