Teko ea Smooth Muscle Antibody (SMA)

Litaba

• Teko ea smooth anti antibody (SMA) ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea SMA?
• Ho etsahalang nakong ea tlhahlobo ea SMA?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea SMA?
• Litšupiso

Teko ea smooth anti antibody (SMA) ke eng?

Teko ena e sheba li-antibodies tse boreleli tsa mesifa (SMAs) maling. Sesole sa 'mele se boreleli sa mesifa (SMA) ke mofuta oa antibody e tsejoang e le autoantibody. Ka tloaelo sesole sa hau sa 'mele se etsa masole a mmele ho hlasela lintho tse kantle ho naha joalo ka livaerase le libaktheria. Motho ea itšireletsang ka 'mele o hlasela lisele tsa' mele le lisele tsa hae ka phoso. Li-SMA li hlasela lisele tse boreleli sebeteng le likarolong tse ling tsa 'mele.

Haeba li-SMA li fumanoa maling a hau, ho ka etsahala hore ebe u na le lefu la sebete le itšireletsang. Ho itšireletsa mafung ke lefu la sebete le itšireletsang mafung. Ho na le mefuta e 'meli ea lefu la sebete le itšireletsang:

• Mofuta oa 1, mofuta o tloaelehileng haholo oa lefu lena. Mofuta oa 1 o ama basali ba bangata ho feta banna. E boetse e atile haholo ho batho ba nang le bothata bo bong ba 'mele.
• Mofuta oa 2, mofuta o sa tloaelehang oa lefu lena. Mofuta oa 2 o ama banana haholo ba pakeng tsa lilemo tse 2 le 14.

Ho itšireletsa mafung ha hepatitis ho ka laoloa ka meriana e hatellang sesole sa 'mele. Kalafo e sebetsa haholo ha lefu lena le fumanoa kapele. Ntle le kalafo, lefu la sebete le ikemetseng le ka baka mathata a tebileng a bophelo bo botle, ho kenyelletsa ho thatafala ha sebete le ho hloleha ha sebete.

Mabitso a mang: anti-boreleli ea mesifa e loantšanang, ASMA, antibody antibody, ACTA

E sebelisetsoa eng?

Teko ea SMA e sebelisoa haholo ho fumana lefu la sebete le itšireletsang. E boetse e sebelisetsoa ho fumana hore na lefu lena ke mofuta oa 1 kapa mofuta oa 2.

Liteko tsa SMA le tsona li sebelisoa khafetsa hammoho le liteko tse ling ho thusa ho netefatsa kapa ho felisa ho fumanoa ha lefu la sebete le ikemetseng. Liteko tsena tse ling li kenyelletsa:

• Teko ea lithibela-mafu tsa F-actin. F-actin ke protheine e fumanoang liseleng tse boreleli tsa mesifa ea sebete le likarolong tse ling tsa 'mele. Li-antibodies tsa F-actin li hlasela lisele tsena tse phetseng hantle.
• Teko ea ANA (antinuclear antibody). Li-ANA ke lithibela-mafu tse hlaselang khubung ea bohareng ba lisele tse itseng tse phetseng hantle.
• Liteko tsa ALT (alanine transaminase) le AST (aspartate aminotransferase). ALT le AST ke li-enzyme tse peli tse entsoeng ke sebete.

Hobaneng ha ke hloka tlhahlobo ea SMA?

U kanna ua hloka teko ena haeba uena kapa ngoana oa hau u na le matšoao a lefu la sebete la "autoimmune". Tsena li kenyelletsa:

• Mokhathala
• Jaundice (boemo bo etsang hore letlalo la hao le mahlo a be bosehla)
• Bohloko ba mpeng
• Bohloko bo kopaneng
• Ho nyekeloa
• Matlalo a letlalo
• Ho felloa ke takatso ea lijo
• Moroto o mmala o lefifi

Ho etsahalang nakong ea tlhahlobo ea SMA?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea SMA.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Haeba liphetho tsa hau li bontša li-antibodies tse ngata tsa SMA, mohlomong ho bolela hore o na le mofuta oa mofuta oa 1 oa lefu la sebete le itšireletsang. Chelete e tlase e ka bolela hore o na le mofuta oa 2 oa lefu lena.

Haeba ho ne ho sa fumanoe li-SMA, ho bolela hore matšoao a hau a sebete a bakoa ke ho hong ho fapaneng le lefu la sebete le itšireletsang. Mofani oa hao oa tlhokomelo ea bophelo o tla hloka ho odara liteko tse ling ho etsa tlhahlobo.

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea SMA?

Haeba liphetho tsa hau li bontšitse hore uena kapa ngoana oa hau le na le li-antibodies tsa SMA, mofani oa hau a ka laela biopsy ea sebete ho netefatsa hore o na le lefu la sebete le itšireletsang. Biopsy ke ts'ebetso e tlosang sampole e nyane ea liteko bakeng sa tlhahlobo.

Litšupiso

1. Mokhatlo oa American Liver. [Inthanete]. New York: American Liver Foundation; c2017. Autoimmune Hepatitis [e qotsitsoeng ka 2019 Aug 19]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/autoimmune-hepatitis/#information-for-the-newly-diagnosed
2. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC; Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Antinuclear Antibody (ANA) [e ntlafalitsoeng 2019 Mar 5; e qotsitsoeng 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/antinuclear-antibody-ana
3. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC; Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Li-autoantibodies [e ntlafalitsoeng 2019 ka la 28 Mots'eanong; e qotsitsoeng 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/autoantibodies
4. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC; Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Smooth Muscle Antibody (SMA) le F-actin Antibody [e ntlafalitsoeng ka la 2019 Mphalane 13; e qotsitsoeng 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/smooth-muscle-antibody-sma-and-f-actin-antibody
5. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2019. Autoimmune hepatitis: Matšoao le lisosa; 2018 Sep 12 [e qotsitsoeng ka 2019 Aug 19]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/autoimmune-hepatitis/symptoms-causes/syc-20352153
6. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: biopsy; [e qotsitsoeng ka la 2020 Phato 9]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/biopsy
7. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali [e qotsitsoeng ka 2019 Aug 19]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
8. Setsi sa Naha sa Ramatiki le Mafu a Musculoskeletal le a Letlalo [Marang-rang]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Mafu a Ikemetseng [a qotsitsoeng ka la 9 Phato 19]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.niams.nih.gov/health-topics/autoimmune-diseases
9. Setsi sa Naha sa Lefu la Ts'oaetso le Mafu a Ts'oaetso le Liphio [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Tlhaloso le Lintlha bakeng sa Hepatitis e Ikemetseng; 2018 Mots'eanong [e qotsitsoeng 2019 Aug 19]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/definition-facts
10. Setsi sa Naha sa Lefu la Ts'oaetso le Mafu a Ts'oaetso le Liphio [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Tlhahlobo ea Hepatitis e Ikemetseng; 2018 Mots'eanong [e qotsitsoeng 2019 Aug 19]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/diagnosis
11. Setsi sa Naha sa Lefu la Ts'oaetso le Mafu a Ts'oaetso le Liphio [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Matšoao le Lisosa tsa Hepatitis e Ikemetseng; 2018 Mots'eanong [e qotsitsoeng 2019 Aug 19]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/symptoms-causes
12. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Anti-anti-muscle antibody: Kakaretso [e ntlafalitsoeng 2019 Aug 19; e qotsitsoeng 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/anti-smooth-muscle-antibody
13. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Ho itšireletsa mafung hepatitis: Kakaretso [e ntlafalitsoeng 2019 Aug 19; e qotsitsoeng 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/autoimmune-hepatitis
14. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2019. Health Encyclopedia: Autoimmune Hepatitis [e qotsitsoeng ka 2019 Aug 19]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=85&contentid=P00657
15. Zeman MV, Hirschfield GM. Li-autoantibodies le lefu la sebete: Ts'ebeliso le tlhekefetso. Na J Gastroenterol [Inthanete]. 2010 Apr [e qotsitsoeng 2019 Aug 19]; 24 (4): 225-31. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864616

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.