Na Psoriasis ke Mafu a Ikemetseng?
Litaba
- Kakaretso
- Ho utloisisa maloetse a ikemetseng
- Maemo a tloaelehileng a autoimmune
- Psoriasis e le lefu le ikemetseng
- Kalafo e shebileng sesole sa 'mele
- Lithethefatsi tsa khale
- Likokoana-hloko
- Bahanyetsi ba TNF
- New biologics
- Psoriasis le kotsi bakeng sa maemo a mang a ikemetseng
- Pono
Kakaretso
Psoriasis ke boemo ba letlalo ba ho ruruha bo khetholloang ka likoekoe tse khubelu tsa letlalo tse koahetsoeng ke makhakhapha a masoeu. Ke boemo bo sa foleng. Matšoao a ka tla 'me a feta,' me a ka fapana ka boima.
Psoriasis ke boemo bo tloaelehileng, bo amang hoo e ka bang liperesente tse tharo tsa baahi ba lefatše. Batho ba ka bang limilione tse 7.4 United States ba na le psoriasis.
Lebaka le tobileng la psoriasis ha le na bonnete. Ho nahanoa hore ke motsoako oa liphatsa tsa lefutso, mabaka a tikoloho le sesole sa hau sa 'mele.
Ho ipapisitsoe le liketsahalo tsa lipatlisiso lilemong tse 'maloa tse fetileng, psoriasis ka kakaretso e khethiloe e le lefu le ikemetseng. Sena se bolela hore lisele tsa sesole sa hau sa 'mele, tse bitsoang lisele tsa T, ka phoso li hlasela lisele tsa letlalo la hau joalo ka bahlaseli ba kantle ho naha. Sena se etsa hore lisele tsa letlalo la hau li ngatafale ka potlako, ho lebisang ho litšobotsi tsa letlalo tsa psoriasis.
Hase bafuputsi bohle ba nahanang hore psoriasis ke boloetse bo ikemetseng. Ba bang ba lumela hore psoriasis ke boemo bo kenelloang ke boits'ireletso. Empa khopolo ea bona ke hore psoriasis e tsoa liphellong tse sa tloaelehang tse amanang le liphatsa tsa lefutso ho libaktheria tsa letlalo.
Ho utloisisa maloetse a ikemetseng
Ka tloaelo sesole sa hau sa 'mele se hlokomela lisele tsa hau' me ha se li hlasele. Ho itšireletsa mafung ke ha sesole sa hau sa 'mele se hlasela lisele tse phetseng hantle ka phoso joalo ka ha eka ke ka ntle ho bahlaseli ba hlaselang' mele oa hau.
Ho na le mafu a fetang a 100 a ikemetseng. Maloetse a mang a autoimmune a kenyelletsa karolo e le 'ngoe feela ea' mele oa hau - joalo ka letlalo la hau ho psoriasis. Tse ling ke tsa tsamaiso, tse amang 'mele oohle oa hau.
Seo mathata ohle a ho itšireletsa mafung a tšoanang le 'ona ke hore a bakoa ke motsoako oa liphatsa tsa lefutso le mabaka a tikoloho.
Hantle hore na liphatsa tsa lefutso le maemo a tikoloho a sebelisana joang ho baka mafu a mangata a fapaneng ke sehlooho sa lipatlisiso tse tsoelang pele.
Ho fihlela joale, se tsejoang ke hore batho ba nang le tšekamelo ea lefutso ea ho itšireletsa mafung ba ka ba le makhetlo a 2 ho isa ho a 5 monyetla oa ho ba le lefu le itšireletsang joalo ka batho ba se nang liphatsa tsa lefutso.
Sehlopha sa liphatsa tsa lefutso se amehang se bitsoa histocompatibility complex, e tsejoang ka hore ke HLA. HLA e fapane ho motho e mong le e mong.
Tšekamelo ea lefutso ea ho itšireletsa mafung e ka sebetsa ka malapeng, empa litho tsa lelapa li ka ba le mathata a fapaneng a boits'oaro. Hape, haeba u na le bothata bo le bong ba ho itšireletsa mafung, u na le kotsi e kholo ea ho fumana e 'ngoe.
Ha ho tsejoe hakaalo ka lintlha tse ikhethileng tsa tikoloho tse bakang lefu le ikemetseng ho motho ea nang le liphatsa tsa lefutso tsa ho itšireletsa mafung.
Maemo a tloaelehileng a autoimmune
Mona ke a mang a mathata a tloaelehileng a ho itšireletsa mafung:
- lefu lena le leng le le leng (karabelo ea gluten)
- mofuta oa 1 lefu la tsoekere
- mafu a ho ruruha a mala, ho kenyeletsoa le a Crohn's
- lupus (systemic lupus erythematosus, e amang letlalo, liphio, manonyeletso, boko le litho tse ling)
- ramatiki ea ramatiki (ho ruruha ha manonyeletso)
- Sjögren's syndrome (ho omella molomong oa hao, mahlo le libaka tse ling)
- vitiligo (tahlehelo ea 'mala oa letlalo, o bakang matheba a masoeu)
Psoriasis e le lefu le ikemetseng
Boholo ba bo-rasaense kajeno ba lumela hore psoriasis ke lefu le itšireletsang mafung. Ke khale ho tsebahala hore boits'ireletso ba mmele bo kentse letsoho ho psoriasis. Empa mochini o nepahetseng ha o na bonnete.
Lilemong tse mashome a mabeli tse fetileng, lipatlisiso li netefalitse hore liphatsa tsa lefutso le lihlopha tsa liphatsa tsa lefutso tse amanang le psoriasis li arolelanoa le mathata a tsebahalang a autoimmune. Patlisiso e boetse e netefalitse hore lithethefatsi tse itšireletsang mafung ke kalafo e ncha e sebetsang ea psoriasis. Lithethefatsi tsena li sebetsa ka ho hatella sesole sa 'mele se hlaselang lisele tse phetseng hantle.
Lipatlisiso li ntse li tsoela pele ka karolo ea lisele tsa T tsa sesole sa 'mele ho psoriasis. Lisele tsa T ke “masole” a sesole sa 'mele ao ka tloaelo a loantšang tšoaetso. Ha lisele tsa T li thunya hampe 'me ho e-na le hoo li hlasela letlalo le phetseng hantle, li ntša liprotheine tse khethehileng tse bitsoang li-cytokine. Tsena li etsa hore lisele tsa letlalo li ngatafale 'me li hahe letlalong la hao,' me sena se baka lisosa tsa psoriatic.
Sengoloa sa 2017 se tlaleha ka lipatlisiso tse ncha tse supileng tšebelisano ea lisele tse ling tsa T le li-interleukin tse seng li tsebahala hore li kentse letsoho ntlafatsong ea psoriasis. Joalo ka ha ho tsejoa haholoanyane, ho ka khonahala ho hlahisa mekhoa e mecha ea kalafo ea lithethefatsi.
Kalafo e shebileng sesole sa 'mele
Kalafo ea psoriasis e ipapisitse le mofuta le ho tiea ha boemo, bophelo bo botle ba hau ka kakaretso le lintlha tse ling.
Mona ke mekhoa e fapaneng ea kalafo e shebileng lintlha tse itseng masoleng a mmele a bakang ho ruruha. Tsena li sebelisoa hangata ha matšoao a hau a psoriasis a le mahareng ho isa ho a matla. Hlokomela hore meriana e mecha e theko e phahameng haholo.
Lithethefatsi tsa khale
Lithethefatsi tse peli tsa khale tse sebelisetsoang ho hatella sesole sa 'mele le matšoao a hlakileng a psoriasis ke methotrexate le cyclosporine. Tsena ka bobeli lia sebetsa, empa li na le litla-morao tse chefo ha li sebelisoa nako e telele.
Likokoana-hloko
Bahanyetsi ba TNF
Moriana oa morao tjena o habile ntho e bakang ho ruruha ho bitsoang tumor necrosis factor (TNF). TNF ke cytokine e entsoeng ka likarolo tsa sesole sa 'mele joalo ka lisele tsa T. Lithethefatsi tsena tse ncha li bitsoa bahanyetsi ba TNF.
Lithethefatsi tse khahlanong le TNF lia sebetsa, empa li tlase ho feta biologics e ncha. Lithethefatsi tse khahlanong le TNF li kenyelletsa:
- adalimumab (Humira)
- etanercept (Enbrel)
- infliximab (Khopotso)
- pegol ea setifikeiti (Cimzia)
New biologics
Lits'oants'o tsa morao-rao tsa biologics li shebile le ho thibela lisele tse khethehileng tsa T le li-interleukin tse amehang ho psoriasis. Li-biologics tse tharo tse lebisitseng IL-17 li amohetsoe ho tloha 2015:
- secukinumab (Cosentyx)
- ixekizumab (Taltz)
- brodalumab (Siliq)
Lithethefatsi tse ling li ikemiselitse ho thibela tsela e 'ngoe ea interleukin (I-23 le IL-12):
- ustekinuman (Stelara) (IL-23 le IL-12)
- guselkumab (Tremfya) (IL-23)
- tildrakizumab-asmn (Ilumya) (IL-23)
- risankizumab-rzaa (Skyrizi) (IL-23)
Li-biologics tsena li ipakile li bolokehile ebile li sebetsa hantle.
Psoriasis le kotsi bakeng sa maemo a mang a ikemetseng
Ho ba le lefu le le leng le ikemetseng le kang "psoriasis" ho u beha bakeng sa ho hlaseloa ke lefu le leng le ikemetseng. Kotsi e eketseha haeba psoriasis ea hau e le matla.
Lihlopha tsa liphatsa tsa lefutso tse u lebisang ho ba le bothata ba ho itšireletsa mafung li tšoana le mefuta e fapaneng ea maloetse a ikemetseng. Mekhoa e meng ea ho ruruha le lintlha tsa tikoloho le tsona lia tšoana.
Mathata a mantlha a autoimmune a amanang le psoriasis ke:
- psoriatic arthritis, e amang batho ba 30 ho isa ho 33 lekholong ba nang le ramatiki
- ramatiki ea ramatiki
- lefu lena le leng
- Lefu la Crohn le mafu a mang a mala
- lefu la sclerosis
- lupus (systemic lupus erythematosus kapa SLE)
- autoimmune lefu la qoqotho
- Lefu la Sjögren
- ho lahleheloa ke moriri ka boithaopo (alopecia areata)
- mpoli pemphigoid
E nang le psoriasis e na le ramatiki ea ramatiki.
Kamano ea psoriasis le mafu a mang a ikemetseng ke sehlooho sa thuto e tsoelang pele. Hape ho ithutoang ke kamano ea psoriasis le litefiso tse phahameng tsa lefu ho tsoa maloetseng ao.
Pono
Pono ea batho ba nang le psoriasis e ntle haholo. Boemo bona bo ke ke ba phekoloa, empa kalafo ea hajoale hangata e ka boloka matšoao a laoloa.
Patlisiso ea bongaka e ntse e tsoela pele ho fumana lintlha tse ling ka lisosa tsa psoriasis le mathata a mang a autoimmune. Litšibollo tsena tse ncha li thusa ho nts'etsopele ha litlhare tse ncha tse shebileng ka kotloloho le ho thiba maloetse.
Mohlala, lithethefatsi tse ling tse ngata tse ncha tse lebisang ho interleukin-23 joale li litekong tsa bongaka. Mekhoa e meng e mecha e kanna ea hlaha lipatlisisong tse tsoelang pele mabapi le mathata a boits'oaro ba mmele ka kakaretso.
Bua le ngaka ea hau ka ho nka karolo litekong tse tsoelang pele tsa bongaka le ka liphetoho tse ncha. U kanna ua batla ho kenela sehlopha sa tšehetso sa psoriasis / PsA sa inthaneteng.