Felty lefu

Felty syndrome ke boloetse bo kenyeletsang ramatiki ea ramatiki, spleen e ruruhileng, ho fokotseha ha palo ea lisele tse tšoeu tsa mali le tšoaetso e phetoang. Ke ka seoelo.

Lebaka la Felty syndrome ha le tsejoe. E tloaelehile haholo ho batho ba nang le ramatiki ea mafu a mafura ka nako e telele. Batho ba nang le lefu lena ba kotsing ea tšoaetso hobane ba na le palo e tlase ea lisele tse tšoeu tsa mali.

Matšoao a kenyelletsa:

• Boikutlo bo tloaelehileng ba ho se utloise bohloko (malaise)
• Mokhathala
• Bofokoli ba leoto kapa letsoho
• Ho felloa ke takatso ea lijo
• Ho theola boima ba 'mele ka boomo
• Liso tsa letlalo
• Ho ruruha ho kopaneng, ho satalla, bohloko le ho holofala
• Matšoao a tloaelehileng
• Leihlo le khubelu ka ho chesa kapa ho tsoa

Tlhahlobo ea 'mele e tla bontša:

• Ho ruruha spleen
• Manonyeletso a bonts'ang matšoao a RA
• Mohlomong ho ruruha sebete le li-lymph node

Palo e felletseng ea mali (CBC) e nang le phapano e tla bonts'a palo e tlase ea lisele tse tšoeu tsa mali tse bitsoang neutrophils. Hoo e batlang e le batho bohle ba nang le lefu la Felty ba na le teko e nepahetseng ea lefu la ramatiki.

Ultrasound ea mpeng e kanna ea tiisa spleen e ruruhileng.

Maemong a mangata, batho ba nang le lefu lena ha ba fumane kalafo e khothalletsoang bakeng sa RA. Ba kanna ba hloka meriana e meng ho hatella sesole sa bona sa 'mele le ho fokotsa ts'ebetso ea RA ea bona.

Methotrexate e ka ntlafatsa palo e tlase ea neutrophil. Rituximab ea lithethefatsi e atlehile ho batho ba sa arabeleng methotrexate.

Granulocyte-colony factor stimulating factor (G-CSF) e ka phahamisa palo ea neutrophil.

Batho ba bang ba rua molemo ka ho tlosoa ha spleen (splenectomy).

Ntle le kalafo, tšoaetso e ka tsoelapele ho hlaha.

RA e kanna ea mpefala.

Ho phekola RA, leha ho le joalo, ho lokela ho ntlafatsa Felty syndrome.

U kanna oa ba le tšoaetso e lulang e khutla.

Batho ba bang ba nang le lefu la Felty ba na le li-lymphocyte tse kholo tse nang le granular, tse bitsoang LGL leukemia. Sena se tla phekoloa ka methotrexate maemong a mangata.

Bitsa mofani oa tlhokomelo ea bophelo haeba u ba le matšoao a lefu lena.

Kalafo e potlakileng ea RA le meriana e khothalletsoang hajoale e fokotsa menyetla ea ho ba le lefu la Felty.

Seropositive ramatiki ea ramatiki (RA); Lefu la Felty

• Masole a mmele

Bellistri JP, Muscarella P. Splenectomy bakeng sa mathata a hematologic. Ka: Cameron JL, Cameron AM, bahlophisi. Phekolo ea Hajoale ea Ts'ebetso. 12th ed. Philadelphia, PA: Elsevier; Ka 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Likarolo tsa bongaka tsa ramatiki ea ramatiki. Ka: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, bahlophisi. Kelley le Firestein's Bookbook ea Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: khaolo ea 70.

Gazitt T, Loughran TP Jr. neutropenia e sa foleng ho LGL leukemia le ramatiki ea ramatiki. Hematology Am Soc Hematol Lenaneo la Thuto. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Likarolo tse ikhethang tsa ramatiki ea ramatiki. Ho: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, bahlophisi. Rheumatology. La 7th. Philadelphia, PA: Elsevier; 2019: khaolo ea 95.

Savola P, Brück O, Olson T, le al. Somatic STAT3 liphetoho liphatseng tsa lefutso Felty syndrome: moelelo oa pathogenesis e tloaelehileng e nang le leukemia e kholo ea lymphocyte. Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Motsoali: Wang CR, Chiu YC, Chen YC. Phekolo e atlehileng ea neutropenia e sa tsitsang ho Felty's syndrome e nang le rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.