Teko ea Antineutrophil Cytoplasmic Antibodies (ANCA)

Litaba

• Teko ea antineutrophil cytoplasmic antibodies (ANCA) ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea ANCA?
• Ho etsahalang nakong ea teko ea ANCA?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea ANCA?
• Litšupiso

Teko ea antineutrophil cytoplasmic antibodies (ANCA) ke eng?

Teko ena e sheba li-anti -utrophil cytoplasmic antibodies (ANCA) maling a hau. Masole a 'mele ke liprotheine tseo sesole sa hau sa' mele se li etsang ho loants'a lintho tse kantle ho naha joalo ka livaerase le libaktheria. Empa li-ANCA li hlasela lisele tse phetseng hantle tse tsejoang e le neutrophils (mofuta oa sele e tšoeu ea mali) ka phoso. Sena se ka lebisa bothateng bo tsejoang e le autoimmune vasculitis. Ho itšireletsa mafung vasculitis ho baka ho ruruha le ho ruruha ha methapo ea mali.

Methapo ea mali e tsamaisa mali ho tloha pelong ea hau ho ea lithong tsa hau, lisele le lits'ebetso tse ling, ebe e khutla hape. Mefuta ea methapo ea mali e kenyelletsa methapo ea methapo, methapong le methapo ea kutlo. Ho ruruha methapong ea mali ho ka baka mathata a tebileng a bophelo bo botle. Mathata a fapana ho latela hore na methapo ea mali le litsamaiso tsa 'mele li amehile.

Hona le mefuta e 'meli e meholo ea ANCA. E 'ngoe le e' ngoe e lebisa protheine e itseng ka har'a lisele tse tšoeu tsa mali:

• PANCA, e shebileng protheine e bitsoang MPO (myeloperoxidase)
• cANCA, e shebileng protheine e bitsoang PR3 (proteinase 3)

Teko e ka bontsha hore na o na le mofuta o le mong kapa bobedi ba masole a mmele. Sena se ka thusa mofani oa hao oa tlhokomelo ea bophelo ho fumana le ho phekola bothata ba hau.

Mabitso a mang: Lisireletsi tsa ANCA, cANCA pANCA, lithibela-mafu tsa cytoplasmic neutrophil, serum, anticytoplasmic autoantibodies

E sebelisetsoa eng?

Hangata ho sebelisoa tlhahlobo ea ANCA ho fumana hore na o na le mofuta oa vasculitis e itšireletsang mafung. Hona le mefuta e fapaneng ea lefu lena. Kaofela li baka ho ruruha le ho ruruha ha methapo ea mali, empa mofuta o mong le o mong o ama methapo ea mali e fapaneng le likarolo tsa 'mele. Mefuta ea autoimmune vasculitis e kenyelletsa:

• Granulomatosis e nang le polyangiitis (GPA), eo pele e neng e bitsoa lefu la Wegener. Hangata e ama matšoafo, liphio le lisene.
• Microscopic polyangiitis (MPA). Boloetse bona bo ka ama litho tse 'maloa' meleng, ho kenyelletsa le matšoafo, liphio, tsamaiso ea methapo le letlalo.
• Granulomatosis e nang le eosinophilic le polyangiitis (EGPA), eo pele e neng e bitsoa Churg-Strauss syndrome. Boloetse bona hangata bo ama letlalo le matšoafo. Hangata e baka asthma.
• Polyarteritis nodosa (PAN). Hangata lefu lena le ama pelo, liphio, letlalo le tsamaiso ea methapo.

Teko ea ANCA e kanna ea sebelisoa ho lekola kalafo ea mathata ana.

Hobaneng ha ke hloka tlhahlobo ea ANCA?

Mofani oa hao oa tlhokomelo ea bophelo a ka odara tlhahlobo ea ANCA haeba u na le matšoao a autoimmune vasculitis. Matšoao a kenyelletsa:

• Feberu
• Mokhathala
• Ho fokotsa boima ba 'mele
• Mahlaba a mesifa le / kapa manonyeletso

Matšoao a hau a ka ama setho se le seng kapa tse 'maloa' meleng oa hau. Litho tse atisang ho ameha le matšoao ao li a bakang a kenyelletsa:

• Mahlo
  • Bofubelu
  • Pono e lerootho
  • Ho lahleheloa ke pono
• Litsebe
  • Ho lla litsebeng (tinnitus)
  • Ho lahleheloa ke kutlo
• Libe
  • Bohloko ba sinus
  • Nko ea metsi
  • Nko e tsoa mali
• Letlalo
  • Li-rash
  • Liso kapa liso, mofuta oa seso se tebileng se liehang ho fola le / kapa se ntseng se khutla
• Matšoafo
  • Khohlela
  • Ho hema ka thata
  • Bohloko ba sefuba
• Liphio
  • Mali ka morong
  • Moroto o nang le foam, o bakoang ke liprotheine tse teng morong
• Tsamaiso ea methapo
  • Ho ba lerootho le ho hlohlona likarolong tse fapaneng tsa 'mele

Ho etsahalang nakong ea teko ea ANCA?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea ANCA.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Haeba liphetho tsa hau li ne li le mpe, ho bolela hore matšoao a hau mohlomong ha a bakoe ke autoimmune vasculitis.

Haeba liphetho tsa hau li ne li le ntle, ho kanna ha bolela hore o na le autoimmune vasculitis. E ka bonts'a hape haeba li-cANCA kapa li-pANCA li fumanoe. Sena se ka thusa ho tseba hore na u na le mofuta ofe oa vasculitis.

Ho sa tsotelehe hore na ke li-antibodies tsa mofuta ofe tse fumanoeng, o kanna oa hloka tlhahlobo e tlatselletsang, e tsejoang ka hore ke biopsy, ho netefatsa phumano. Biopsy ke mokhoa o tlosang sampole e nyane ea lisele kapa lisele bakeng sa tlhahlobo. Mofani oa hao oa tlhokomelo ea bophelo a ka odara liteko tse ling ho lekanya palo ea ANCA maling a hau.

Haeba hona joale u alafshoa ke "autoimmune vasculitis", sephetho sa hau se ka bonts'a hore na kalafo ea hau ea sebetsa.

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea ANCA?

Haeba liphetho tsa hau tsa ANCA li bonts'a u na le vasculitis e ikemetseng, ho na le mekhoa ea ho phekola le ho laola boemo bona. Kalafo e ka kenyelletsa meriana, liphekolo tse tlosang li-ANCA nakoana maling a hau, le / kapa ho buuoa.

Litšupiso

1. Allina Health [Inthanete]. Minneapolis: Bophelo bo Botle ba Allina; Tekanyo ea C-ANCA; [e qotsitsoeng ka la 3 Mots'eanong 3]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://account.allinahealth.org/library/content/49/150100
2. Allina Health [Inthanete]. Minneapolis: Bophelo bo Botle ba Allina; Tekanyo ea P-ANCA; [e qotsitsoeng ka la 3 Mots'eanong 3]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://account.allinahealth.org/library/content/49/150470
3. Kliniki ea Cleveland [Inthanete]. Cleveland (OH): Kliniki ea Cleveland; c2019. Lisosa tsa Maoto le Maoto; [e qotsitsoeng ka la 3 Mots'eanong 3]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Masole a mmele a ANCA / MPO / PR3; [e ntlafalitsoeng ka la 2019 Mphalane 29; e qotsitsoeng 2019 ka la 3 Mots'eanong]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Tlhaho; [e ntlafalitsoeng 2017 Jul 10; e qotsitsoeng 2019 ka la 3 Mots'eanong]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/glossary/biopsy
6. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Vasculitis; [e ntlafalitsoeng 2017 Sep 8; e qotsitsoeng 2019 ka la 3 Mots'eanong]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Se kopane le Sesebelisoa se Nyane sa Vasculitis. Ke ngaka ea malapa [Inthanete]. 2002 Mmesa 15 [e qotsitsoeng ka la 3 Mots'eanong 3]; 65 (8): 1615-1621. E fumaneha ho tsoa ho: https://www.aafp.org/afp/2002/0415/p1615.html
8. Mayo Clinic Laboratories [Inthanete]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2019. ID ea Teko: ANCA: Cytoplasmic Neutrophil Antibodies, Serum: Clinical and Interpretive; [e qotsitsoeng ka la 3 Mots'eanong 3]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng ka la 3 Mots'eanong 3]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Vasculitis; [e qotsitsoeng ka la 3 Mots'eanong 3]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Ho itšireletsa mafung [Inthanete]. 2005 Feb [e qotsitsoeng 2019 ka la 3 Mots'eanong]; 38 (1): 93-103. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pubmed/15804710
12. Setsi sa Liphio sa UNC [Marang-rang]. Hill ea Chapel (NC): Setsi sa Liphio sa UNC; c2019. Moferefere oa Vasculitis; [e ntlafalitsoeng 2018 Sep; e qotsitsoeng 2019 ka la 3 Mots'eanong]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/anca-vasculitis

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.