Tlhokomelo ea Lithethefatsi

Litaba

• Tlhokomelo ea lithethefatsi ea kalafo (TDM) ke eng?
• E sebelisetsoa eng?
• Hobaneng ke hloka TDM?
• Ho etsahalang nakong ea TDM?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi ho TDM?
• Liphetho li bolelang?
• Litšupiso

Tlhokomelo ea lithethefatsi ea kalafo (TDM) ke eng?

Tlhokomelo ea lithethefatsi ea kalafo (TDM) e etsa liteko tse lekanyang boholo ba meriana e itseng maling a hau. E etsoa ho netefatsa hore palo ea meriana eo u e sebelisang e bolokehile ebile e sebetsa.

Bongata ba meriana e ka nooa ka nepo ntle le liteko tse khethehileng. Empa bakeng sa mefuta e meng ea meriana, ho ka ba thata ho fumana tekanyetso e fanang ka moriana o lekaneng ho phekola boemo ba hau ntle le ho baka litla-morao tse kotsi. TDM e thusa mofani oa hau ho tseba hore na o noa moriana o nepahetseng oa meriana ea hau.

Mabitso a mang: litekanyetso tsa meriana ea tlhahlobo ea mali, kalafo ea lithethefatsi

E sebelisetsoa eng?

Tlhokomelo ea lithethefatsi ea kalafo (TDM) e sebelisetsoa ho fumana litekanyetso tse ntle bakeng sa batho ba noang mefuta e itseng ea meriana e thata. Ka tlase ke meriana e tloaelehileng haholo e lokelang ho beoa leihlo.

Hobaneng ke hloka TDM?

U kanna oa hloka tlhahlobo ha u qala ho noa moriana. Sena se thusa mofani oa hau ho fumana tekanyo e sebetsang ka ho fetisisa ho uena. Hang ha tekanyetso eo e lekantsoe, o ka lekoa khafetsa ho netefatsa hore moriana o ntse o sebetsa ntle le ho ba kotsi. U kanna ua hloka ho hlahlojoa haeba u na le matšoao a litlamorao tse mpe. Litla-morao lia fapana ho latela meriana. Mofani oa hao oa tlhokomelo ea bophelo o tla u tsebisa hore na ke matšoao afe ao u lokelang ho a ela hloko.

Ho etsahalang nakong ea TDM?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ho ipapisitse le mofuta oa moriana oo u o sebelisang, o kanna oa hloka ho hlophisa tlhahlobo ea hau pele kapa kamora ho noa lethal dose.

Na ho na le likotsi ho TDM?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Liphetho tsa hau li tla bonts'a haeba maemo a meriana maling a hau a le molemong o thusang lingaka empa o se kotsi. Sena se bitsoa mofuta oa kalafo. Mefuta e fapana ho latela mofuta oa meriana le litlhoko tsa hau tsa bophelo bo botle. Haeba sephetho sa hau se le sieo, mofani oa hau a ka hloka ho lokisa litekanyetso tsa hau. Haeba litekanyetso tsa hau li fetotsoe, o ka fumana liteko tse pheta-phetoang ho fihlela litekanyetso tsa hau tsa meriana li oela mefuteng ea kalafo.

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Litšupiso

1. DoveMed [Inthanete]. LeebaMed; c2019. Phekolo ea Ts'ebeliso ea Lithethefatsi; 2014 Mar 8 [e ntlafalitsoeng 2018 ka la 25; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.dovemed.com/common-procedures/procedures-laboratory/therapeutic-drug-monitoring-tdm
2. Kang JS, Lee MH. Kakaretso ea tlhokomelo ea lithethefatsi ea kalafo. Sekorea J Intern Med. [Inthanete]. 2009 Mar [e qotsitsoeng ka 2020 Mar 27]; 24 (1): 1-10. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687654
3. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001--2020. Phekolo ea Ts'ebeliso ea Lithethefatsi; [e ntlafalitsoeng 2018 Dec 16; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/therapeutic-drug-monitoring
4. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
5. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2020. Methati ea kalafo ea kalafo: Kakaretso; [e ntlafalitsoeng ka 2020 Mar 27; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/therapeutic-drug-levels
6. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2020. Tlhahisoleseling ea Bophelo: Litekanyetso tsa Bongaka Madi: Liphetho; [e ntlafalitsoeng 2019 Dec 8; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 8]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/medicine-levels-in-blood/abq4055.html#abq4062
7. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2020. Tlhahisoleseling ea Bophelo: Litekanyetso tsa Bongaka Maling: Kakaretso ea Teko; [e ntlafalitsoeng 2019 Dec 8; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/medicine-levels-in-blood/abq4055.html#abq4056
8. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2020. Tlhahisoleseling ea Bophelo: Litekanyo tsa Bongaka Maling: Hobaneng ha li etsoa; [e ntlafalitsoeng 2019 Dec 8; e qotsitsoeng ka 2020 Mar 27]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/medicaltest/medicine-levels-in-blood/abq4055.html#abq4057

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.