Nicotinamide Riboside: Melemo, Litlamorao le Tekanyo

Litaba

• Nicotinamide Riboside ke eng?
• Melemo e ka bang teng
• Fetolela habonolo ho NAD +
• E kenya li-enzyme tse ka 'nang tsa khothalletsa botsofali
• E kanna ea Thusa ho Sireletsa Lisele tsa Boko
• E ka Fokotsa Kotsi ea Maloetse a Pelo
• Melemo e meng e ka bang teng
• Likotsi tse ka bang teng le litlamorao
• Tekanyo le Litlhahiso
• Ntlha ea Bohlokoa

Selemo se seng le se seng, Maamerika a sebelisa lidolara tse libilione ho lihlahisoa tse loantšang botsofali.

Le ha lihlahisoa tse ngata tse khahlanong le botsofali li leka ho etsolla matšoao a botsofali letlalong la hao, nicotinamide riboside - eo hape e bitsoang niagen - e ikemiselitse ho khutlisa matšoao a botsofali kahare ho mmele oa hau.

Ka har'a 'mele oa hau, nicotinamide riboside e fetoloa NAD +, molek'hule e thusang e teng kahare ho lisele tsohle tsa hau mme e ts'ehetsa likarolo tse ngata tsa botsofali bo phetseng hantle.

Sengoloa sena se hlalosa tsohle tseo u hlokang ho li tseba ka nicotinamide riboside, ho kenyelletsa melemo ea eona, litla-morao le litekanyetso.

Nicotinamide Riboside ke eng?

Nicotinamide riboside, kapa niagen, ke mofuta o mong oa vithamine B3, eo hape e bitsoang niacin.

Joalo ka mefuta e meng ea vithamine B3, nicotinamide riboside e fetoloa ke 'mele oa hau ho nicotinamide adenine dinucleotide (NAD +), coenzyme kapa molek'hule ea mothusi.

NAD + e sebetsa e le mafura bakeng sa lits'ebetso tse ngata tsa bohlokoa tsa bioloji, joalo ka (,):

• Ho fetola lijo hore e be matla
• Ho lokisa DNA e senyehileng
• Ho matlafatsa lisele tsa boits'ireletso
• Ho beha oache ea kahare ea 'mele oa hau kapa morethetho oa circadian

Leha ho le joalo, palo ea NAD + 'meleng oa hau ka tlhaho e oa ka lilemo ().

Maemo a tlase a NAD + a hokahane le mathata a bophelo bo botle joalo ka botsofali le mafu a sa foleng, joalo ka lefu la tsoekere, lefu la pelo, lefu la Alzheimer le tahlehelo ea pono ().

Ho khahlisang ke hore lipatlisiso tsa liphoofolo li fumane hore ho phahamisa maemo a NAD + ho ka thusa ho khutlisa matšoao a botsofali le ho fokotsa menyetla ea mafu a mangata a sa foleng (,,).

Lisebelisoa tsa Nicotinamide riboside - joalo ka niagen - li se li tsebahala kapele hobane li bonahala li sebetsa haholo ho phahamiseng maemo a NAD + ().

Nicotinamide riboside e boetse e fumanoa ka bongata ba lebese la likhomo, tomoso le biri ().

Nicotinamide riboside, kapa niagen, ke mofuta o mong oa vithamine B3. E khothalletsoa e le tlatsetso e khahlanong le botsofali hobane e matlafatsa maemo a 'mele oa hau a NAD +, a sebetsang e le mafura bakeng sa lits'ebetso tse ngata tsa bohlokoa tsa bioloji.

Melemo e ka bang teng

Hobane lipatlisiso tse ngata tsa nicotinamide riboside le NAD + li tsoa liphuputsong tsa liphoofolo, ha ho liqeto tse hlakileng tse ka etsoang mabapi le katleho ea eona ho batho.

Seo se boletse, mona ke melemo e meng e ka bang teng ea bophelo bo botle ba nicotinamide riboside.

Fetolela habonolo ho NAD +

NAD + ke coenzyme, kapa molek'hule e thusang, e nkang karolo liketsong tse ngata tsa bioloji.

Ha e ntse e le bohlokoa bakeng sa bophelo bo botle, lipatlisiso li bonts'a hore maemo a NAD + a ntse a tsoela pele ho theoha ka lilemo. Maemo a tlase a NAD + a hokahane le botsofe bo futsanehileng le mafu a fapaneng a kotsi (,).

Tsela e 'ngoe ea ho nyolla maemo a NAD + ke ho sebelisa li-precurs tsa NAD + - li-block tsa NAD + - joalo ka nicotinamide riboside.

Liphuputso tsa liphoofolo li bontša hore nicotinamide riboside e phahamisa maemo a mali a NAD + ho fihlela makhetlo a 2.7. Ho feta moo, e sebelisoa habonolo ke 'mele oa hau ho feta tse ling tsa pele ho NAD + ().

E kenya li-enzyme tse ka 'nang tsa khothalletsa botsofali

Nicotinamide riboside e thusa ho eketsa maemo a NAD + 'meleng oa hau.

Ha e arabela, NAD + e kenya li-enzyme tse itseng tse ka khothalletsang botsofali bo botle.

Sehlopha se seng ke li-sirtuine, tse bonahalang li ntlafatsa bophelo le bophelo bo botle ba liphoofolo. Liphuputso li bonts'a hore li-sirtuine li ka lokisa DNA e senyehileng, tsa matlafatsa khatello ea maikutlo, tsa fokotsa ho ruruha le ho fana ka melemo e meng e khothalletsang botsofali bo botle (,,).

Li-Sirtuin le tsona li ikarabella bakeng sa melemo ea ho phela ka nako e telele ea thibelo ea likhalori ().

Sehlopha se seng ke Poly (ADP-Ribose) polymerases (PARPs), e lokisang DNA e senyehileng. Liphuputso li hokahanya ts'ebetso e phahameng ea PARP le tšenyo e nyane ea DNA le nako e telele ea bophelo (,).

E kanna ea Thusa ho Sireletsa Lisele tsa Boko

NAD + e bapala karolo ea bohlokoa ho thuseng lisele tsa hau tsa boko ho tsofala hantle.

Ka har'a lisele tsa boko, NAD + e thusa ho laola tlhahiso ea PGC-1-alpha, protheine e bonahalang e thusa ho sireletsa lisele khahlano le khatello ea mali le ts'ebetso ea mitochondrial ().

Bafuputsi ba lumela hore khatello ea mali le khatello ea ts'ebetso ea mitochondrial li hokahane le mathata a amanang le lilemo tse kang lefu la Alzheimer's le Parkinson (,,).

Ho litoeba tse nang le lefu la Alzheimer, nicotinamide riboside e phahamisitse maemo a boko NAD + le tlhahiso ea PGC-1-alpha ho fihlela 70% le 50%, ka ho latellana. Qetellong ea thuto, litoeba li ne li sebetsa hantle haholo mesebetsing e thehiloeng mohopolong ().

Phuputsong ea tube-test, nicotinamide riboside e phahamisitse maemo a NAD + mme e ntlafalitse haholo ts'ebetso ea mitochondrial liseleng tsa bakoang tse nkiloeng ho mokuli oa lefu la Parkinson ().

Leha ho le joalo, ho ntse ho sa hlaka hore na ho thusa hakae ho phahamisa maemo a NAD + ho batho ba nang le mathata a amanang le boko. Ho hlokahala lithuto tse ling tsa batho.

E ka Fokotsa Kotsi ea Maloetse a Pelo

Ho tsofala ke kotsi e kholo ea lefu la pelo, e leng sesosa se ka sehloohong sa lefu ().

E ka etsa hore methapo ea mali e joalo ka aorta ea hau e be motenya, e thatafale mme e se ke ea fetoha habonolo.

Liphetoho tse joalo li ka nyolla khatello ea mali mme tsa etsa hore pelo ea hau e sebetse ka thata.

Liphoofolong, ho holisa NAD + ho thusitse liphetoho tse amanang le lilemo ho methapo ().

Ho batho, nicotinamide riboside e phahamisitse maemo a NAD +, e thusitse ho fokotsa ho satalla ho aorta le ho theola khatello ea mali ea systolic ho batho ba baholo ba kotsing ea khatello e phahameng ea mali (22).

Seo se boletse, lipatlisiso tse ngata tsa batho lia hlokahala.

Melemo e meng e ka bang teng

Ntle le moo, nicotinamide riboside e ka fana ka melemo e meng e mengata:

• E ka thusa ho theola boima ba 'mele: Nicotinamide riboside e thusitse ho potlakisa metabolism ea litoeba. Leha ho le joalo, ha ho hlake hore na e tla ba le phello e ts'oanang bathong le hore na phello ee e matla hakae ().
• E ka fokotsa kotsi ea mofets'e: Methati e phahameng ea NAD + e thusa ho itšireletsa khahlanong le tšenyo ea DNA le khatello ea mali e amanang le kholo ea mofets'e (,).
• E ka thusa ho sebetsana le jet lag: NAD + e thusa ho laola tšupa-nako ea 'mele oa hau, ka hona ho nka niagen ho ka thusa ho alafa jet lag kapa mathata a mang a pina ea circadian ka ho hlophisa oache ea kahare ea' mele oa hau.
• E kanna ea khothaletsa botsofali bo botle ba mesifa: Ho phahamisa maemo a NAD + ho thusitse ho ntlafatsa ts'ebetso ea mesifa, matla le mamello ho litoeba tsa khale (,).

Nicotinamide riboside e eketsa maemo a NAD +, a hokahaneng le melemo e ka bang teng mabapi le bophelo bo botle mabapi le botsofali, bophelo bo botle ba kelello, kotsi ea lefu la pelo le tse ling.

Likotsi tse ka bang teng le litlamorao

Nicotinamide riboside e sireletsehile ha ho na le litla-morao tse fokolang - haeba li le teng.

Lithutong tsa batho, ho nka 1,000-2,000 mg ka letsatsi ho ne ho se na litlamorao tse mpe (,).

Leha ho le joalo, lithuto tsa batho tse ngata li khuts'oane ka nako ebile li na le barupeluoa ba fokolang haholo. Bakeng sa mohopolo o nepahetseng haholoanyane oa polokeho ea eona, ho hlokahala lithuto tsa batho tse matlafatsang.

Batho ba bang ba tlalehile litla-morao tse bobebe ho isa ho tse itekanetseng, joalo ka ho nyekeloa ke pelo, mokhathala, ho opeloa ke hlooho, letshollo, ho se utloise bohloko ka mpeng le ho qhalana ().

Liphoofolong, ho nka 300 mg ka kg ea boima ba 'mele (136 mg ka ponto) letsatsi le leng le le leng bakeng sa matsatsi a 90 ho ne ho se na litlamorao tse kotsi ().

Ho feta moo, ho fapana le li-supplement tsa vithamine B3 (niacin), nicotinamide riboside ha ea lokela ho baka ho tsubella sefahlehong ().

Nicotinamide riboside e bonahala e sireletsehile ka litla-morao tse fokolang. Leha ho le joalo, litlamorao tsa eona tsa nako e telele bathong li ntse li sa tsejoe.

Tekanyo le Litlhahiso

Nicotinamide riboside e fumaneha ka foromo ea letlapa kapa capsule mme e bitsoa niagen.

E fumaneha mabenkeleng a khethehileng a lijo, ho Amazon kapa ka barekisi ba inthaneteng.

Niagen e tlatselletsa hangata e na le nicotinamide riboside feela, empa baetsi ba bang ba e kopanya le metsoako e meng e kang Pterostilbene, e leng polyphenol - antioxidant e nang le lik'hemik'hale tse tšoanang le resveratrol ().

Mefuta e mengata ea tlatsetso ea niagen e khothaletsa ho noa 250-300 mg ka letsatsi, e lekanang le li-capsules tse 1-2 ka letsatsi ho latela lebitso.

Boholo ba baetsi ba niagen ba khothaletsa ho noa nicotinamide riboside ka 250-300 mg ka letsatsi.

Ntlha ea Bohlokoa

Nicotinamide riboside ke mofuta o mong oa vithamine B3 o nang le litla-morao tse fokolang. Hangata e rekisoa e le sehlahisoa se khahlanong le botsofali.

'Mele oa hau o o fetola NAD +, e fehlang lisele tsohle tsa hau. Ha maemo a NAD + a theoha ka tlhaho ka lilemo, ho eketsa maemo a NAD + ho ka fetola matšoao a 'maloa a botsofali.

Leha ho le joalo, lipatlisiso tse ngata tsa nicotinamide riboside le NAD + li liphoofolong. Ho hlokahala lithuto tsa boleng bo holimo tsa batho pele ba e khothaletsa joalo ka kalafo.