Sengoli: Gregory Harris
Letsatsi La Creation: 8 April 2021
Ntlafatsa Letsatsi: 17 November 2024
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Multiple system system atrophy - mofuta oa parkinsonia - Moriana
Multiple system system atrophy - mofuta oa parkinsonia - Moriana

Multiple system system atrophy- parkinsonia mofuta (MSA-P) ke boemo bo sa tloaelehang bo bakang matšoao a ts'oanang le lefu la Parkinson. Leha ho le joalo, batho ba nang le MSA-P ba na le tšenyo e atileng haholo karolong ea sistimi ea methapo e laolang mesebetsi ea bohlokoa joalo ka lebelo la pelo, khatello ea mali le ho fufuleloa.

Karolo e 'ngoe ea MSA ke MSA-cerebellar. E ama haholo-holo libaka tse tebileng bokong, ka holim'a mokokotlo oa mokokotlo.

Lebaka la MSA-P ha le tsejoe. Libaka tse amehileng tsa boko lia kopana le libaka tse anngoeng ke lefu la Parkinson, tse nang le matšoao a tšoanang. Ka lebaka lena, karoloana ena ea MSA e bitsoa parkinsonian.

MSA-P hangata e fumanoa ho banna ba baholo ho feta 60.

MSA e senya tsamaiso ea methapo. Lefu lena le atisa ho tsoela pele ka potlako. Hoo e ka bang halofo ea batho ba nang le MSA-P ba lahlile boholo ba litsebo tsa bona tsa motlakase nakong ea lilemo tse 5 ho tloha ha lefu lena le qala.

Matšoao a ka kenyelletsa:

  • Litšisinyeho
  • Mathata a motsamao, joalo ka ho lieha, ho lahleheloa ke botsitso, ho thekesela ha u tsamaea
  • Ho oa khafetsa
  • Ho opeloa ke mesifa le bohloko (myalgia), le ho satalla
  • Liphetoho tsa sefahleho, joalo ka ponahalo e kang ea sefahleho sefahlehong le ho qamaka
  • Ho thata ho hlafuna kapa ho metsa (nako le nako), ho se khone ho koala molomo
  • Ho sitisoa mekhoa ea ho robala (hangata nakong ea ho sisinyeha ha mahlo ka potlako [REM] ho robala bosiu haholo)
  • Ho tsekela kapa ho akheha ha o ema kapa ka mora ho ema o tsitsitse
  • Mathata a ho emisa
  • Ho lahleheloa ke taolo holim'a mala kapa senya
  • Mathata ka tšebetso e hlokang motsamao o monyane (tahlehelo ea tsebo e ntle ea makoloi), joalo ka ho ngola ho nyane ebile ho le thata ho a bala
  • Ho fufuleloa karolong efe kapa efe ya mmele
  • Fokotseha tšebetsong ea kelello
  • Ho nyekeloa le mathata a ho senya lijo
  • Mathata a boemo ba mmele, joalo ka ho hloka botsitso, ho inama, kapa ho thella
  • Pono ea fetoha, ho fokotseha kapa ho fifala
  • Liphetoho tsa lentsoe le puo

Matšoao a mang a ka hlahang ka lefu lena:


  • Pherekano
  • Dementia ea kelello
  • Ho tepella maikutlo
  • Mathata a ho hema a amanang le boroko, ho kenyelletsa ho koaleha moea ka nakoana borokong kapa ho koaleha moea o lebisang molumo o thata o sisinyehang

Mofani oa hao oa tlhokomelo ea bophelo o tla u hlahloba, 'me au hlahlobe mahlo, methapo le mesifa.

Khatello ea mali ea hau e tla nkoa ha u ntse u robetse u eme.

Ha ho na liteko tse ikhethang tse netefatsang lefu lena. Ngaka e sebetsanang le sistimi ea methapo (neurologist) e ka etsa hore lefu lena le hlahlojoe ho latela:

  • Nalane ea matšoao
  • Liphetho tsa tlhahlobo ea 'mele
  • Ho busa lisosa tse ling tsa matšoao

Ho lekoa ho thusa ho netefatsa hore na lefu lena le fumanoa joang ho ka kenyelletsa:

  • MRI ea hlooho
  • Maemo a plasma norepinephrine
  • Ho hlahlojoa moroto bakeng sa lihlahisoa tsa ho senyeha ha norepinephrine (catecholamines ea moroto)

Ha ho na pheko bakeng sa MSA-P. Ha ho na mokhoa o tsebahalang oa ho thibela lefu lena ho mpefala. Morero oa kalafo ke ho laola matšoao.


Meriana ea Dopaminergic, e kang levodopa le carbidopa, e ka sebelisoa ho fokotsa ho thothomela ha nakoana kapa ka bonolo.

Empa, bakeng sa batho ba bangata ba nang le MSA-P, meriana ena ha e sebetse hantle.

Meriana e ka sebelisoa ho alafa khatello e tlase ea mali.

Mochine oa pacemaker o etselitsoeng ho susumetsa pelo hore e otle ka lebelo le potlakileng (ka lebelo ho feta likotlo tse 100 ka motsotso) o ka eketsa khatello ea mali ho batho ba bang.

Ho sokela ho ka phekoloa ka lijo tse nang le fiber e ngata le litlolo tsa ho hlatsoetsa. Ho na le meriana ea ho alafa mathata a ho tsoha.

Lintlha tse ling le tšehetso bakeng sa batho ba nang le MSA-P le malapa a bona li ka fumanoa ho:

  • Mokhatlo oa Naha oa Mathata a Rare - rarediseases.org/rare-diseases/multiple-system-atrophy
  • Mokhatlo oa MSA - www.multiplesystematrophy.org/msa-resource/

Sephetho sa MSA ha se hantle. Ho lahleheloa ke mesebetsi ea kelello le ea 'mele butle-butle ho mpefala. Ho ka etsahala hore lefu la pele. Batho ba phela lilemo tse 7 ho isa ho tse 9 kamora ho fumanoa.

Bitsa mofani oa hau haeba u ba le matšoao a lefu lena.


Bitsa mofani oa hau haeba u fumanoe u e-na le MSA mme matšoao a hau a khutla kapa a mpefala. Letsetsa hape haeba matšoao a macha a hlaha, ho kenyeletsoa litlamorao tse ka bang teng tsa meriana, joalo ka:

  • Liphetoho tlhokomelong / boits'oarong / maikutlo
  • Boitšoaro ba bolotsana
  • Botsoa
  • Litlelase
  • Mekhatlo ea boithatelo
  • Ho lahleheloa ke ts'ebetso ea kelello
  • Ho nyekeloa kapa ho hlatsa
  • Pherekano e matla kapa ho ferekana maikutlo

Haeba u na le setho sa lelapa se nang le MSA 'me boemo ba bona bo theoha hoo u sitoang ho hlokomela motho eo lapeng, batla boeletsi ho mofani oa setho sa lelapa la hau.

Shy-Drager lefu; Hypotension ea methapo ea pelo; Shy-McGee-Drager lefu; Parkinson hammoho le lefu; MSA-P; MSA-C

  • Sisteme ea methapo e bohareng le methapo ea methapo

Fanciulli A, Wenning GK. Multiprime-system atrophy. N Engl J Med. 2015; 372 (3): 249-263. PMID: 25587949 pubmed.ncbi.nlm.nih.gov/25587949/.

Lefu la Jankovic J. Parkinson le mathata a mang a motsamao. Ka: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, bahlophisi. Neurology ea Bradley ho Tloaelo ea Bongaka. La 7th. Philadelphia, PA: Elsevier; 2016: khaolo ea 96.

Romero-Ortuno R, Wilson KJ, Hampton JL. Mathata a tsamaiso ea methapo e ikemetseng. Ka: Tlatsa HM, Rockwood K, Young J, eds. Brocklehurst’s Textbook of Geriatric Medicine le Gerontology. La 8th. Philadelphia, PA: Elsevier; 2017: khaolo ea 63.

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