Cerebral amyloid angiopathy

Cerebral amyloid angiopathy (CAA) ke boemo boo liprotheine tse bitsoang amyloid li hahang maboteng a methapo bokong. CAA e eketsa kotsi ea stroke e bakoang ke ho tsoa mali le 'dementia'.

Batho ba nang le CAA ba na le liprotheine tsa amyloid maboteng a methapo ea mali bokong. Protheine hangata ha e bolokoe kae kapa kae 'meleng.

Lebaka le ka sehloohong la kotsi ke ho eketseha ha lilemo. CAA e bonoa hangata ho batho ba baholo ho feta lilemo tse 55. Ka linako tse ling, e fetisetsoa malapeng.

CAA e ka baka tšollo ea mali bokong. Ho tsoa mali hangata ho hlaha likarolong tse kantle tsa boko, tse bitsoang cortex, eseng libakeng tse tebileng. Matšoao a hlaha hobane ho tsoa mali bokong ho senya lisele tsa boko. Batho ba bang ba ba le mathata a ho hopola butle-butle. Ha CT scan e etsoa, ​​ho na le matšoao a hore ba kile ba tsoa mali bokong hoo e kanna eaba ha ba elelloe.

Haeba ho tsoa mali a mangata, matšoao a hanghang a hlaha mme a tšoana le stroke. Matšoao ana a kenyelletsa:

• Ho otsela
• Ho tšoaroa ke hlooho (hangata karolong e itseng ea hlooho)
• Liphetoho tsa tsamaiso ea methapo e ka qalang ka tšohanyetso, ho kenyelletsa pherekano, pherekano, pono e habeli, pono e fokotsehileng, liphetoho tsa maikutlo, mathata a puo, bofokoli kapa ho holofala
• Ho oa
• Stupor kapa coma (ka seoelo)
• Ho hlatsa

Haeba ho tsoa mali ho se matla kapa ho atile, matšoao a ka kenyelletsa:

• Likhaolo tsa pherekano
• Ho opeloa ke hlooho ho tlang le ho feta
• Ho lahleheloa ke ts'ebetso ea kelello ('dementia')
• Bofokoli kapa maikutlo a sa tloaelehang a tlang le ho feta, mme a kenyelletsa libaka tse nyane
• Ho oa

CAA e thata ho e fumana ntle le sampole ea lisele tsa boko. Hangata hona ho etsoa kamora lefu kapa ha biopsy ea methapo ea mali ea boko e etsoa.

Tlhahlobo ea 'mele e ka ba ntho e tloaelehileng haeba ho tsoa mali ho le nyane. Ho kanna ha ba le liphetoho tse ling tsa ts'ebetso ea boko. Ho bohlokoa hore ngaka e botse lipotso tse qaqileng mabapi le matšoao le nalane ea bongaka. Matšoao le sephetho sa tlhahlobo ea 'mele le liteko life kapa life tsa ho nka litšoantšo li ka etsa hore ngaka e belaele CAA.

Ho nahana ka liteko tsa hlooho tse ka etsoang ho kenyelletsa:

• CT scan kapa MRI scan ho hlahloba ho tsoa ha mali bokong
• MRA e hlahloba ho hlahloba mali a maholo le ho tlosa lisosa tse ling tsa ho tsoa mali
• PET scan ho hlahloba li-amyloid depositi bokong

Ha ho na kalafo e tsebahalang e sebetsang. Morero oa kalafo ke ho imolla matšoao. Maemong a mang, tlhabollo e ea hlokahala molemong oa bofokoli kapa bohlasoa. Sena se ka kenyelletsa kalafo ea 'mele, mosebetsi, kapa puo.

Ka linako tse ling, ho sebelisoa meriana e thusang ho ntlafatsa mohopolo, joalo ka ea lefu la Alzheimer.

Ho oa, le hona ho bitsoang boloi ba amyloid, ho ka alafshoa ka litlhare tse loantšang sethoathoa.

Boloetse bona bo mpefala butle-butle.

Mathata a CAA a ka kenyelletsa:

• Dementia ea kelello
• Hydrocephalus (ka seoelo)
• Ho oa
• Likarolo tse phetoang tsa ho tsoa mali bokong

E-ea kamoreng ea maemo a tšohanyetso kapa u letsetse nomoro ea lehae ea maemo a tšohanyetso (joalo ka 911) haeba u ka felloa ke matla ka tšohanyetso, ha u sa utloe maikutlo kapa u sa khone ho bua.

Amyloidosis - bokong; CAA; Angiopathy e kopaneng

• Amyloidosis ea menoana
• Metsing ea boko

Charidimou A, Boulouis G, Gurol ME, le al. Likhopolo tse hlahang ka nakoana ho angiopathy ea boko. Boko. 2017; 140 (7): 1829-1850. PMID: 28334869 phatlalatsoa.ncbi.nlm.nih.gov/28334869/.

Greenberg SM, Charidimou A. Ho hlahlojoa ha angiopathy ea cerebral amyloid: phetoho ea litekanyetso tsa Boston. Leqeba. 2018; 49 (2): 491-497. PMID: 29335334 pubmed.ncbi.nlm.nih.gov/29335334/.

Kase CS, Shoamanesh A. Tšollo ea mali ea Intracerebral. Ka: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, bahlophisi. Neurology ea Bradley ho Tloaelo ea Bongaka. La 7th. Philadelphia, PA: Elsevier; 2016: khaolo ea 66.