Teko ea Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) ke protheine e thusang lisele tse khubelu tsa mali ho sebetsa hantle. Teko ea G6PD e sheba palo (ts'ebetso) ea ntho ena liseleng tse khubelu tsa mali.

Ho hlokahala sampole ea mali.

Ha ho litokisetso tse khethehileng hangata tse hlokahalang.

Ha nale e kentsoe ho hula mali, batho ba bang ba utloa bohloko bo itekanetseng. Ba bang ba ikutloa feela ho hlaba kapa ho hlaba. Kamora moo, ho ka ba le ho phatloha kapa ho longoa hanyane. Haufinyane sena sea fela.

Mofani oa hao oa tlhokomelo ea bophelo a ka khothaletsa tlhahlobo ena haeba u na le matšoao a khaello ea G6PD. Sena se bolela hore ha o na ts'ebetso e lekaneng ea G6PD.

Mosebetsi o monyane haholo oa G6PD o lebisa tšenyehong ea lisele tse khubelu tsa mali. Ts'ebetso ena e bitsoa hemolysis. Ha ts'ebetso ena e etsahala ka mafolofolo, e bitsoa sekhetho sa hemolytic.

Likarolo tsa hemolytic li ka bakoa ke tšoaetso, lijo tse itseng (joalo ka linaoa tsa fava), le meriana e meng ho kenyelletsa:

• Lithethefatsi tse sebelisetsoang ho fokotsa feberu
• Nitrofurantoin
• Phenacetin
• Selelekela
• Sulfonamides
• Li-diuretics tsa Thiazide
• Tolbutamide
• Quinidine

Litekanyetso tse tloaelehileng li ea fapana ho latela laboratori e sebelisitsoeng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li leka liteko tse fapaneng. Bua le mofani oa hau ka moelelo oa sephetho sa hau sa liteko.

Liphetho tse sa tloaelehang li bolela hore u na le khaello ea G6PD. Sena se ka baka haemolytic anemia maemong a mang.

Ha ho na kotsi e kholo ea ho nkuoa mali a hau. Methapo le methapo li fapana ka boholo ho tloha ho motho e mong ho ea ho o mong le ho tloha lehlakoreng le leng la 'mele ho ea ho le leng. Ho fumana sampole ea mali ho batho ba bang ho ka ba thata ho feta ho ba bang.

Likotsi tse ling tse amanang le ho huloa mali li nyane, empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Li-punctures tse ngata ho fumana methapo
• Hematoma (mali a hahiloeng ka tlas'a letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Teko ea RBC G6PD; Sesepa sa G6PD

CC ea Chernecky, Berger BJ. Glucose-6-phosphate dehydrogenase (G6PD, G-6-PD), bongata - mali. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 594-595.

Gallagher PG. Hemolytic anemias: lisele tse khubelu tsa lisele tsa mali le likoli tsa metabolism. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 152.