Liteko tsa Pharmacogenetic
Litaba
- Ho etsa liteko tsa pharmacogenetic ke eng?
- E sebelisetsoa eng?
- Hobaneng ha ke hloka tlhahlobo ea meriana ea litlama?
- Ho etsahalang nakong ea tlhahlobo ea pharmacogenetic?
- Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
- Na ho na le likotsi tsa tlhahlobo?
- Liphetho li bolelang?
- Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea meriana ea litlama?
- Litšupiso
Ho etsa liteko tsa pharmacogenetic ke eng?
Pharmacogenetics, eo hape e bitsoang pharmacogenomics, ke thuto ea hore na liphatsa tsa lefutso li ama karabelo ea 'mele joang merianeng e itseng. Liphatsa tsa lefutso ke likarolo tsa DNA tse fetisitsoeng ho tsoa ho mme le ntate oa hau. Li na le tlhaiso-leseling e khethollang litšobotsi tsa hau tse ikhethang, joalo ka bophahamo le 'mala oa mahlo. Liphatsa tsa hau tsa lefutso le tsona li ka ama hore na sethethefatsi se itseng se ka ba kotsi ho uena joang.
Liphatsa tsa lefutso e ka ba lebaka la hore meriana e tšoanang ka lethal dose e tla ama batho ka litsela tse fapaneng haholo. Liphatsa tsa lefutso e kanna ea ba lebaka leo batho ba bang ba nang le litla-morao tse mpe moriana, athe ba bang ha ba na lona.
Tlhahlobo ea Pharmacogenetic e sheba liphatsa tsa lefutso tse khethehileng ho thusa ho fumana mefuta ea meriana le litekanyo tse ka u loketseng.
Mabitso a mang: pharmacogenomics, pharmacogenomic liteko
E sebelisetsoa eng?
Ho etsa liteko tsa Pharmacogenetic ho ka sebelisoa ho:
- Fumana hore na moriana o itseng o ka u thusa na
- Fumana hore na tekanyetso e ntle ka ho fetisisa e kanna ea ba efe ho uena
- Bolela esale pele hore na o tla ba le litla-morao tse tebileng tsa meriana
Hobaneng ha ke hloka tlhahlobo ea meriana ea litlama?
Mofani oa hao oa tlhokomelo ea bophelo a ka odara liteko tsena pele o qala moriana o itseng, kapa haeba o noa moriana o sa sebetseng le / kapa o bakang litla-morao tse mpe.
Liteko tsa Pharmacogenetic li fumaneha feela bakeng sa palo e lekanyelitsoeng ea meriana. Ka tlase ke meriana le liphatsa tsa lefutso tse ka hlahlojoang. (Hangata mabitso a liphatsa tsa lefutso a fanoa ka litlhaku le lipalo.)
Moriana | Liphatsa tsa lefutso |
---|---|
Warfarin: mali a tšesaane | CYP2C9 le VKORC1 |
Plavix, mali a tšesaane | EA-19-CYP2C19 |
Ho imeloa kelellong, meriana ea lefu la sethoathoa | CYP2D6, CYPD6 CYP2C9, CYP1A2, SLC6A4, HTR2A / C |
Tamoxifen, kalafo ea mofetše oa matsoele | CYPD6 |
Lithibela-mafu | E ETSAHALA, CYP2D6, CYP2C19, CYP1A2 |
Kalafo ea bothata ba khaello ea tlhokomelo | D4D4 |
Carbamazepine, kalafo ea lefu la sethoathoa | EA-1502-HLA |
Abacavir, kalafo ea HIV | HLA-B 5701 |
Li-opioids | OPRM1 |
Statins, meriana e phekolang k'holeseterole e phahameng | SLCO1B1 |
Kalafo ea kankere ea mali ea bongoana le mathata a itseng a ho itšireletsa mafung | TMPT |
Ho etsahalang nakong ea tlhahlobo ea pharmacogenetic?
Ho etsa liteko hangata ho etsoa maling kapa mathe.
Bakeng sa teko ea mali, setsebi sa tlhokomelo ea bophelo se tla nka sampole ea mali mothapong o letsohong la hao, a sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.
Bakeng sa teko ea mathe, botsa mofani oa tlhokomelo ea bophelo bakeng sa litaelo tsa hore na u ka fana ka sampole ea hau joang.
Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
Hangata ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea mali. Haeba u etsa tlhahlobo ea mathe, ha ua lokela ho ja, ho noa kapa ho tsuba metsotso e 30 pele ho tlhahlobo.
Na ho na le likotsi tsa tlhahlobo?
Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.
Ha ho na kotsi ea ho etsa teko ea mathe.
Liphetho li bolelang?
Haeba o ile oa hlahlojoa pele o qala kalafo, tlhahlobo e ka bonts'a hore na moriana o tla sebetsa hantle le / kapa haeba o kotsing ea litla-morao tse tebileng. Liteko tse ling, joalo ka tsa litlhare tse ling tse phekolang lefu la sethoathoa le HIV, li ka bontša hore na u kotsing ea litla-morao tse sokelang bophelo. Haeba ho joalo, mofani oa hau o tla leka ho fumana kalafo e ngoe.
Liteko tse etsahalang pele le ha o le kalafong li ka thusa mofani oa hao oa tlhokomelo ea bophelo ho fumana lethal dose e nepahetseng.
Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.
Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.
Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea meriana ea litlama?
Ho etsa liteko tsa Pharmacogenetic ho sebelisoa feela ho fumana karabelo ea motho moriana o itseng. Ha ho tšoane le ho etsa liteko tsa lefutso. Boholo ba liteko tsa liphatsa tsa lefutso li sebelisoa ho thusa ho fumana mafu kapa likotsi tse ka bang teng tsa mafu, ho supa kamano ea lelapa, kapa ho tseba motho e mong lipatlisisong tsa botlokotsebe.
Litšupiso
- Hefti E, Blanco J. Ho ngola teko ea Pharmacogenomic Testing with Current Procedure Terminology (CPT) Codes, Tlhahlobo ea Mekhoa ea Khale le ea Hona Joale. J AHIMA [Inthanete]. 2016 Jan [e qotsitsoeng 2018 Jun 1]; 87 (1): 56-9. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
- Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. Liteko tsa Pharmacogenetic; [e ntlafalitsoeng 2018 Jun 1; e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/pharmacogenetic-tests
- Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. Bokahohle ba Teko ea Liphatsa tsa lefutso; [e ntlafalitsoeng 2017 Nov 6; e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/articles/genetic-testing?start=4
- Mayo Clinic: Setsi sa Bongaka bo Ikhethileng [Marang-rang]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. Teko ea Gene-lithethefatsi; [e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
- Mayo Clinic: Setsi sa Bongaka bo Ikhethileng [Marang-rang]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. Tlhahlobo ea CYP2D6 / Tamoxifen Pharmacogenomic Lab; [e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 5].E fumaneha ho tsoa ho: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
- Mayo Clinic: Setsi sa Bongaka bo Ikhethileng [Marang-rang]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. HLA-B 1502 / Carbamazepine Pharmacogenomic Lab Teko; [e qotsitsoeng 2018 Jun 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab1502-carbamazephine.asp
- Mayo Clinic: Setsi sa Bongaka bo Ikhethileng [Marang-rang]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. HLA-B 5701 / Abacavir Pharmacogenomic Lab Teko; [e qotsitsoeng 2018 Jun 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab5701-abacavir.asp
- Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2018. ID ea Teko: PGXFP: Phanele ea Pharmacogenomics e tsepamisitsoeng: Setšoantšo; [e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
- Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukantswe ya NCI ya Dipehelo tsa Kankere: gene; [e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=gene
- National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
- Setsi sa Naha sa Naha sa Saense ea Bongaka ea Bongaka [Marang-rang]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Pharmacogenomics; [e ntlafalitsoeng ka 2017 Oct; e qotsitsoeng 2018 Jun 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx
- NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Pharmacogenomics ke eng ?; 2018 Mots'eanong 29 [e qotsitsoeng 2018 Jun 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics
- Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Univesithi ea Florida; c2018. Kamoo liphatsa tsa hau tsa lefutso li susumetsang meriana e u loketseng ka teng; 2016 Jan 11 [e ntlafalitsoeng 2018 Jun 1; e qotsitsoeng 2018 Jun 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/blog/how-your-genes-influence-what-medicines-are-right-you
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Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.