Phekolo ea Hormone bakeng sa mofetše oa senya

Phekolo ea Hormone bakeng sa mofetše oa senya e sebelisa opereishene kapa lithethefatsi ho theola maemo a lihormone tsa banna tsa botona le botšehali 'meleng oa monna. Sena se thusa ho liehisa kholo ea mofetše oa senya.

Androgens ke lihormone tsa banna tsa thobalano. Testosterone ke mofuta o le mong o ka sehloohong oa androgen. Boholo ba testosterone bo entsoe ke maselese. Litšoelesa tsa adrenal le tsona li hlahisa chelete e nyane.

Androgens e etsa hore lisele tsa mofetše oa tšoelesa ea senya li hōle. Phekolo ea Hormone bakeng sa mofetše oa senya e theola sekhahla sa phello ea li-androgens 'meleng. E ka etsa sena ka:

• Ho emisa li-testicles ho etsa li-androgens ho sebelisa opereishene kapa meriana
• Ho thibela ts'ebetso ea li-androgens 'meleng
• Ho emisa 'mele ho etsa li-androgens

Kalafo ea Hormone ha e so sebelisoe bakeng sa batho ba nang le mofetše oa Stage II kapa Stage II.

E sebelisoa haholo bakeng sa:

• Kankere e tsoetseng pele e hasaneng ho feta tšoelesa ea senya
• Kankere e hlotsoe ho arabela ts'ebetsong kapa mahlaseling
• Kankere e iphetileng

E kanna ea sebelisoa hape:

• Pele ho sebelisoa mahlaseli kapa ho buuoa ho thusa ho fokotsa lihlahala
• Hammoho le kalafo ea radiation bakeng sa mofetše e kanna ea ipheta

Kalafo e atileng haholo ke ho noa lithethefatsi tse theolelang bongata ba li-androgens tse entsoeng ke makoko. Li bitsoa luteinizing hormone-releasing hormone (LH-RH) analogs (liente) le anti-androgens (matlapa a molomo). Lithethefatsi tsena li theola maemo a androgen joalo ka ha ho etsoa opereishene. Mofuta ona oa kalafo ka linako tse ling o bitsoa "castration ea lik'hemik'hale."

Banna ba fumanang kalafo ea bohloki ba androgen ba lokela ho etsa liteko tsa tlhahlobo le ngaka e fanang ka litlhare:

• Nakong ea likhoeli tse 3 ho isa ho tse 6 kamora ho qala kalafo
• Bonyane hanngoe ka selemo, ho lekola khatello ea mali le ho etsa liteko tsa tsoekere maling (tsoekere) le liteko tsa k'holeseterole
• Ho fumana liteko tsa mali tsa PSA ho lekola hore na kalafo e sebetsa hantle hakae

LH-RH analogs li fanoa e le thunya kapa e le khehlo e nyane e behiloeng tlasa letlalo. Li fuoa kae kapa kae ho tloha hang ka khoeli ho isa hang ka selemo. Lithethefatsi tsena li kenyelletsa:

• Leuprolide (Lupron, Eligard)
• Goserelin (Zoladex)
• Triptorelin (Trelstar)
• Histrelin (Vantas)

Moriana o mong, degarelix (Firmagon), ke mohanyetsi oa LH-RH. E fokotsa maemo a androgen kapele mme e na le litla-morao tse fokolang. E sebelisoa ho banna ba nang le mofetše o tsoetseng pele.

Lingaka tse ling li khothaletsa ho emisa le ho qala kalafo hape (kalafo e kenang). Mokhoa ona o bonahala o thusa ho fokotsa litlamorao tsa kalafo ea lihormone. Leha ho le joalo, ha ho hlake hore na kalafo ea nakoana e sebetsa joang le kalafo e tsoelang pele. Liphuputso tse ling li bonts'a hore kalafo e tsoelang pele e sebetsa haholo kapa kalafo ea nakoana e lokela ho sebelisoa feela bakeng sa mefuta e khethiloeng ea mofetše oa senya.

Ho buoa ho tlosa li-testicles (castration) ho emisa tlhahiso ea li-androgens tse ngata 'meleng. Sena se boetse se fokotsa kapa ho emisa mofetše oa tšoelesa ea senya. Le ha e sebetsa, banna ba bangata ha ba khethe khetho ena.

Lithethefatsi tse ling tse sebetsang ka ho thibela phello ea androgen liseleng tsa mofetše oa tšoelesa ea senya. Li bitsoa anti-androgens. Meriana ena e nooa e le lipilisi. Hangata li sebelisoa ha meriana ea ho theola maemo a androgen e se e sa sebetse hape.

Li-anti-androgens li kenyelletsa:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Androgens e ka hlahisoa libakeng tse ling tsa 'mele, joalo ka litšoelesa tsa adrenal. Lisele tse ling tsa mofetše oa senya li ka etsa li-androgens. Lithethefatsi tse tharo li thusa ho emisa 'mele ho etsa li-androgens tse tsoang liseleng tse ling ntle le li-testicles.

Meriana e 'meli, ketoconazole (Nizoral) le aminoglutethimide (Cytradren), e alafa maloetse a mang empa ka linako tse ling e sebelisoa ho alafa mofetše oa senya. Ea boraro, abiraterone (Zytiga) e phekola mofetše o tsoetseng pele oa senya o nametseng libakeng tse ling 'meleng.

Ha nako e ntse e ea, mofetše oa tšoelesa ea senya o hana ho amohela kalafo ea lihormone. Sena se bolela hore mofetše o hloka feela maemo a tlase a androgen ho hola. Ha sena se etsahala, litlhare tse ling kapa litlhare tse ling li ka eketsoa.

Androgens e na le litlamorao hohle 'meleng. Kahoo, kalafo e theolang lihormone tsena e ka baka litlamorao tse ngata tse fapaneng. Ha u ntse u noa meriana ena, ho ka etsahala hore u be le litla-morao.

Li kenyeletsa:

• Mathata a ho ts'oaroa le ho se thahaselle thobalano
• Lisosa tse nyonyehang le botona
• Ho chesa haholo
• Masapo a fokolang kapa a robehileng
• Mesifa e menyenyane le e fokolang
• Liphetoho mafura a mali, joalo ka cholesterol
• Liphetoho tsoekere ea mali
• Boima ba 'mele
• Feto-fetoha
• Mokhathala
• Khōlo ea lisele tsa matsoele, bonolo ba matsoele

Phekolo ea khaello ea Androgen e ka eketsa likotsi tsa lefu la tsoekere le lefu la pelo.

Ho etsa qeto ea kalafo ea li-hormone bakeng sa mofetše oa senya e ka ba qeto e rarahaneng ebile e thata. Mofuta oa kalafo o ka itšetleha ka:

• Kotsi ea hau ea kankere e khutla
• Kankere ea hau e tsoetse pele hakae
• Hore na mekhoa e meng ea kalafo e emisitse ho sebetsa
• Hore na mofetše o hasane

Ho bua le mofani oa hau ka likhetho tsa hau le melemo le likotsi tsa kalafo ka 'ngoe ho ka u thusa ho etsa qeto e molemohali bakeng sa hau.

Phekolo ea khaello ea Androgen; ADT; Phekolo ea khatello ea Androgen; Thibelo ea androgen e kopantsoeng; Orchiectomy - kankere ea senya; Castration - mofetše oa senya

• Anatomy ea banna ea ho ikatisa

Webosaete ea American Cancer Society. Phekolo ea Hormone bakeng sa mofetše oa senya. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. E ntlafalitsoe ka la 18 Tšitoe 2019. E fihlile ka la 24 Hlakubele 2020.

Webosaete ea National Cancer Institute. Phekolo ea Hormone bakeng sa mofetše oa senya. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. E ntlafalitsoe ka la 28 Hlakola 2019. E fihlile ka la 17 Tšitoe 2019.

Webosaete ea National Cancer Institute. Kalafo ea mofetše oa senya (PDQ) - mofuta oa litsebi tsa bophelo bo botle. www.cancer.gov/types/prostate/hp/prostate- kalafo-pdq. E ntlafalitsoe ka la 29 Pherekhong 2020. E fihlile ka la 24 Hlakubele 2020.

Webosaete ea National Comprehensive Cancer Network. Litaelo tsa NCCN tsa litloaelo tsa kliniki ho oncology (litataiso tsa NCCN): mofetše oa senya. Mofuta oa 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. E ntlafalitsoe ka la 16 Hlakubele 2020. E fihlile ka la 24 Hlakubele 2020.

Phekolo ea Eggener S. Hormonal bakeng sa mofetše oa senya. Ka: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, bahlophisi. Urology ea Campbell-Walsh. 12th ed. Philadelphia, PA: Elsevier; 2021: khaolo ea 161.

• Kankere ea Prostate