Cholesterol - kalafo ea lithethefatsi

'Mele oa hau o hloka cholesterol hore e sebetse hantle. Empa k'holeseterole e eketsehileng e maling a hao e etsa hore u bokellane maboteng a ka hare a methapo ea hao ea mali. Moqapi ona o bitsoa plaque. E fokotsa methapo ea hau mme e ka fokotsa kapa ea emisa phallo ea mali. Sena se ka lebisa tlhaselong ea pelo, ho otloa ke pelo, le ho fokotsa methapo ea mali kae kapa kae 'meleng oa hau.

Ho nahanoa hore li-Statins ke meriana e molemohali eo u ka e sebelisang bakeng sa batho ba hlokang meriana ho theola k'holeseterole ea bona.

Hyperlipidemia - kalafo ea lithethefatsi; Ho thatafala ha methapo - statin

Lipolelo li fokotsa kotsi ea lefu la pelo, stroke le mathata a mang a amanang le ona. Ba etsa sena ka ho theola cholesterol ea hau ea LDL (bad).

Boholo ba nako o tla hloka ho noa moriana ona bophelo bohle ba hau. Maemong a mang, ho fetola tsela eo u phelang ka eona le ho theola boima ba 'mele ho ka u lumella ho emisa ho noa moriana ona.

Ho ba le LDL e tlase le k'holeseterole e felletseng ho fokotsa kotsi ea lefu la pelo. Empa ha se motho e mong le e mong ea hlokang ho nka li-statin ho theola k'holeseterole.

Mofani oa hao oa tlhokomelo ea bophelo o tla etsa qeto mabapi le kalafo ea hau ho latela:

• Kakaretso ea li-cholesterol tsa HDL (e ntle), le LDL (tse mpe)
• Lilemo tsa hau
• Nalane ea hau ea lefu la tsoekere, khatello e phahameng ea mali kapa lefu la pelo
• Mathata a mang a bophelo bo ka bakoang ke "cholesterol" e phahameng
• Hore na oa tsuba kapa che
• Kotsi ea lefu la pelo
• Morabe oa hau

U lokela ho nka liemahale haeba u le lilemo li 75 kapa tlase, 'me u na le nalane ea:

• Mathata a pelo ka lebaka la methapo e menyenyane e ka pelong
• Stroke kapa TIA (stroke se senyenyane)
• Aortic aneurysm (e nang le mothapo o moholo 'meleng oa hau)
• Ho khutsufatsa methapo maotong a hau

Haeba u le lilemo li fetang 75, mofani oa hau a ka fana ka tekanyetso e tlase ea statin. Sena se ka thusa ho fokotsa litlamorao tse ka bang teng.

U lokela ho nka li-statin haeba k'holeseterole ea hau ea LDL e le 190 mg / dL kapa e phahameng. U lokela hape ho nka li-statin haeba k'holeseterole ea hau ea LDL e lipakeng tsa 70 le 189 mg / dL le:

• U na le lefu la tsoekere 'me u pakeng tsa lilemo tse 40 le 75
• U na le lefu la tsoekere le kotsi e kholo ea lefu la pelo
• U na le kotsi e kholo ea lefu la pelo

Uena le mofani oa hau le kanna la batla ho nahana ka li-statins haeba LDL cholesterol ea hau e le 70 ho isa ho 189 mg / dL le:

• U na le lefu la tsoekere le kotsi e mahareng ea lefu la pelo
• U na le kotsi e mahareng ea lefu la pelo

Haeba u na le kotsi e kholo ea lefu la pelo mme k'holeseterole ea hau ea LDL e lula e phahame le kalafo ea li-statin, mofani oa hau a ka nahana ka lithethefatsi tsena ho kenyelletsa li-statin:

• Ezetimibe
• PCSK9 inhibitors, joalo ka alirocumab le evolocumab (Repatha)

Lingaka li ne li tloaetse ho ipehela sekhahla sa cholesterol ea hau ea LDL. Empa hona joale sepheo se fokotsa menyetla ea hau ea mathata a bakoang ke ho fokotsa methapo ea hau. Mofani oa hau a ka shebella li-cholesterol tsa hau. Empa tlhahlobo ea khafetsa ha e hlokahale hangata.

Uena le mofani oa hau le tla etsa qeto ea hore na u lokela ho nka statin efe. Haeba u na le mabaka a kotsi, u kanna ua hloka ho noa litekanyetso tse phahameng. kapa eketsa mefuta e meng ea lithethefatsi. Lintlha tseo mofani oa hau a tla li nahana ha a khetha kalafo ea hau li kenyelletsa:

• Kakaretso ea li-cholesterol tsa HDL le LDL pele ho kalafo
• Hore na o na le lefu la methapo ea mali (nalane ea angina kapa lefu la pelo), nalane ea stroke, kapa methapo e menyenyane maotong a hao
• Hore na o na le lefu la tsoekere
• Hore na oa tsuba kapa o na le khatello e phahameng ea mali

Litekanyetso tse phahameng li ka lebisa litlamorao ha nako e ntse e tsamaea. Kahoo mofani oa hau o tla nahana ka lilemo tsa hau le lisosa tsa kotsi bakeng sa litla-morao.

• Cholesterol
• Letlapa le hahang ka methapo

Mokhatlo oa Amerika oa lefu la tsoekere. Lefu la pelo le taolo ea likotsi: litekanyetso tsa kalafo ea lefu la tsoekere -2020. Tlhokomelo ea lefu la tsoekere. 2018; 43 (Tlatsetso ea 1): S111-S134. PMID: 31862753 e fetotsoe.ncbi.nlm.nih.gov/31862753/.

Fox CS, Khauta ea SH, Anderson C, et al. Nchafatso mabapi le thibelo ea lefu la pelo le batho ba baholo ba nang le lefu la tsoekere la mofuta oa 2 ho latela bopaki ba haufinyane: polelo ea mahlale e tsoang ho American Heart Association le American Diabetes Association. Tsamaiso. 2015; 132 (8): 691-718. PMID: 26246173 e fetotsoe.ncbi.nlm.nih.gov/26246173/.

Genest J, Libby P. Lipoprotein mathata le lefu la pelo. Ka: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Lefu la pelo la Braunwald: Buka ea bongaka ea meriana ea pelo. 11th ed. Philadelphia, PA: Elsevier; 2019: khaolo ea 48.

Grundy SM, Lejoe NJ, Bailey AL, et al. 2018 AHA / ACC / AACVPR / AAPA / ABC / ACPM / ADA / AGS / APhA / ASPC / NLA / PCNA Tataiso mabapi le taolo ea k'holeseterole ea mali: tlaleho ea American College of Cardiology / American Heart Association Task Force mabapi le Litataiso tsa Tloaelo ea Bongaka . J Ke Coll Cardiol. 2019; 73 (24): e285-e350. PMID: 30423393 e fetotsoe.ncbi.nlm.nih.gov/30423393/.

Sesole sa Ts'ireletso ea U.S. Polelo ea hoqetela ea hoqetela: tšebeliso ea molao bakeng sa thibelo ea mantlha ea lefu la pelo ho batho ba baholo: meriana ea thibelo. www.uspreventiveservicicestaskforce.org/Page/Document/RecommendationStatementFinal/statin-use-in-adult-preventive-medication1. E ntlafalitsoe ka Pulungoana 2016. E fihlile ka la 3 Hlakubele 2020.

Kakaretso ea khothaletso ea Sesole sa Ts'ireletso ea US. Tšebeliso ea Statin bakeng sa thibelo ea mantlha ea lefu la pelo ho batho ba baholo: meriana ea thibelo. www.uspreventiveservicestaskforce.org/uspstf/recommendation/statin-use-in-adult-preventive-medication. E ntlafalitsoe ka Pherekhong 2016. E fihlile ka la 24 Hlakola 2020.

• Angina
• Sebaka sa Angioplasty le stent - mothapo oa carotid
• Angioplasty le stent placement - methapo ea kutlo pheriferale
• Lefu la methapo ea Carotid
• Ho buuoa ka methapo ea Carotid - ho bulehile
• Coronary lefu la pelo
• Lefu la pelo
• Ho buuoa ke pelo
• Ho buuoa ka pelo - ho hlasela hanyane
• Lefu la pelo le lijo
• Likhahla tse phahameng tsa k'holeseterole ea mali
• Mothapo o potang leoto - leoto

• Ho lokisa mpa ea aortic aneurysm - ho bula - ho tsoa
• Angina - ho tsoa
• Angina - seo u lokelang ho se botsa ngaka ea hau
• Ho beoa ha Angioplasty le stent - mothapo oa carotid - ho tsoa
• Ho beoa ha angioplasty le stent - methapo ea methapo - ho tsoa
• Ho lokisa aortic aneurysm - endovascular - ho tsoa
• Atrial fibrillation - ho tsoa
• Botoro, majarine le oli ea ho pheha
• Ho buuoa ka methapo ea Carotid - ho tsoa
• Cholesterol - seo u lokelang ho se botsa ngaka ea hau
• Ho laola khatello ea mali e phahameng
• Ho hlalositsoe mafura a phepo
• Malebela a lijo tse potlakileng
• Lefu la pelo - ho tsoa
• Lefu la pelo - seo u lokelang ho se botsa ngaka ea hau
• Lefu la pelo - lisosa tse kotsi
• Ho hloleha ha pelo - seo u lokelang ho se botsa ngaka ea hau
• Khatello ea mali e phahameng - seo u lokelang ho se botsa ngaka ea hau
• Lijo tsa Mediterranean
• Pheriferale mothapo feta - leoto - tjhajoloha
• Stroke - ho tsoa

• Cholesterol
• Meriana ea Cholesterol
• Cholesterol e Phahameng ho Bana le Bacha
• LDL: Cholesterol "e Mpe"
• Lipolelo