Phenylalanine: Melemo, Litlamorao le Mehloli ea Lijo

Litaba

• Phenylalanine ke eng?
• Ke ea Bohlokoa Bakeng sa Ts'ebetso e Tloaelehileng ea 'Mele oa Hau
• E kanna ea ba Molemo Bakeng sa Maemo a Mang a Bongaka
• Litla-morao
• Lijo tse Phahameng Phenylalanine
• Ntlha ea Bohlokoa

Phenylalanine ke amino acid e fumanoang lijong tse ngata mme e sebelisoa ke 'mele oa hau ho hlahisa liprotheine le limolek'hule tse ling tsa bohlokoa.

E ithutiloe ka litlamorao tsa eona ho khatello ea maikutlo, bohloko le mathata a letlalo.

Sengoliloeng sena se u joetsa tsohle tseo u hlokang ho li tseba ka phenylalanine, ho kenyelletsa melemo ea eona, litla-morao le mehloli ea lijo.

Phenylalanine ke eng?

Phenylalanine ke amino acid, e leng tsona tse hahang liprotheine 'meleng oa hau.

Molek'hule ena e teng ka mefuta e 'meli kapa litokisetso: L-phenylalanine le D-phenylalanine. Li batla li tšoana empa li na le sebopeho sa limolek'hule se fapaneng hanyane ().

Foromo ea L e fumanoa lijong 'me e sebelisetsoa ho hlahisa liprotheine' meleng oa hau, ha mofuta oa D o ka etsoa bakeng sa ts'ebeliso ea lits'ebetso tse ling tsa bongaka (2, 3).

'Mele oa hau o sitoa ho hlahisa L-phenylalanine e lekaneng ka bo oona, ka hona e nkuoa e le amino acid ea bohlokoa e lokelang ho fumanoa ka lijo tsa hau (4).

E fumanoa mefuteng e fapaneng ea lijo - ka bobeli mehloli ea limela le liphoofolo ().

Ntle le karolo ea eona tlhahisong ea liprotheine, phenylalanine e sebelisetsoa ho etsa limolek'hule tse ling tsa bohlokoa 'meleng oa hau, tseo tse' maloa tsa tsona li romellang lipontšo lipakeng tsa likarolo tse fapaneng tsa 'mele oa hau ().

Phenylalanine e ithutiloe e le kalafo bakeng sa maemo a mangata a bongaka, ho kenyeletsoa mathata a letlalo, khatello ea maikutlo le bohloko (3).

Leha ho le joalo, ho ka ba kotsi ho batho ba nang le lefu la liphatsa tsa lefutso phenylketonuria (PKU) (7).

Phenylalanine ke amino acid ea bohlokoa e sebelisetsoang ho hlahisa liprotheine le ho saena limolek'hule. E ithutile e le kalafo bakeng sa maemo a mangata a bongaka empa e kotsi ho ba nang le bothata bo itseng ba lefutso.

Ke ea Bohlokoa Bakeng sa Ts'ebetso e Tloaelehileng ea 'Mele oa Hau

'Mele oa hau o hloka phenylalanine le li-amino acid tse ling ho etsa liprotheine.

Liprotheine tse ngata tsa bohlokoa li fumanoa bokong ba hao, mali, mesifa, litho tsa ka hare le hoo e ka bang kae kapa kae 'meleng oa hau.

Ho feta moo, phenylalanine e bohlokoa molemong oa tlhahiso ea limolek'hule tse ling, ho kenyelletsa (3):

• Tyrosine: Amino acid ena e hlahisoa ka kotloloho ho tsoa ho phenylalanine. E ka sebelisoa ho etsa liprotheine tse ncha kapa ho fetoloa limolek'hule tse ling lenaneng lena (,).
• Epinephrine le norepinephrine: Ha u thulana le khatello ea maikutlo, limolek'hule tsena li bohlokoa molemong oa karabelo ea "ntoa kapa sefofane" ea 'mele oa hau.
• Dopamine: Molek'hule ena e ameha maikutlong a thabo bokong ba hau, hape le ho etsa mehopolo le boiphihlelo ba ho ithuta ().

Mathata a mesebetsi e tloaelehileng ea limolek'hule tsena a ka baka litlamorao tse mpe tsa bophelo bo botle (,).

Kaha phenylalanine e sebelisetsoa ho etsa limolek'hule tsena 'meleng oa hau, e ithutiloe e le kalafo e ka bang teng maemong a itseng, ho kenyeletsoa le khatello ea maikutlo ().

Phenylalanine e ka fetoloa ho amino acid tyrosine, e ntan'o sebelisoa ho hlahisa limolek'hule tsa bohlokoa tse bontšang. Limolek'hule tsena lia ameha likarolong tsa tšebetso e tloaelehileng ea 'mele oa hau, ho kenyelletsa maikutlo a hau le khatello ea maikutlo.

E kanna ea ba Molemo Bakeng sa Maemo a Mang a Bongaka

Liphuputso tse 'maloa li hlahlobile hore na phenylalanine e ka ba molemo ho phekola maemo a itseng a bongaka.

Phuputso e 'ngoe e bontšitse hore e ka sebetsa hantle ho phekoleng vitiligo, lefu la letlalo le bakang tahlehelo ea' mala oa letlalo le blotching ().

Liphuputso tse ling li tlalehile hore ho eketsa lisebelisoa tsa phenylalanine ho pepeseha ha leseli la UV ho ka ntlafatsa mmala oa letlalo ho batho ba nang le boemo bona (,).

Phenylalanine e ka sebelisoa ho hlahisa molek'hule ea dopamine. Ho se sebetse hantle ha dopamine bokong ho amahanngoa le mefuta e meng ea khatello ea maikutlo (,).

Phuputso e le 'ngoe e nyane ea batho ba 12 e bontšitse molemo o ka bang teng oa motsoako oa D- le L-mefuta ea amino acid ena bakeng sa ho phekola khatello ea maikutlo, ka 2/3 ea bakuli e bonts'ang ntlafatso ().

Leha ho le joalo, ho na le ts'ehetso e 'ngoe e fokolang bakeng sa litlamorao tsa phenylalanine ho khatello ea maikutlo, mme lithuto tse ngata ha li so fumane melemo e hlakileng (,,).

Ntle le vitiligo le khatello ea maikutlo, phenylalanine e ithutiloe bakeng sa litlamorao tse ka bang teng ho:

• Bohloko: Mofuta oa D oa phenylalanine o ka kenya letsoho ho kokobetsa bohloko maemong a mang, leha liphetho tsa boithuto li tsoakane (2,,,).
• Ho tlohela joala: Phuputso e nyane e bonts'a hore amino acid ena, hammoho le li-amino acid tse ling, li ka thusa ho fokotsa matšoao a ho tlohela joala ().
• Lefu la Parkinson: Bopaki bo fokolang haholo bo fana ka maikutlo a hore phenylalanine e ka ba molemo ho phekoleng lefu la Parkinson, empa lithuto tse ling lia hlokahala ().
• ADHD: Hajoale, lipatlisiso ha li bontše melemo ea amino acid ena bakeng sa kalafo ea khaello ea khatello ea maikutlo (ADHD) (,).

Phenylalanine e ka ba molemo ho phekoleng lefu la letlalo vitiligo. Bopaki ha bo fane ka ts'ehetso e matla bakeng sa katleho ea amino acid ena ho phekoleng maemo a mang, leha ho entsoe lipatlisiso tse fokolang tsa boleng bo holimo.

Litla-morao

Phenylalanine e fumanoa lijong tse ngata tse nang le protheine mme "ka kakaretso e tsejoa e bolokehile" ke Tsamaiso ea Lijo le Lithethefatsi (FDA) (27).

Palo ea amino acid ena e fumanoang lijong ha ea lokela ho beha kotsi ho batho ba bang ba phetseng hantle.

Ho feta moo, litla-morao tse fokolang kapa tse se nang letho hangata li bonoa litekong tsa tlatsetso tsa 23-45 mg ka ponto (50-100 mg ka kg) ea boima ba 'mele (,).

Leha ho le joalo, ho ka ba molemo bakeng sa bakhachane ho qoba ho noa phenylalanine.

Ntle le moo, ho na le mokhelo o hlokomelehang khafetsa polokelong ea amino acid ena.

Batho ba nang le amino acid metabolism metabolism phenylketonuria (PKU) ha ba khone ho sebetsana le phenylalanine hantle. Ba kanna ba ba le pherekano ea phenylalanine maling a bona ka makhetlo a ka bang 400 ho feta a se nang PKU (3, 7).

Ts'ebetso ena e phahameng e kotsi e ka baka tšenyo ea boko le bokooa ba kelello, hammoho le mathata a ho tsamaisa li-amino acid tse ling ho ea bokong (7,).

Ka lebaka la ho teba ha bothata bona, masea ka kakaretso a hlahlobeloa PKU hang kamora ho hlaha.

Batho ba nang le PKU ba beoa lijong tse ikhethileng tse nang le protheine e tlase, eo hangata e bolokiloeng bophelo bohle (7).

Phenylalanine e nkuoa e bolokehile ka bongata bo fumanoang lijong tse tloaelehileng. Leha ho le joalo, batho ba nang le bothata ba phenylketonuria (PKU) ba sitoa ho silafatsa amino acid ena mme ba tlameha ho fokotsa ts'ebeliso ka lebaka la litlamorao tse mpe tsa bophelo bo botle.

Lijo tse Phahameng Phenylalanine

Lijo tse ngata li na le phenylalanine, ho kenyeletsoa lihlahisoa tsa limela le tsa liphoofolo.

Lihlahisoa tsa soya ke e meng ea mehloli e metle ea limela tsa amino acid, hammoho le lipeo le linate tse ling, ho kenyeletsoa linaoa tsa soya, peo ea mokopu le lipeo tsa squash ().

Soy protein supplements e ka fana ka ligrama tse 2,5 tsa phenylalanine ho li-calorie tse 200 tse sebeletsang (, 29).

Bakeng sa lihlahisoa tsa liphoofolo, mahe, lijo tsa leoatleng le nama e itseng ke mehloli e metle, e fanang ka ligrama tse 2-3 ka khalori e 200 e sebeletsang (, 29).

Ka kakaretso, mohlomong ha u hloke ho khetha ka ho khetheha lijo tse ipapisitseng le lintlha tse phahameng tsa phenylalanine.

Ho ja mefuta e fapaneng ea lijo tse nang le protheine letsatsi lohle ho tla u fa phenylalanine eohle eo u e hlokang, hammoho le li-amino acid tse ling tsa bohlokoa.

Lijo tse ngata, ho kenyeletsoa lihlahisoa tsa soya, mahe, lijo tsa leoatleng le nama, li na le phenylalanine. Ho ja mefuta e fapaneng ea lijo tse nang le protheine letsatsi lohle ho tla u fa li-amino acid tsohle tseo 'mele oa hau o li hlokang, ho kenyelletsa phenylalanine.

Ntlha ea Bohlokoa

Phenylalanine ke amino acid ea bohlokoa e fumanoang lijong tsa limela le tsa liphoofolo.

E kanna ea ba le melemo bakeng sa vitiligo ea lefu la letlalo, empa lipatlisiso ka litlamorao tsa eona ho khatello ea maikutlo, bohloko kapa maemo a mang li na le moeli.

Ka kakaretso e nkoa e sireletsehile, empa batho ba nang le phenylketonuria (PKU) ba ka ba le litla-morao tse kotsi.