Dopamine Deficiency Syndrome ke eng?

Litaba

• Matšoao ke afe?
• Seemo see se bakoa ke eng?
• Ke mang ea kotsing?
• E fumanoa joang?
• E alafshoa joang?
• E ama nako e telele ea bophelo joang?

Na see se atile?

Dopamine defence syndrome ke boemo bo sa tloaelehang ba lefutso bo nang le linyeoe tse 20 feela tse tiisitsoeng. E boetse e tsejoa e le dopamine transporter defence syndrome le infantile parkinsonism-dystonia.

Boemo bona bo ama bokhoni ba ngoana ba ho tsamaisa 'mele le mesifa ea bona. Le ha matšoao a hlaha hangata bongoaneng, a kanna a se hlahe ho fihlela hamorao bongoaneng.

Matšoao a tšoana le a mathata a mang a motsamao, joalo ka lefu la bana la Parkinson. Ka lebaka la sena, hangata bafuputsi ba bang le bona ba nahana hore e atile haholo ho feta kamoo ho neng ho nahanoa pele.

Boemo bona bo tsoela pele, ho bolelang hore bo mpefala ha nako e ntse e ea. Ha ho na pheko, kahoo kalafo e shebile ho sebetsana le matšoao.

Tsoela pele ho bala ho ithuta haholoanyane.

Matšoao ke afe?

Matšoao hangata a ts'oana ho sa tsotelehe hore na ba na le lilemo tse kae. Tsena li ka kenyelletsa:

• mesifa ya mesifa
• mesifa
• ho thothomela
• mesifa e tsamaea butle haholo (bradykinesia)
• ho satalla ha mesifa (ho satalla)
• pipitlelano
• bothata ba ho ja le ho koenya
• ho thatafalloa ho bua le ho theha mantsoe
• mathata a ho tshwara mmele o eme hantle
• mathata le botsitso ha o eme o tsamaya
• motsamao o sa laoleheng oa mahlo

Matšoao a mang a kenyeletsa:

• lefu la reflux la gastroesophageal (GERD)
• ho tšoaetsoa hangata ke pneumonia
• ho thatafalloa ho robala

Seemo see se bakoa ke eng?

Ho ea ka Laeborari ea Naha ea Bongaka ea U.S., lefu lena la liphatsa tsa lefutso le bakoa ke liphetoho tse etsahalang ho SLC6A3 liphatsa tsa lefutso. Jini ena e kenya letsoho ho theheng protheine ea Transporter Transporter. Protheine ena e laola hore na dopamine e tsamaisoa hakae ho tloha bokong ho ea liseleng tse fapaneng.

Dopamine e nka karolo nthong e ngoe le e ngoe ho tloha ts'ebetsong le maikutlong, ho fihlela bokhoni ba ho laola metsamao ea 'mele. Haeba palo ea dopamine liseleng e le tlase haholo, e ka ama taolo ea mesifa.

Ke mang ea kotsing?

Dopamine defence syndrome ke bothata ba lefutso, bo bolelang hore motho o tsoetsoe a e-na le eona. Lebaka le ka sehloohong la likotsi ke liphatsa tsa lefutso tsa batsoali ba ngoana. Haeba batsoali ka bobeli ba na le kopi e le 'ngoe ea liphetoho SLC6A3 liphatsa tsa lefutso, ngoana oa bona o tla amohela likopi tse peli tsa lefutso le fetotsoeng mme a rue lefu lena.

E fumanoa joang?

Hangata, ngaka ea ngoana oa hau e ka etsa tlhahlobo ea lefu kamora ho bona mathata afe kapa afe ao ba ka bang le ona ka botsitso kapa motsamao. Ngaka e tla netefatsa tlhahlobo eo ka ho nka sampole ea mali ho etsa liteko tsa maemo a lefutso.

Ba kanna ba nka sampole ea mokelikeli oa cerebrospinal ho batla liasiti tse amanang le dopamine. Sena se tsejoa e le.

E alafshoa joang?

Ha ho na moralo oa kalafo o hlophisitsoeng bakeng sa boemo bona. Hangata ho hlokahala liteko le liphoso ho fumana hore na ke meriana efe e ka sebelisoang ho laola matšoao.

ba bile le katleho e kholo ho sebetsaneng le mathata a mang a motsamao a amanang le tlhahiso ea dopamine. Ka mohlala, levodopa e sebelisitsoe ka katleho ho kokobetsa matšoao a lefu la Parkinson.

Ropinirole le pramipexole, e leng bahanyetsi ba dopamine, ba sebelisitsoe ho phekola lefu la Parkinson ho batho ba baholo. Bafuputsi ba sebelisitse meriana ena ho lefu la khaello ea dopamine. Leha ho le joalo, ho hlokahala lipatlisiso tse ling ho fumana litlamorao tse ka bang teng tsa nako e khuts'oane le e telele.

Mekhoa e meng ea ho phekola le ho sebetsana le matšoao e ts'oana le ea mathata a mang a motsamao. Sena se kenyelletsa litlhare le phetoho ea bophelo ho li alafa:

• ho thatafala hoa mesifa
• tšoaetso ea matšoafo
• mathata a ho hema
• GERD
• pipitlelano

E ama nako e telele ea bophelo joang?

Masea le bana ba nang le bofokoli ba bapalami ba dopamine ba ka ba le nako e khuts'oane ea bophelo. Lebaka ke hore ba pepesehetse tšoaetso ea matšoafo e sokelang bophelo le mafu a mang a phefumolohang.

Maemong a mang, pono ea ngoana e ntle haholo haeba matšoao a bona a sa hlahe nakong ea bongoana.