Teko ea HER2 (Kankere ea Lebele)

Litaba

• Tlhahlobo ea kankere ea matsoele ea HER2 ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea kankere ea matsoele ea HER2?
• Ho etsahalang nakong ea tlhahlobo ea kankere ea matsoele ea HER2?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea mofets'e oa HER2?
• Litšupiso

Tlhahlobo ea kankere ea matsoele ea HER2 ke eng?

HER2 e emetse human epidermal growth factor receptor 2. Ke jini e etsang hore protheine e fumanoe holim a lisele tsohle tsa matsoele. E ameha kholo e tloaelehileng ea lisele.

Liphatsa tsa lefutso ke likarolo tsa mantlha tsa lefutso, tse fetisitsoeng ke 'm'ao le ntate oa hau. Mefuteng e meng ea mofets'e, haholo kankere ea matsoele, liphatsa tsa lefutso tsa HER2 lia fetoha (li ea fetoha) ebe li etsa likopi tse ling tsa lefutso. Ha sena se etsahala, liphatsa tsa lefutso tsa HER2 li etsa protheine e ngata haholo ea HER2, e etsa hore lisele li arohane le ho hola kapele haholo.

Kankere e nang le liprotheine tse ngata tsa HER2 e tsejoa e le HER2-positive. Kankere e nang le liprotheine tse tlase e tsejoa e le HER2-negative. Hoo e ka bang karolo ea 20 lekholong ea kankere ea matsoele e na le HER2-positive.

Tlhahlobo ea HER2 e sheba mohlala oa lisele tsa hlahala. Litsela tse tloaelehileng ho fetisisa tsa ho hlahloba lisele tsa hlahala ke tsena:

• Ho etsa liteko tsa Immunohistochemistry (IHC) ho lekanya protheine ea HER2 holima lisele
• Teko ea fluorescence in situ hybridization (FISH) e sheba likopi tse ling tsa lefutso la HER2

Mefuta ka bobeli ea liteko e ka tseba hore na u na le mofetše oa HER2. Kalafo e shebileng haholo mofetše oa matsoele oa HER2 e ka sebetsa hantle.

Mabitso a mang: human epidermal growth factor receptor 2, ERBB2 amplification, HER2 overexpression, HER2 / neu liteko

E sebelisetsoa eng?

Tlhahlobo ea HER2 e sebelisoa haholo ho fumana hore na mofetše o na le HER2-positive. Hape ka linako tse ling e sebelisoa ho bona hore na mofetše o arabela kalafong kapa hore na mofetše o khutlile kamora kalafo.

Hobaneng ha ke hloka tlhahlobo ea kankere ea matsoele ea HER2?

Haeba u fumanoe u e-na le mofetše oa matsoele, u kanna oa hloka tlhahlobo ena ho fumana hore na mofetše oa hau o na le HER2 kapa HER2-negative. Haeba u se u ntse u alafshoa ke mofetše oa matsoele oa HER2, u ka hloka tlhahlobo ena ho:

• Fumana hore na kalafo ea hau ea sebetsa. Maemo a tloaelehileng a HER2 a ka bolela hore o arabela kalafo. Maemo a phahameng a ka bolela hore kalafo ha e sebetse.
• Fumana hore na mofetše o khutlile kamora kalafo.

Ho etsahalang nakong ea tlhahlobo ea kankere ea matsoele ea HER2?

Boholo ba liteko tsa HER2 bo kenyelletsa ho nka sampole ea lisele tsa hlahala ka mokhoa o bitsoang biopsy. Ho na le mefuta e meraro ea mantlha ea lits'ebetso tsa biopsy:

• Phofo e ntle ea nale, e sebedisang nale e tshesane haholo ho ntsha sampole ya disele tsa matsoele kapa lero
• Nete ​​ea biopsy, e sebelisang nale e kholo ho tlosa sampole
• Ho buoa biopsy, e tlosang sampole ts'ebetsong e nyane ea bakuli

Takatso e ntle ea nale le li-biopsies tsa mantlha tsa nale hangata ho kenyelletsa mehato e latelang:

• U tla robala ka lehlakore kapa u lule tafoleng ea liteko.
• Mofani oa tlhokomelo ea bophelo o tla hloekisa sebaka sa biopsy mme a se ente ka moriana o thethefatsang e le hore o se utloe bohloko nakong ea ts'ebetso.
• Hang ha sebaka seo se felloa ke matla, mofani oa thepa o tla kenya nale e ntle ea aspiration kapa nale ea mantlha ea biopsy sebakeng sa biopsy ebe o tlosa sampuli ea lisele kapa mokelikeli.
• U kanna oa utloa khatello e nyane ha sampole e huloa.
• Khatello e tla sebelisoa sebakeng sa biopsy ho fihlela mali a emisa.
• Mofani oa hau o tla kenya bandage e nyopa sebakeng sa biopsy.

Ka biopsy ea ho buoa, Ngaka e buoang e tla itšeha hanyane letlalong la hao ho tlosa leqhubu la letsoele kaofela kapa karolo ea lona. Ka linako tse ling biopsy ea ho buoa e etsoa haeba hlama e ke ke ea fihleloa ka nalane ea nale. Hangata li-biopsies tsa ho buoa li kenyelletsa mehato e latelang.

• U tla robala tafoleng ea ts'ebetso. Ho ka beoa IV (mohala o kenang methapong) letsohong kapa letsohong.
• U kanna ua fuoa moriana, o bitsoang sedative, ho u thusa ho phomola.
• U tla fuoa anesthesia ea lehae kapa e akaretsang hore u se ke oa utloa bohloko nakong ea ts'ebetso.
  • Bakeng sa anesthesia ea lehae, mofani oa tlhokomelo ea bophelo o tla kenya setša sa biopsy ka meriana ho felisa sebaka seo.
  • Bakeng sa thethebatso e akaretsang, setsebi se bitsoang anesthesiologist se tla u fa moriana hore o tle o tsebe letho nakong ea ts'ebetso.
• Hang ha sebaka sa biopsy se felloa ke matla kapa u sa tsebe letho, ngaka e buoang e tla poma hanyenyane ka letsoeleng ebe e tlosa karolo kapa kotola kaofela. Lisele tse ling tse potileng hlama le tsona li ka tlosoa.
• Sehiloeng letlalong la hao se tla koaloa ka lithupa kapa likotoana tsa khomaretsi.

Mofuta oa biopsy oo u nang le oona o tla itšetleha ka lintlha tse fapaneng, ho kenyeletsoa boholo le sebaka sa hlahala. HER2 le eona e ka lekanyetsoa tekong ea mali, empa tlhahlobo ea mali ea HER2 ha e so pakoe e le molemo ho bakuli ba bangata. Kahoo hangata ha e khothalletsoe.

Kamora hore sampuli ea hau ea lisele e nkuoe, e tla lekoa ka e 'ngoe ea litsela tse peli:

• Litekanyo tsa protheine ea HER2 li tla lekanyetsoa.
• Mohlala o tla shejoa bakeng sa likopi tse ling tsa lefutso la HER2.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

U ke ke ua hloka litokisetso tse khethehileng haeba u fumana anesthesia ea lehae (ho koaloa ha sebaka sa biopsy). Haeba u fumana anesthesia ka kakaretso, mohlomong u tla hloka ho itima lijo (u se ke ua ja kapa ua noa) lihora tse 'maloa pele u etsoa opereishene. Ngaka ea hao e buoang e tla u fa litaelo tse tobileng. Hape, haeba u fumana moriana o thethefatsang kapa o thetsang, etsa bonnete ba hore o hlophisa hore motho e mong au khannele hae. O kanna oa ba groggy mme oa ferekana kamora ho tsoha ts'ebetsong.

Na ho na le likotsi tsa tlhahlobo?

U kanna oa ba le maqeba kapa ho tsoa mali hanyane sebakeng sa biopsy. Ka linako tse ling sebaka seo se a tšoaetsoa. Haeba seo se etsahala, o tla phekoloa ka lithibela-mafu. Biopsy ea ho buoa e ka baka bohloko le pherekano tse ling. Mofani oa hao oa tlhokomelo ea bophelo a ka u khothaletsa kapa a u fa meriana ho u thusa hore u ikutloe u le betere.

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Haeba liprotheine tsa HER2 li phahame ho feta likopi tse tloaelehileng kapa tse eketsehileng tsa lefutso la HER2 li fumaneha, mohlomong ho bolela hore o na le mofetše oa HER2. Haeba liphetho tsa hau li bontša palo e tloaelehileng ea protheine ea HER2 kapa lipalo tse tloaelehileng tsa liphatsa tsa lefutso tsa HER2, mohlomong o na le mofetše oa HER2.

Haeba liphetho tsa hau li ne li sa hlake hantle kapa li le mpe, mohlomong o tla botsoa hape, ekaba o sebelisa sampole e fapaneng ea hlahala kapa o sebelisa mokhoa o fapaneng oa liteko. Hangata, IHC (ho etsa liteko tsa protheine ea HER2) e etsoa pele, e lateloe ke FISH (ho lekoa likopi tse ling tsa lefutso). Tlhahlobo ea IHC ha e theko e tlase ebile e fana ka liphetho tse potlakileng ho feta FISH. Empa litsebi tse ngata tsa matsoele li nahana hore tlhahlobo ea FISH e nepahetse ho feta.

Kalafo bakeng sa mofetše oa matsoele oa HER2 e ka fokotsa lihlahala tsa mofetše haholo, ka litlamorao tse fokolang haholo. Litlhare tsena ha li sebetse ho mofetše oa HER2-negative.

Haeba u alafshoa ke mofetše oa HER2, liphetho tse tloaelehileng li ka bolela hore u arabela kalafo. Liphetho tse bonts'ang li phahame ho feta chelete e tloaelehileng li ka bolela hore kalafo ea hau ha e sebetse, kapa hore mofetše o khutlile kamora kalafo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea mofets'e oa HER2?

Le ha e atile haholo ho basali, mofets'e oa matsoele, ho kenyeletsoa le mofetše oa matsoele oa HER2, le ona o ka ama banna. Haeba monna a fumanoe a na le mofetše oa matsoele, ho ka khothaletsoa tlhahlobo ea HER2.

Ntle le moo, banna le basali ba ka hloka tlhahlobo ea HER2 haeba ba fumanoe ba na le mofetše o itseng oa mpa le 'metso. Kankere ena ka linako tse ling e na le liprotheine tse ngata tsa HER2 mme e ka arabela hantle kalafong ea mofets'e ea HER2.

Litšupiso

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Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.