Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis ke lefu la liphio le kenyelletsang ho ruruha le liphetoho liseleng tsa liphio. E ka lebisa ho hloleha ha liphio.

Glomerulonephritis ke ho ruruha ha glomeruli. Glomeruli ea liphio e thusa ho sefa litšila le maro a tsoang maling ho etsa moroto.

Membranoproliferative glomerulonephritis (MPGN) ke mofuta oa glomerulonephritis o bakoang ke karabelo e sa tloaelehang ea boits'ireletso ba mmele. Mehloli ea li-antibodies e ahella karolong e itseng ea liphio e bitsoang leqhoa le ka tlas'a lefatše le benyang. Lera lena le thusa ho sefa litšila le maro a mang a tsoang maling.

Tšenyo ea lera lena e ama bokhoni ba liphio ba ho etsa moroto ka mokhoa o tloaelehileng. E kanna ea lumella mali le protheine ho lutla ka har'a moroto. Haeba liprotheine tse lekaneng li dutla ka morong, mokelikeli o ka tsoa methapong ea mali ka har'a lisele tsa 'mele, e lebisang ho ruruheng. Lihlahisoa tsa naetrojene le tsona li ka bokellana maling (azotemia).

Mefuta e 2 ea lefu lena ke MPGN I le MPGN II.

Batho ba bangata ba nang le lefu lena ba na le mofuta oa I. MPGN II ha e atisehe haholo. E boetse e tloaetse ho mpefala kapele ho feta MPGN I.

Lisosa tsa MPGN li ka kenyelletsa:

• Maloetse a ikemetseng (systemic lupus erythematosus, scleroderma, Sjögren syndrome, sarcoidosis)
• Kankere (leukemia, lymphoma)
• Matšoao (hepatitis B, hepatitis C, endocarditis, malaria)

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Mali ka morong
• Liphetoho maemong a kelello joalo ka ho fokotsa ho falimeha kapa ho fokotsa ho tsepamisa mohopolo
• Moroto o koahetsoeng ke maru
• Motsoako o lefifi (mosi, cola, kapa 'mala oa tee)
• Fokotsa molumo oa moroto
• Ho ruruha hoa karolo efe kapa efe ya mmele

Mofani oa tlhokomelo ea bophelo o tla u hlahloba le ho botsa matšoao a hau. Mofani oa hau a ka fumana hore o na le matšoao a mokelikeli o mongata haholo 'meleng, joalo ka:

• Ho ruruha, hangata maotong
• Melumo e sa tloaelehang ha u mametse pelo le matšoafo ka stethoscope
• U kanna oa ba le khatello e phahameng ea mali

Liteko tse latelang li thusa ho netefatsa ts'oaetso:

• BUN le tlhahlobo ea mali ea creatinine
• Mekhahlelo ea tlatsetso ea mali
• Ho hlahloba urinal
• Protheine ea moroto
• Liphio biopsy (ho netefatsa membranoproliferative GN I kapa II)

Kalafo e ipapisitse le matšoao. Morero oa kalafo ke ho fokotsa matšoao, ho thibela mathata le ho liehisa kholo ea lefu lena.

U kanna ua hloka phetoho lijong. Sena se ka kenyelletsa ho fokotsa sodium, maro, kapa protheine ho thusa ho laola khatello e phahameng ea mali, ho ruruha le bongata ba litšila maling.

Meriana e ka laeloang e kenyelletsa:

• Meriana ea khatello ea mali
• Dipyridamole, ka aspirin kapa ntle le eona
• Li-diuretics
• Meriana e hatellang sesole sa 'mele, joalo ka cyclophosphamide
• Li-steroid

Kalafo e sebetsa haholo ho bana ho feta ho batho ba baholo. Dialysis kapa ho kenya liphio ho ka qetella ho hlokahala ho sebetsana le ho hloleha ha liphio.

Boloetse bona hangata bo mpefala butle mme qetellong bo baka ho hloleha ha liphio ho sa foleng.

Halofo ea batho ba nang le boemo bona ba holisoa ke liphio nako e telele (e sa foleng) nakong ea lilemo tse 10. Sena se ka etsahala ho ba nang le liprotheine tse phahameng morong oa bona.

Mathata a ka hlahisoang ke lefu lena a kenyelletsa:

• Lefu la acute nephritic
• Ho hloleha ho matla ha renal
• Lefu le sa foleng la liphio

Bitsa kopano le mofani oa hau haeba:

• O na le matšoao a boemo bona
• Matšoao a hau a mpefala kapa ha a fele
• U hlahisa matšoao a macha, ho kenyeletsoa le phokotso ea tlhahiso ea moroto

Ho thibela tšoaetso e kang hepatitis kapa ho laola mafu a kang lupus ho ka thusa ho thibela MPGN.

Membranoproliferative GN I; Membranoproliferative GN II; Mesangiocapillary glomerulonephritis; Glomerulonephritis ea memembranoproliferative; Lobular GN; Glomerulonephritis - lera la mokokotlo; Mofuta oa MPGN I; Mofuta oa II oa MPGN

• Anatomy ea liphio

Roberts ISD. Maloetse a liphio. Ka: Cross SS, e hlophisitsoeng. Underwood's Pathology: Tsela ea Tleliniking. La 7th. Philadelphia, PA: Elsevier; 2019: khaolo ea 21.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Lefu la mantlha la glomerular. Ka: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, li-eds. Brenner le Rector ea Liphio. 11th ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 31.

Sethi S, De Vriese AS, Fervenza FC. Membranoproliferative glomerulonephritis le cryoglobulinemic glomerulonephritis. Ho: Feehally J, Floege J, Tonelli M, Johnson RJ, bangoli. Kakaretso ea Nephrology ea Kliniki. La 6th. Philadelphia, PA: Elsevier; 2019: khaolo ea 21.