Khaello ea Ntlha ea VII

Litaba

• Ntlha ea VII e bapala karolo efe ka ho koala mali ho tloaelehileng?
• 1. Vasoconstriction
• 2. Ho theha polaka ea platelet
• 3. Ho thehoa ha polaka ea fibrin
• 4. Pholiso ea maqeba le tšenyo ea polaka ea fibrin
• Ke eng e bakang khaello ea factor VII?
• Matšoao a khaello ea factor VII ke afe?
• Ho haella ha factor VII ho fumanoa joang?
• Ho haella ha factor VII ho alafshoa joang?
• Ho laola ho tsoa mali
• Kalafo ea maemo a ipatileng
• Kalafo ea boits'oaro pele ho ts'ebetso
• Pono ea nako e telele ke efe?

Kakaretso

Ho haella ha factor VII ke lefu la ho koala mali le bakang ho tsoa mali ka mokhoa o fetelletseng kapa nako e telele kamora ho tsoa kotsi kapa ho buuoa. Ka lebaka la khaello ea factor VII, 'mele oa hau ha o hlahise factor VII e lekaneng, kapa ho na le ho hong ho sitisang factor VII ea hau, hangata boemo bo bong ba bongaka.

Ntlha ea VII ke protheine e hlahisoang sebeteng e phethang karolo ea bohlokoa ho thuseng mali a hau ho koala. Ke e 'ngoe ea lintho tse ka bang 20 tse hoamisang mali tse amehang tšebetsong e rarahaneng ea ho hoama ha mali. Ho utloisisa khaello ea factor VII, ho thusa ho utloisisa karolo ea VII e bapalang ho hoama ha mali ho tloaelehileng.

Ntlha ea VII e bapala karolo efe ka ho koala mali ho tloaelehileng?

Mokhoa o tloaelehileng oa ho koala mali o hlaha ka mekhahlelo e mene:

1. Vasoconstriction

Ha methapo ea mali e khaoloa, methapo ea mali e senyehileng hanghang e lula e fokotsa ho lahleheloa ke mali. Joale, methapo ea mali e lemetseng e ntša protheine e bitsoang tissue factor maling. Ho lokolloa ha lisele tsa mmele ho tšoana le mohala oa SOS, ho bontša liplatelete tsa mali le lintlha tse ling tse hoamisa ho itlaleha sebakeng sa kotsi.

2. Ho theha polaka ea platelet

Liplatelete maling ke tsona tsa pele tsa ho fihla sebakeng sa kotsi. Ba ikopanya le lisele tse senyehileng, 'me ba ikopantseng, ba etsa polaka ea nakoana, e bonolo leqebeng. Ts'ebetso ena e tsejoa e le hemostasis ea mantlha.

3. Ho thehoa ha polaka ea fibrin

Hang ha polaka ea nakoana e se e le teng, lintho tse hoamisang mali li feta ka mokhoa o rarahaneng oa ketane ho ntša fibrin, protheine e thata, e khoele. Fibrin e itlama kahare le ho potoloha lesela le bonolo ho fihlela e e-ba lesela le thata le sa qhibiliheng la fibrin. Lera lena le lecha le koala methapo ea mali e robehileng, 'me le baka sekoaelo se sireletsang bakeng sa kholo e ncha ea lisele.

4. Pholiso ea maqeba le tšenyo ea polaka ea fibrin

Kamora matsatsi a 'maloa, lesela la fibrin le qala ho honyela, le hula likarolo tsa leqeba ho thusa lisele tse ncha ho hola holim'a leqeba. Ha lisele li ntse li ahoa bocha, lesela la fibrin lea qhibiliha ebe lea monyela.

Haeba factor VII e sa sebetse hantle, kapa e le nyane haholo, lesela le matla la fibrin le ke ke la theha hantle.

Ke eng e bakang khaello ea factor VII?

Khaello ea factor VII e kanna ea futsetsoa kapa ea fumanoa. Mofuta o futsitsoeng ha o fumanehe hangata. Ho tlalehiloe linyeoe tse ka tlase ho 200 tse tlalehiloeng. Batsoali ba hao ka bobeli ba tlameha ho jara liphatsa tsa lefutso e le hore u amehe.

Ho haelloa ke ntlha ea VII, ka lehlakoreng le leng, ho etsahala kamora ho hlaha. E ka hlaha ka lebaka la meriana kapa mafu a sitisang ntlha ea hau ea VII. Lithethefatsi tse ka fokolisang kapa tsa fokotsa ts'ebetso ea VII li kenyelletsa:

• lithibela-mafu
• tšesaane ea mali, joalo ka warfarin
• lithethefatsi tse ling tsa mofetše, joalo ka kalafo ea interleukin-2
• Phekolo ea antithymocyte globulin e sebelisetsoang ho phekola khaello ea mali ea mali

Maloetse le maemo a bongaka a ka sitisang factor VII a kenyelletsa:

• lefu la sebete
• myeloma
• sepsis
• anemia ea mali
• khaello ea vithamine K

Matšoao a khaello ea factor VII ke afe?

Matšoao a fapana ho tloha bobeng ho ea bohlokong, ho latela maemo a hau a ts'ebetsong a VII. Matšoao a bonolo a ka kenyelletsa:

• matetetso le lisele tse bonolo tse tsoang mali
• nako e telele e tsoang mali ho tsoa maqeba kapa ho ntšoa meno
• ho tsoa madi manonyeletsong
• dinko tsa nko
• marenene a tsoang mali
• linako tse boima tsa ho ilela khoeli

Maemong a boima haholo, matšoao a ka kenyelletsa:

• ho senyeha ha lefufuru manonyellong a tsoang mananeong a tsoang mali
• ho tsoa mali ka maleng, mpeng, mesifa kapa hloohong
• ho tsoa mali haholo ka mora ho beleha

Ho haella ha factor VII ho fumanoa joang?

Tlhahlobo e ipapisitse le nalane ea hau ea bongaka, nalane efe kapa efe ea lelapa ea mathata a tsoang mali, le liteko tsa lab.

Liteko tsa Lab bakeng sa khaello ea factor VII li kenyelletsa:

• Lintlha tsa tlhahlobo li supa lintho tse haellang kapa tse sa sebetseng hantle
• factor VII assay ho lekanya hore na u na le factor VII e kae, le hore na e sebetsa hantle hakae
• prothrombin time (PT) ho lekanya tšebetso ea lintlha I, II, V, VII, le X
• nako e sa lekanyetsoang ea prothrombin (PTT) ho lekanya tšebetso ea lintlha tsa VIII, IX, XI, XII, le lintlha tsa von Willebrand
• liteko tsa inhibitor ho fumana hore na sesole sa hau sa 'mele se hlasela mabaka a hau a ho koala

Ho haella ha factor VII ho alafshoa joang?

Kalafo ea khaello ea factor VII e shebile ho:

• ho laola ho tsoa madi
• ho rarolla maemo a ipatileng
• kalafo ea boits'ireletso pele ho ts'ebetso ea opereishene kapa ea meno

Ho laola ho tsoa mali

Nakong ea likarolo tsa ho tsoa mali, o ka fuoa infusions ea lintho tse hohelang mali ho matlafatsa bokhoni ba hau ba ho koala. Lisebelisoa tsa ho koala tse sebelisoang khafetsa li kenyelletsa:

• prothrombin e rarahaneng ea batho
• cryoprecipitate
• plasma e ncha e hoammeng
• recombinant human factor VIIa (NovoSeven)

Kalafo ea maemo a ipatileng

Hang ha ho tsoa mali ho laoloa, maemo a ka fokolisang tlhahiso ea VII kapa ts'ebetso ea ona, joalo ka meriana kapa mafu, a tlameha ho rarolloa.

Kalafo ea boits'oaro pele ho ts'ebetso

Haeba u ntse u rera ho buuoa, ngaka ea hau e ka u fa lithethefatsi ho fokotsa menyetla ea ho tsoa mali haholo. Desmopressin nasal spray hangata e laeloa ho lokolla mabenkele ohle a fumanehang a factor VII pele ho ts'ebetso e nyane. Bakeng sa liopereishene tse tebileng haholo, ngaka ea hau e ka 'na ea u laela hore u tšoauoe ke ntho e etsang hore mali a khaotse.

Pono ea nako e telele ke efe?

Haeba u na le mofuta o fumanoeng oa khaello ea factor VII, mohlomong o bakoa ke meriana kapa boemo bo itseng. Pono ea hau ea nako e telele e ipapisitse le ho lokisa mathata a teng. Haeba u na le mofuta o boima haholo oa bofokoli ba factor VII, o tla hloka ho sebetsa haufi-ufi le ngaka ea hau le setsi sa heno sa haemophilia ho laola likotsi tsa ho tsoa mali.