Teko ea mali ea Cortisol

Teko ea mali ea cortisol e lekanya boemo ba cortisol maling. Cortisol ke hormone ea steroid (glucocorticoid kapa corticosteroid) e hlahisoang ke tšoelesa ea adrenal.

Cortisol le eona e ka lekanyetsoa ho sebelisoa tlhahlobo ea moroto kapa ea mathe.

Ho hlokahala sampole ea mali.

Ngaka ea hau e kanna ea u etsa tlhahlobo hoseng. Sena se bohlokoa, hobane boemo ba cortisol bo fapana letsatsi lohle.

U ka kopuoa hore u se ke ua ikoetlisa ka matla letsatsi pele ho tlhahlobo.

U kanna oa bolelloa hore u emise ho noa meriana ka nakoana e ka amang tlhahlobo, ho kenyelletsa:

• Lithethefatsi tse khahlanong le ho inkela
• Estrogen
• Li-glucocorticoids tse entsoeng ke batho, tse kang hydrocortisone, prednisone le prednisolone
• Androgens

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba ikutloa feela ho hlaba kapa ho hlaba. Kamora moo, ho kanna ha ba le ho longoa kapa ho longoa hanyenyane. Haufinyane sena sea fela.

Teko e etsoa ho lekola tlhahiso ea cortisol e eketsehang kapa e fokotsehileng. Cortisol ke hormone ea glucocorticoid (steroid) e tsoang ho adrenal gland ho arabela adrenocorticotropic hormone (ACTH). ACTH ke hormone e tsoang lethong la pituitary bokong.

Cortisol e ama litsamaiso tse ngata tse fapaneng tsa 'mele. E bapala karolo ho:

• Khōlo ea masapo
• Ho laola khatello ea mali
• Ts'ebetso ea immune system
• Metabolism ea mafura, lik'habohaedreite le protheine
• Ts'ebetso ea methapo e sebetsa
• Karabo ea khatello ea maikutlo

Maloetse a fapaneng, joalo ka Cushing syndrome le lefu la Addison, a ka lebisa ho hlahiseng cortisol e ngata haholo kapa e nyane haholo. Ho lekanya boemo ba cortisol ea mali ho ka thusa ho fumana maemo ana. E boetse e lekantsoe ho lekola hore na litšoelesa tsa pituitary le adrenal li sebetsa hantle hakae.

Hangata liteko li etsoa pele le hora e le 'ngoe ka mora ho entoa ka moriana o bitsoang ACTH (cosyntropin). Karolo ena ea teko e bitsoa teko ea ho hlasimolla ea ACTH. Ke teko ea bohlokoa e thusang ho lekola ts'ebetso ea litšoelesa tsa pituitary le adrenal.

Maemo a mang ao tlhahlobo e ka laeloang bakeng sa ona a kenyelletsa:

• Mathata a maholo a adrenal, boemo bo sokelang bophelo bo etsahalang ha cortisol e sa lekana
• Sepsis, bokuli boo 'mele o nang le karabelo e matla ho libaktheria kapa likokoana-hloko tse ling
• Khatello ea mali e tlase

Litekanyetso tse tloaelehileng tsa sampole ea mali e nkuoeng ka 8 hoseng ke 5 ho isa ho 25 mcg / dL kapa 140 ho isa ho 690 nmol / L.

Litekanyetso tse tloaelehileng li latela nako ea letsatsi le boemo ba bongaka. Mekhahlelo e tloaelehileng e ka fapana hanyane hara lilaboratori tse fapaneng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li ka leka mefuta e fapaneng. Bua le ngaka ea hau ka se boleloang ke sephetho sa hau sa liteko.

Boemo bo phahameng ho feta bo tloaelehileng bo ka supa:

• Cushing lefu, moo tšoelesa ea pituitary e etsang ACTH e ngata haholo ka lebaka la kholo e fetelletseng ea tšoelesa ea "pituitary" kapa "" "" "tumor" ho "pituitary gland".
• Ectopic Cushing syndrome, moo hlahala e ka ntle ho litšoelesa tsa pituitary kapa adrenal e etsang ACTH e ngata haholo
• Hlahala ea adrenal gland e hlahisang cortisol e ngata haholo
• Khatello ea maikutlo
• Boloetse bo bohloko

Boemo bo tlase ho feta bo tloaelehileng bo ka supa:

• Addison lefu, moo litšoelesa tsa adrenal li sa hlahiseng cortisol e lekaneng
• Hypopituitarism, moo tšoelesa ea pituitary e sa supeng tšoelesa ea adrenal ho hlahisa cortisol e lekaneng
• Phekolo ea ts'ebetso e tloaelehileng ea pituitary kapa adrenal ke meriana ea glucocorticoid e kenyeletsang lipilisi, litlolo tsa letlalo, mahlo a mahlo, li-inhalers, liente tse kopanetsoeng, chemotherapy

Ha ho na kotsi e kholo ea ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho nka mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tse amanang le ho huloa mali li nyane, empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Li-punctures tse ngata ho fumana methapo
• Hematoma (mali a bokellanang ka tlasa letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Serum cortisol

CC ea Chernecky, Berger BJ. Cortisol - lero la mali kapa serum. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 388-389.

Stewart PM, Newell-Price JDC. Karolo ea adrenal cortex. Ka: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, bahlophisi. Buka ea Williams ea Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 15.