Liteko tsa PDL1 (Immunotherapy)

Litaba

• Teko ea PDL1 ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka teko ea PDL1?
• Ho etsahalang nakong ea teko ea PDL1?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea PDL1?
• Litšupiso

Teko ea PDL1 ke eng?

Teko ena e lekanya palo ea PDL1 liseleng tsa mofetše. PDL1 ke protheine e thusang ho boloka lisele tsa 'mele tsa ho itšireletsa mafung li sa hlasele lisele tse seng kotsi' meleng. Ka tloaelo sesole sa 'mele se loantša lintho tse kantle ho naha joalo ka livaerase le libaktheria, eseng lisele tsa hau tse phetseng hantle. Lisele tse ling tsa mofetše li na le PDL1 e ngata. Sena se lumella lisele tsa mofets'e ho "qhekella" sesole sa 'mele, le ho qoba ho hlaseloa joalo ka lintho tse tsoang kantle ho naha tse kotsi.

Haeba lisele tsa hau tsa mofetše li na le PDL1 e ngata, o ka rua molemo kalafong e bitsoang immunotherapy. Immunotherapy ke kalafo e matlafatsang sesole sa hau sa 'mele ho e thusa ho tseba le ho loantša lisele tsa mofetše. Immotherapy e bontšitsoe e sebetsa haholo ho phekola mefuta e meng ea mofetše. E boetse e na le litla-morao tse fokolang ho feta litlhare tse ling tsa mofets'e.

Mabitso a mang: lefu-ligand 1, PD-LI, PDL-1 e entsoe ke immunohistochemistry (IHC)

E sebelisetsoa eng?

Tlhahlobo ea PDL1 e sebelisetsoa ho fumana hore na o na le mofetše o ka ruang molemo ho immunotherapy.

Hobaneng ha ke hloka teko ea PDL1?

U kanna oa hloka tlhahlobo ea PDL1 haeba u fumanoe u na le e 'ngoe ea mofetše o latelang.

• Kankere ea matšoafo e seng e nyane
• Melanoma
• Hodgkin lymphoma
• Kankere ea senya
• Kankere ea liphio
• Kankere ea matsoele

Methati e phahameng ea PDL1 hangata e fumanoa ho tsena, hammoho le mefuta e meng ea mofets'e. Kankere e nang le maemo a phahameng a PDL1 hangata e ka phekoloa ka katleho ka immunotherapy.

Ho etsahalang nakong ea teko ea PDL1?

Liteko tse ngata tsa PDL1 li etsoa ka mokhoa o bitsoang biopsy. Ho na le mefuta e meraro ea mantlha ea lits'ebetso tsa biopsy:

• Phofo e ntle ea nale, e sebedisang nale e tshesane haholo ho ntsha sampole ya disele kapa lero
• Nete ​​ea biopsy, e sebelisang nale e kholo ho tlosa sampole
• Ho buoa biopsy, e tlosang sampole ts'ebetsong e nyane ea bakuli

Takatso e ntle ea nale le li-biopsies tsa mantlha tsa nale hangata ho kenyelletsa mehato e latelang:

• U tla robala ka lehlakore kapa u lule tafoleng ea liteko.
• Mofani oa tlhokomelo ea bophelo o tla hloekisa sebaka sa biopsy mme a se ente ka moriana o thethefatsang e le hore o se utloe bohloko nakong ea ts'ebetso.
• Hang ha sebaka seo se felloa ke matla, mofani oa thepa o tla kenya nale e ntle ea aspiration kapa nale ea mantlha ea biopsy sebakeng sa biopsy ebe o tlosa sampuli ea lisele kapa mokelikeli.
• U kanna oa utloa khatello e nyane ha sampole e huloa.
• Khatello e tla sebelisoa sebakeng sa biopsy ho fihlela mali a emisa.
• Mofani oa hau o tla kenya bandage e nyopa sebakeng sa biopsy.

Ka biopsy ea ho buoa, Ngaka e buoang e tla itšeha hanyane letlalong la hao ho tlosa leqhubu la letsoele kaofela kapa karolo ea lona. Ka linako tse ling biopsy ea ho buoa e etsoa haeba hlama e ke ke ea fihleloa ka nalane ea nale. Hangata li-biopsies tsa ho buoa li kenyelletsa mehato e latelang.

• U tla robala tafoleng ea ts'ebetso. Ho ka beoa IV (mohala o kenang methapong) letsohong kapa letsohong.
• U kanna ua fuoa moriana, o bitsoang sedative, ho u thusa ho phomola.
• U tla fuoa anesthesia ea lehae kapa e akaretsang hore u se ke oa utloa bohloko nakong ea ts'ebetso.
  • Bakeng sa anesthesia ea lehae, mofani oa tlhokomelo ea bophelo o tla kenya setša sa biopsy ka meriana ho felisa sebaka seo.
  • Bakeng sa thethebatso e akaretsang, setsebi se bitsoang anesthesiologist se tla u fa moriana hore o tle o tsebe letho nakong ea ts'ebetso.
• Hang ha sebaka sa biopsy se felloa ke matla kapa u sa tsebe letho, ngaka e buoang e tla poma hanyenyane ka letsoeleng ebe e tlosa karolo kapa kotola kaofela. Lisele tse ling tse potileng hlama le tsona li ka tlosoa.
• Sehiloeng letlalong la hao se tla koaloa ka lithupa kapa likotoana tsa khomaretsi.

Ho na le mefuta e fapaneng ea li-biopsies. Mofuta oa biopsy oo u o fumanang o tla itšetleha ka sebaka le boholo ba hlahala ea hau.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

U ke ke ua hloka litokisetso tse khethehileng haeba u fumana anesthesia ea lehae (ho koaloa ha sebaka sa biopsy). Haeba u fumana anesthesia ka kakaretso, mohlomong u tla hloka ho itima lijo (u se ke ua ja kapa ua noa) lihora tse 'maloa pele u etsoa opereishene. Ngaka ea hao e buoang e tla u fa litaelo tse tobileng. Hape, haeba u fumana moriana o thethefatsang kapa o thetsang, etsa bonnete ba hore o hlophisa hore motho e mong au khannele hae. O kanna oa ba groggy mme oa ferekana kamora ho tsoha ts'ebetsong.

Na ho na le likotsi tsa tlhahlobo?

U kanna oa ba le maqeba kapa ho tsoa mali hanyane sebakeng sa biopsy. Ka linako tse ling sebaka seo se a tšoaetsoa. Haeba seo se etsahala, o tla phekoloa ka lithibela-mafu. Biopsy ea ho buoa e ka baka bohloko le pherekano tse ling. Mofani oa hao oa tlhokomelo ea bophelo a ka u khothaletsa kapa a u fa meriana ho u thusa hore u ikutloe u le betere.

Liphetho li bolelang?

Haeba liphetho tsa hau li bontša hore lisele tsa hau tsa hlahala li na le PDL1 e phahameng, o kanna oa qala ho immunotherapy. Haeba liphetho tsa hau li sa bontše maemo a phahameng a PDL1, immunotherapy e kanna ea se sebetse ho uena. Empa o kanna oa rua molemo mofuteng o mong oa kalafo ea mofets'e. Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea PDL1?

Immunotherapy ha e sebetse bakeng sa motho e mong le e mong, leha o na le lihlahala tse nang le maemo a phahameng a PDL1. Lisele tsa mofetše li rarahane ebile hangata ha li tsejoe esale pele. Bafani ba tlhokomelo ea bophelo le bafuputsi ba ntse ba ithuta ka immunotherapy le mokhoa oa ho tseba esale pele hore na ke mang ea tla una molemo haholo kalafong ena.

Litšupiso

1. Allina Health [Inthanete]. Minneapolis: Bophelo bo Botle ba Allina; c2018. Immunotherapy bakeng sa mofetše; [e qotsitsoeng 2018 Aug 14]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://wellness.allinahealth.org/library/content/60/903
2. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Li-inhibitors tsa boits'ireletso ba mmele ho alafa mofetše; [e ntlafalitsoeng 2017 May 1; e qotsitsoeng 2018 Aug 14]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/immune-checkpoint-inhibitors.html
3. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Phekolo ea Kankere e reretsoeng ke eng ?; [e ntlafalitsoeng 2016 Jun 6; e qotsitsoeng 2018 Aug 14]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
4. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Ke eng e ncha lipatlisisong tsa immunotherapy tsa mofetše ?; [e ntlafalitsoeng 2017 Oct 31; e qotsitsoeng 2018 Aug 14]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html
5. Kankere.Net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Lintho Tse 9 Tseo U Lokelang ho li Tseba ka Immunotherapy le Kankere ea Lung; 2016 Nov 8 [e qotsitsoeng ka 2018 Aug 14]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.net/blog/2016-11/9-things-now-about-immunotherapy-and-lung-cancer
6. Setsi sa Kankere sa Dana-Farber [Internet]. Boston: Setsi sa Kankere sa Dana-Farber; c2018. Teko ea PDL-1 ke eng ?; 2017 Mots'eanong 22 [e ntlafalitsoeng 2017 Jun 23; e qotsitsoeng 2018 Aug 14]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://blog.dana-farber.org/insight/2017/05/what-is-a-pd-l1-test
7. Oncology e Kopaneng [Inthanete]. Laboratori ea Amerika, c2018. PDL1-1 ke IHC, Opdivo; [e qotsitsoeng 2018 Aug 14]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.integratedoncology.com/test-menu/pd-l1-by-ihc-opdivo%C2%AE/cec2cfcc-c365-4e90-8b79-3722568d5700
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Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.