Lupus erythematosus e bakoang ke lithethefatsi

Lupus erythematosus e bakoang ke lithethefatsi ke boloetse bo ikemetseng bo bakoang ke karabelo ea moriana.

Lupus erythematosus e bakoang ke lithethefatsi e tšoana empa ha e tšoane le systemic lupus erythematosus (SLE). Ke boloetse bo ikemetseng. Sena se bolela hore 'mele oa hau o hlasela lisele tse phetseng hantle ka phoso. E bakoa ke karabelo moriana. Maemo a amanang le ona ke li-lupus le li-ANCA vasculitis tse bakoang ke lithethefatsi.

Meriana e tloaelehileng haholo e tsejoang ho baka lupus erythematosus e bakoang ke lithethefatsi ke:

• Isoniazid
• Hydralazine
• Procainamide
• Tumor-necrosis factor (TNF) alpha inhibitors (joalo ka etanercept, infliximab le adalimumab)
• Minocycline
• Quinidine

Lithethefatsi tse ling tse sa tloaelehang le tsona li ka baka boemo. Tsena li ka kenyelletsa:

• Meriana e thibelang ho inkela
• Capoten
• Chlorpromazine
• Methyldopa
• Sulfasalazine
• Levamisole, hangata e le se silafatsang k'hok'heine

Lithethefatsi tsa mofets'e tsa mofets'e tse kang pembrolizumab le tsona li ka baka likarabo tse fapaneng tsa boits'ireletso ho kenyelletsa le lupus e bakoang ke lithethefatsi.

Matšoao a lupus e bakoang ke lithethefatsi a atisa ho hlaha kamora ho noa moriana bonyane likhoeli tse 3 ho isa ho tse 6.

Matšoao a ka kenyelletsa:

• Feberu
• Boikutlo bo tloaelehileng ba ho kula (malaise)
• Bohloko bo kopaneng
• Ho ruruha ho kopaneng
• Ho felloa ke takatso ea lijo
• Bohloko ba sefuba sa Pleuritic
• Ho phatloha ha letlalo libakeng tse chabetsoeng ke letsatsi

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a mamele sefuba sa hau ka stethoscope. Mofani oa thepa a ka utloa molumo o bitsoang `` rub friction '' ea pelo kapa mokokotlo oa likhohlano.

Tlhahlobo ea letlalo e bonts'a lekhopho.

Manonyeletso a ka ruruha a ba bonolo.

Liteko tse ka etsoang li kenyelletsa:

• Lisireletsi tsa antihistone
• Phanele ea Antinuclear antibody (ANA)
• Phanele ea Antineutrophil cytoplasmic antibody (ANCA)
  
• Palo e felletseng ea mali (CBC) ka phapang
• Karolo e felletseng ea k'hemistri
• Ho hlahloba urinal

X-ray ea sefuba e ka bonts'a matšoao a pleuritis kapa pericarditis (ho ruruha ho potoloha lera la matšoafo kapa pelo). ECG e kanna ea bontša hore pelo e amehile.

Boholo ba nako, matšoao a fela matsatsing a 'maloa ho isa ho libeke kamora ho emisa moriana o bakileng boemo boo.

Kalafo e ka kenyelletsa:

• Lithethefatsi tse seng khahlanong le ho ruruha (li-NSAID) ho phekola ramatiki le pleurisy
• Litlolo tsa Corticosteroid ho phekola makhopho a letlalo
• Lithethefatsi tse loantšang malaria (hydroxychloroquine) ho phekola matšoao a letlalo le ramatiki

Haeba boemo bona bo ama pelo ea hau, liphio kapa tsamaiso ea methapo, o ka fuoa litekanyetso tse phahameng tsa corticosteroids (prednisone, methylprednisolone) le li-suppressant tsa immune system (azathioprine kapa cyclophosphamide). Sena ke seoelo.

Ha lefu lena le se le sebetsa, o lokela ho apara liaparo tse sireletsang le likhalase tsa mahlo ho itšireletsa letsatsing le leholo.

Boholo ba nako, lupus erythematosus e bakoang ke lithethefatsi ha e matla joaloka SLE. Hangata matšoao a fela ka mor'a matsatsi a 'maloa ho isa ho libeke kamora ho emisa moriana oo u neng u o noa. Hangata, ho ruruha ha liphio (nephritis) ho ka hlaha ka lupus e bakoang ke lithethefatsi e bakoang ke TNF inhibitors kapa ka ANCA vasculitis ka lebaka la hydralazine kapa levamisole. Nephritis e ka hloka kalafo ka meriana ea prednisone le immunosuppressive.

Qoba ho noa moriana o bakileng karabelo nakong e tlang. Matšoao a kanna a khutla ha o etsa joalo.

Mathata a ka kenyelletsa:

• Tšoaetso
• Thrombocytopenia purpura - ho tsoa mali pela letlalo, ho bakoang ke palo e tlase ea liplatelete maling
• Phokolo ea mali ea hemolytic
• Myocarditis
• Pericarditis
• Nephritis

Bitsa mofani oa hau haeba:

• U hlahisa matšoao a macha ha u noa efe kapa efe ea meriana e thathamisitsoeng kaholimo.
• Matšoao a hau ha a fole kamora ho emisa ho noa moriana o bakileng boemo boo.

Shebella matšoao a karabelo haeba u noa lithethefatsi tse ka bakang bothata bona.

Lupus - e bakoang ke lithethefatsi

• Lupus, discoid - pono ea liso sefubeng
• Masole a mmele

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Dooley MA. Lupus e bakoang ke lithethefatsi. Ka: Tsokos GC, ed. Lupus Erythematosus e hlophisehileng. Cambridge, MA: Khatiso ea Boithuto ea Elsevier; 2016: khaolo ea 54.

Radhakrishnan J, Perazella MA. Lefu la glomerular le bakoang ke lithethefatsi: tlhokomelo ea hlokahala! Kliniki J Am Soc Nephrol. 2015; 10 (7): 1287-1290. PMID: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

Richardson BC. Lupus e bakoang ke lithethefatsi. Ho: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, bahlophisi. Rheumatology. La 7th. Philadelphia, PA: Elsevier; 2019: khaolo ea 141.

Rubin RL. Lupus e bakoang ke lithethefatsi. Setsebi Opin Drug Saf. 2015; 14 (3): 361-378. PMID: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

Vaglio A, PC ea Grayson, Fenaroli P, le al. Lupus e bakoang ke lithethefatsi: likhopolo tsa setso le tse ncha. Iketsetse Auto Rev. 2018; 17 (9): 912-918. PMID: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.