Bokheleke

Acromegaly ke boemo boo ho nang le hormone ea kholo e ngata haholo 'meleng.

Acromegaly ke boemo bo sa tloaelehang. E bakoa ha tšoelesa ea pituitary e etsa kholo ea kholo ea li-hormone. Tšoelesa ea pituitary ke tšoelesa e nyane ea endocrine e khomaretsoeng tlase bokong. E laola, e etsa, ebile e ntša lihormone tse 'maloa ho kenyeletsoa kholo ea lihormone.

Hangata hlahala e se nang kankere (e nang le bothata) ea tšoelesa ea pituitary e ntša hormone ea kholo e ngata haholo. Maemong a sa tloaelehang, lihlahala tsa pituitary li ka futsetsoa.

Ho bana, GH e ngata haholo e baka gigantism ho fapana le acromegaly.

Matšoao a acromegaly a ka kenyelletsa tse latelang:

• Monko oa 'mele
• Mali ka setuloaneng
• Lefu la Carpal tunnel
• Ho fokotsa matla a mesifa (bofokoli)
• Ho fokotsa pono ea ponahalo
• Mokhathala o bonolo
• Bophahamo bo fetelletseng (ha tlhahiso e fetelletseng ea GH e qala bongoaneng)
• Ho fufuleloa ho feteletseng
• Ho opeloa ke hlooho
• Ho eketsa pelo, ho ka bakang ho akheha
• Ho thothofala
• Bohloko ba mohlahare
• Mahlaba a kopaneng, motsamao o lekanyelitsoeng oa lenonyello, ho ruruha ha libaka tsa masapo ho potoloha lenonyeletso
• Masapo a maholo a sefahleho, mohlahare o moholo le leleme, meno a arohaneng haholo
• Maoto a maholo (fetola boholo ba lieta), matsoho a maholo (phetoho ea lesale kapa boholo ba tlelafo)
• Litšoelesa tse kholo letlalong (litšoelesa tse sebaceous) tse bakang letlalo le mafura, botenya ba letlalo, li-tag tsa letlalo (kholo)
• Ho koaleha moea ka nakoana borokong
• Ho atolosa menoana kapa menoana, ka ho ruruha, bofubelu le bohloko

Matšoao a mang a ka hlahang ka lefu lena:

• Li-polyps tsa Colon
• Khōlo e feteletseng ea moriri ho basali (hirsutism)
• Khatello ea mali e phahameng
• Mofuta oa 2 oa lefu la tsoekere
• Ho atolosoa ha qoqotho
• Boima ba 'mele

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao a hau.

Liteko tse latelang li ka laeloa ho netefatsa tlhahlobo ea acromegaly le ho lekola mathata:

• Tsoekere ea mali
• Hormone ea kholo le kholo ea khatello ea kholo
• Khōlo ea 1 e tšoanang le insulin (IGF-1)
• Prolactin
• X-ray ea mokokotlo
• MRI ea boko, ho kenyelletsa le tšoelesa ea pituitary
• Echocardiogram
• Colonoscopy
• Ho ithuta ho robala

Liteko tse ling li ka laeloa ho lekola hore na karolo e setseng ea pituitary e sebetsa ka mokhoa o tloaelehileng.

Ho buoa ho tlosa hlahala ea pituitary e bakang boemo bona hangata ho lokisa GH e sa tloaelehang. Ka linako tse ling, hlahala e kholo haholo hore e ka tlosoa ka botlalo mme acromegaly ha e phekoloe. Maemong ana, meriana le radiation (radiotherapy) li ka sebelisoa ho phekola acromegaly.

Batho ba bang ba nang le lihlahala tse rarahaneng haholo ho li tlosa ka ho buuoa ba phekoloa ka meriana ho fapana le ho buuoa. Meriana ena e ka thibela tlhahiso ea GH ho tsoa tšoelesa ea pituitary kapa ea thibela ts'ebetso ea GH likarolong tse ling tsa 'mele.

Kamora kalafo, o tla hloka ho bona mofani oa hau khafetsa ho etsa bonnete ba hore tšoelesa ea pituitary e sebetsa ka mokhoa o tloaelehileng le hore acromegaly ha e khutle. Litlhahlobo tsa selemo le selemo lia khothaletsoa.

Lisebelisoa tsena li ka fana ka tlhaiso-leseling e batsi ka acromegaly:

• Setsi sa Naha sa Lefu la Ts'oaetso le Mafu a Ts'oaetso le Pelo - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• Mokhatlo oa Naha oa Mathata a Rare - rarediseases.org/rare-diseases/acromegaly

Ho buuoa ka pituitary ho atleha ho batho ba bangata, ho latela boholo ba hlahala le boiphihlelo ba methapo ea kutlo e nang le lihlahala tsa pituitary.

Ntle le kalafo, matšoao a tla mpefala. Ho ka hlaha maemo a kang khatello e phahameng ea mali, lefu la tsoekere le lefu la pelo.

Bitsa mofani oa hau haeba:

• O na le matšoao a acromegaly
• Matšoao a hau ha a ntlafatse kalafo

Acromegaly e ke ke ea thibeloa. Kalafo ea kapele e ka thibela lefu lena ho mpefala le ho thusa ho qoba mathata.

Somatotroph adenoma; Hormone ea kholo ea kholo; Kholo ea ho boloka li-pituitary adenoma ea kholo; Pituitary giant (bongoaneng)

• Litšoelesa tsa endocrine

Katznelson L, Melao ER Jr, Melmed S, et al. Acromegaly: tataiso ea boits'oaro ba sechaba sa endocrine. J Kliniki ea Endocrinol Metab. 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Mathata a endocrine le lefu la pelo. Ka: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, bahlophisi. Lefu la pelo la Braunwald: Buka ea bongaka ea meriana ea pelo. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015: khaolo ea 81.

Melmed S. Acromegaly. Ka: Jameson JL, De Groot LJ, oa Kretser DM, et al, eds. Endocrinology: Batho ba baholo le bana. La 7th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 12.