Tsoelo-pele ea multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) ke tšoaetso e sa tloaelehang e senyang thepa (myelin) e koahelang le ho sireletsa methapo ea kutlo e tšoeu ea boko.

Lefu la John Cunningham, kapa JC virus (JCV) le baka PML. JC virus e boetse e tsejoa e le polyomavirus ea motho 2. Ha a le lilemo li 10, batho ba bangata ba tšoaelitsoe ke vaerase ena leha e sa bake matšoao. Empa batho ba nang le boits'ireletso ba mmele bo fokolang ba kotsing ea ho ba le PML. Lisosa tsa sesole sa 'mele se fokolang li kenyelletsa:

• HIV / AIDS (sesosa se sa tloaelehang sa PML ha joale ka lebaka la taolo e betere ea HIV / AIDS).
• Meriana e meng e hatellang sesole sa 'mele e bitsoang li-antibodies tsa monoclonal. Meriana e joalo e ka sebelisoa ho thibela ho khesoa ha setho sa setho kapa ho phekola multiple sclerosis, ramatiki ea ramatiki le mathata a mang a autoimmune, le maemo a amanang le ona.
• Kankere, joalo ka kankere ea mali le Hodgkin lymphoma.

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Tahlehelo ea tšebelisano, bohlasoa
• Tahlehelo ea bokhoni ba puo (aphasia)
• Ho lahleheloa ke mohopolo
• Mathata a pono
• Bofokoli ba maoto le matsoho bo ntseng bo mpefala
• Botho boa fetoha

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao.

Liteko li ka kenyelletsa:

• Biopsy ea boko (maemong a sa tloaelehang)
• Teko ea "cerebrospinal fluid" ea "JCV"
• Tlhatlhobo ea CT ea boko
• Electroencephalogram (EEG)
• MRI ea boko

Ho batho ba nang le HIV / AIDS, kalafo ea ho matlafatsa sesole sa 'mele e ka lebisa ho hlaphoheloeng matšoao a PML. Ha ho liphekolo tse ling tse ipakileng li sebetsa bakeng sa PML.

PML ke boemo bo sokelang bophelo. Ho latela hore na tšoaetso e matla hakae, ho fihlela halofo ea batho ba fumanoeng ba e-na le PML ba shoa likhoeling tse 'maloa tsa pele.

PML; Lefu la John Cunningham; JCV; Polyomavirus ea batho 2; Lefu la JC

• Botala le bosoeu taba ea boko
• Leukoencephalopathy

Berger JR, Nath A. Cytomegalovirus, vaerase ea Epstein-Barr, le tšoaetso ea vaerase e liehang tsamaisong ea methapo e bohareng. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 26th. Philadelphia, PA: Elsevier; 2020: khaolo ea 346.

Tan CS, Koralnik IJ. JC, BK, le li-virus tse ling tsa polyoma: leukoencephalopathy e ntseng e tsoela pele (PML). Ka: Bennett JE, Dolin R, Blaser MJ, bahlophisi. Mandell, Douglas, le Bennett's Principles and Practice of Infectious Diseases. La 9th. Philadelphia, PA: Elsevier; 2020: khaolo ea 144.