Lefu la Huntington: ke eng, matšoao, sesosa le kalafo

Litaba

• Matšoao a mantlha
• Sesosa sa lefu la Huntington
• Kalafo e etsoa joang

Lefu la Huntington, le tsejoang hape e le Huntington's chorea, ke lefu le sa tloaelehang la liphatsa tsa lefutso le bakang ho se sebetse ha motsamao, boitšoaro le bokhoni ba ho bua. Matšoao a lefu lena a ntse a tsoela pele, mme a ka qala lipakeng tsa lilemo tse 35 ho isa ho tse 45, mme ho hlahlojoa maemong a pele ho thata haholo ka lebaka la hore matšoao a ts'oana le a mafu a mang.

Lefu la Huntington ha le na pheko, empa ho na le likhetho tsa kalafo ka meriana e thusang ho kokobetsa matšoao le ho ntlafatsa bophelo, bo lokelang ho laeloa ke ngaka ea methapo kapa ngaka ea mafu a kelello, joalo ka lithibela-mafu le khatello ea maikutlo, ho ntlafatsa khatello ea maikutlo le khatello ea maikutlo, kapa Tetrabenazine, ho ntlafatsa liphetoho motsamao le boits'oaro.

Matšoao a mantlha

Matšoao a lefu la Huntington a ka fapana ho ea ka motho, 'me a ka tsoela pele kapele kapa a ba matla haholo ho latela hore na kalafo e etsoa kapa che. Matšoao a mantlha a amanang le lefu la Huntington ke ana:

• Mekhatlo e potlakileng ea boits'oaro, e bitsoang chorea, tse qalang li le karolong e le 'ngoe ea' mele, empa eo ha nako e ntse e tsamaea e amang likarolo tse fapaneng tsa 'mele.
• Ho thata ho tsamaea, ho bua le ho shebahala, kapa liphetoho tse ling tsa motsamao;
• Ho thatafala kapa ho thothomela ea mesifa;
• Liphetoho tsa boitšoaro, ka khatello ea maikutlo, tloaelo ea ho ipolaea le psychosis;
• Mehopolo ea fetoha, le mathata a ho buisana;
• Ho thata ho bua le ho koenya, ho eketsa kotsi ea ho bipetsoa.

Ntle le moo, maemong a mang ho ka ba le liphetoho borokong, ho theola boima ba 'mele ka boomo, ho fokotseha kapa ho se khone ho etsa metsamao ea boithatelo. Chorea ke mofuta oa lefu le khetholloang ka ho ba mokhutšoane, joalo ka spasm, e ka etsang hore lefu lena le ferekanngoe le mathata a mang, joalo ka stroke, Parkinson's, Tourette's syndrome kapa ho nkuoa e le litholoana tsa ts'ebeliso ea meriana e meng.

Ka hona, boteng ba matšoao le matšoao a Huntington's syndrome, haholo haeba ho na le nalane ea lefu leo ​​ka lapeng, ho bohlokoa ho ikopanya le ngaka e akaretsang kapa ngaka ea methapo e le hore tlhahlobo ea matšoao le matšoao motho o entsoe, hammoho le liteko tsa ts'ebetso ea ho nka litšoantšo tse kang computed tomography kapa magnetic resonance imaging le liteko tsa lefutso ho netefatsa phetoho le ho qala kalafo.

Sesosa sa lefu la Huntington

Lefu la Huntington le hlaha ka lebaka la phetoho ea liphatsa tsa lefutso, e fetisoang ka tsela ea lefutso, mme e khethollang ho senyeha ha libaka tsa bohlokoa tsa boko. Phetoho ea lefutso ea lefu lena ke ea mofuta o hlahelletseng, ho bolelang hore ho lekane ho rua lefutso ho e mong oa batsoali hore ba be kotsing ea ho le tšoaroa.

Kahoo, ka lebaka la phetoho ea liphatsa tsa lefutso, ho hlahisoa mofuta o fetotsoeng oa protheine, e lebisang lefung la lisele tsa methapo likarolong tse ling tsa boko mme e rata nts'etsopele ea matšoao.

Kalafo e etsoa joang

Kalafo ea lefu la Huntington e lokela ho etsoa tlasa tataiso ea ngaka ea methapo le ngaka ea mafu a kelello, e tla lekola boteng ba matšoao le ho tataisa ts'ebeliso ea litlhare ho ntlafatsa bophelo ba motho. Kahoo, meriana e meng e ka bonts'ang ke:

• Lipheko tse laolang motsamao lia fetoha, joalo ka Tetrabenazine kapa Amantadine, kaha li sebetsa ho li-neurotransmitters bokong ho laola mefuta ena ea liphetoho;
• Meriana e laolang psychosis, joalo ka Clozapine, Quetiapine kapa Risperidone, e thusang ho fokotsa matšoao a kelello le liphetoho tsa boits'oaro;
• Ho imeloa kelellong, joalo ka Sertraline, Citalopram le Mirtazapine, e ka sebelisoang ho ntlafatsa maikutlo le ho khutsisa batho ba ferekaneng haholo;
• Ho tsitsisa maikutlo, joalo ka Carbamazepine, Lamotrigine le Valproic acid, tse bonts'itsoeng ho laola tšusumetso ea boitšoaro le likhatello.

Ts'ebeliso ea meriana ha e ea hlokahala kamehla, e sebelisoa feela moo ho nang le matšoao a tšoenyang motho. Ntle le moo, ho etsa mesebetsi ea boipheliso, joalo ka kalafo ea 'mele kapa kalafo ea mosebetsing, ho bohlokoa haholo ho thusa ho laola matšoao le ho fetola motsamao.