Teko ea CPK isoenzymes

Teko ea creatine phosphokinase (CPK) isoenzymes e lekanya mefuta e fapaneng ea CPK maling. CPK ke enzyme e fumanoang haholo pelong, bokong le mesifa ea masapo.

Ho hlokahala sampole ea mali. Sena se ka nkoa mothapong. Teko e bitsoa venipuncture.

Haeba u le sepetlele, tlhahlobo ena e ka phetoa ho feta matsatsi a 2 kapa a 3. Ho phahama kapa ho oela ho hoholo ha li-isoenzymes tsa CPK kapa CPK ho ka thusa mofani oa tlhokomelo ea bophelo ba hau ho fumana maemo a itseng.

Ha ho litokisetso tse khethehileng tse hlokahalang maemong a mangata.

Bolella mofani oa hau ka meriana eohle eo u e sebelisang. Meriana e meng e ka kena-kenana le sephetho sa liteko. Lithethefatsi tse ka eketsang litekanyo tsa CPK li kenyelletsa tse latelang:

• Joala
• Amphotericin B
• Li-anesthetics tse ling
• K'hok'heine
• Fibrate lithethefatsi
• Lipolelo
• Li-steroid, tse kang dexamethasone

Lethathamo lena ha le kenyelelitsoe kaofela.

U ka utloa bohloko bo fokolang ha nale e kentsoe ho hula mali. Batho ba bang ba utloa feela ho hlaba kapa ho hlaba habohloko. Kamora moo, ho kanna ha ba le ho tsitsipana.

Teko ena e etsoa haeba tlhahlobo ea CPK e bonts'a hore kakaretso ea CPK ea hau e phahame. Teko ea CPK isoenzyme e ka thusa ho fumana mohloli o nepahetseng oa lisele tse senyehileng.

CPK e entsoe ka lintho tse tharo tse fapaneng hanyane:

• CPK-1 (eo hape e bitsoang CPK-BB) e fumanoa haholo bokong le matšoafong
• CPK-2 (eo hape e bitsoang CPK-MB) e fumaneha haholo ka pelong
• CPK-3 (eo hape e bitsoang CPK-MM) e fumanoa haholo mesifa ea masapo

Methati e phahameng ho feta e tloaelehileng ea CPK-1:

Hobane CPK-1 e fumanoa haholo bokong le matšoafong, kotsi ho e 'ngoe ea libaka tsena e ka eketsa maemo a CPK-1. Maemo a eketsehileng a CPK-1 a ka bakoa ke:

• Kankere ea boko
• Kotsi ea boko (ka lebaka la mofuta ofe kapa ofe oa kotsi e kenyeletsang, stroke, kapa ho tsoa mali bokong)
• Phekolo ea motlakase
• Infarction ea pulmonary
• Inkela ka mahahapa

Methati e phahameng ho feta e tloaelehileng ea CPK-2:

Methati ea CPK-2 e phahama lihora tse 3 ho isa ho tse 6 kamora lefu la pelo. Haeba ho se na tšenyo e 'ngoe ea mesifa ea pelo, boemo bo phahama ka lihora tse 12 ho isa ho tse 24 ebe bo khutlela maemong a tloaelehileng ho tloha ho lihora tse 12 ho isa ho tse 48 kamora lefu la lisele.

Maemo a eketsehileng a CPK-2 le ona a ka bakoa ke:

• Likotsi tsa motlakase
• Phetoho ea pelo (tšabo e nang le morero ea pelo ke basebeletsi ba tsa bongaka)
• Kotsi ea pelo (mohlala, ho tsoa kotsing ea koloi)
• Ho ruruha ha mesifa ea pelo hangata ka lebaka la vaerase (myocarditis)
• Bula opereishene ea pelo

Methati e phahameng ho feta e tloaelehileng ea CPK-3 hangata ke sesupo sa ho lemala ha mesifa kapa khatello ea mesifa. E kanna ea ba ka lebaka la:

• Ho senya likotsi
• Tšenyo ea mesifa ka lebaka la lithethefatsi kapa ho se sisinyehe nako e telele (rhabdomyolysis)
• Ho senyeha ha mesifa
• Myositis (masapo a ho ruruha ha mesifa)
• Ho fumana liente tse ngata tsa ente
• Tlhahlobo ea morao-rao ea methapo le mesifa (electromyography)
• Ho oa ha morao tjena
• Ho buuoa haufinyane
• Ho ikoetlisa ka thata

Lintho tse ka amang sephetho sa liteko li kenyelletsa catheterization ea pelo, liente tsa mesifa, opereishene ea morao-rao, le boikoetliso bo matla le ba nako e telele kapa ho holofala.

Tlhahlobo ea Isoenzyme bakeng sa maemo a itseng e nepahetse ka 90%.

Bopa phosphokinase - isoenzymes; Sebopeho sa kinase - isoenzymes; CK - isoenzymes; Lefu la pelo - CPK; Hlakola - CPK

• Teko ea mali

Anderson JL. St segment elevation acute myocardial infarction le mathata a infarction ea "myocardial". Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 73.

Marshall WJ, Day A, Lapsley M.Liprotheine tsa Plasma le li-enzyme. Ka: Marshall WJ, Letsatsi la A, Lapsley M, eds. Clinical k'hemistri. La 8th. Philadelphia, PA: Elsevier; 2017: khaolo ea 16.

Nagaraju K, Gladue HS, Lundberg IE. Maloetse a ho ruruha a mesifa le tse ling tsa myopathies. Ka: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, bahlophisi. Kelley le Firestein's Bookbook ea Rheumatology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2017: khaolo ea 85.

Selcen D. Maloetse a mesifa. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 421.