Teko ea Antibody ea CCP

Litaba

• Teko ea lesole la CCP ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea lesole la 'mele ea CCP?
• Ho etsahalang nakong ea tlhahlobo ea lesole la CCP?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea lesole la CCP?
• Litšupiso

Teko ea lesole la CCP ke eng?

Teko ena e sheba li-antibodies tsa CCP (cyclic citrullinated peptide) maling. Masole a mmele a CCP, ao hape a bitswang anti-CCP antibodies, ke mofuta wa lesole la mmele le bitswang autoantibodies. Masole a 'mele le li-autoantibodies ke liprotheine tse entsoeng ke sesole sa' mele. Masole a mmele a o sireletsa mafung ka ho lwantsha dintho tse kantle tse kang divaerase le baktheria. Li-autoantibodies li ka baka mafu ka ho hlasela lisele tse phetseng hantle tsa 'mele ka phoso.

Lisireletsi tsa CCP li lebisa lisele tse phetseng hantle manonyellong. Haeba li-antibodies tsa CCP li fumanoa maling a hau, e ka ba sesupo sa ramatiki ea ramatiki. Ramatiki ea mafu ke lefu le tsoelang pele, le ikemetseng le bakang bohloko, ho ruruha le ho satalla manonyeletso. Masole a mmele a CCP a fumanwa ho batho ba fetang diphesente tse 75 tsa batho ba nang le ramatiki ya ramatiki. Hoo e ka bang ha ho mohla li fumanoang ho batho ba se nang lefu lena.

Mabitso a mang: Sesole sa peptide sa cyclic citrullinated peptide, anti -rrinated peptide antibody, citrulline antibody, anti-cyclic citrullinated peptide, anti-CCP antibody, ACPA

E sebelisetsoa eng?

Ho sebelisoa tlhahlobo ea lesole la CCP ho thusa ho fumana ramatiki ea ramatiki. Hangata e etsoa hammoho kapa kamora tlhahlobo ea ramatiki (RF). Lisosa tsa ramatiki ke mofuta o mong oa autoantibody. Liteko tsa RF e ne e le teko ea mantlha ho thusa ho fumana ramatiki ea ramatiki. Empa lintlha tsa RF li ka fumanoa ho batho ba nang le mafu a mang a ikemetseng esita le ho batho ba bang ba phetseng hantle. Liphuputso tse ngata li bonts'itse hore lithibela-mafu tsa CCP li fana ka tlhahlobo e nepahetseng ea ramatiki ea ramatiki ha e bapisoa le tlhahlobo ea RF.

Hobaneng ha ke hloka tlhahlobo ea lesole la 'mele ea CCP?

U kanna ua hloka teko ena haeba u na le matšoao a ramatiki ea lefu la masapo. Tsena li kenyelletsa:

• Bohloko bo kopaneng
• Ho satalla ho kopaneng, haholo hoseng
• Ho ruruha ho kopaneng
• Mokhathala
• Feberu e tlaase

U kanna ua hloka tlhahlobo ena haeba liteko tse ling li sa khone ho netefatsa kapa ho thibela tlhahlobo ea ramatiki ea ramatiki.

Ho etsahalang nakong ea tlhahlobo ea lesole la CCP?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Etsa bonnete ba hore o bolella mofani oa tlhokomelo ea bophelo ka meriana eohle, livithamini le litlatsetso tsa lijo tseo u li nkang. U kanna ua hloka ho emisa ho noa lintho tse ling lihora tse 8 pele ho tlhahlobo ea hau.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Haeba sephetho sa lesole la mmele la CCP se ne se le teng, ho bolela hore masole a mmele ana a ne a fumanwa mading a hao. Sephetho se seng se bolela hore ha ho li-antibodies tsa CCP tse fumanoeng. Moelelo oa liphetho tsena o kanna oa itšetleha ka sephetho sa tlhahlobo ea rheumatoid factor (RF) hammoho le tlhahlobo ea 'mele.

Haeba u na le matšoao a ramatiki, 'me liphetho tsa hau li bontša:

• Li-antibodies tse ntle tsa CCP le RF e ntle, ho kanna ha bolela hore o na le ramatiki ea ramatiki.
• Masole a mmele a matle a CCP le RF e mpe, ho ka bolela hore o maemong a pele a ramatiki kapa o tla e hlahisa nakong e tlang.
• Lisireletsi tse mpe tsa CCP le RF e mpe, ho bolela hore ha o na monyetla oa ho ba le ramatiki ea ramatiki. Mofani oa hau a ka hloka ho etsa liteko tse ling ho thusa ho fumana hore na sesosa sa matšoao a hau ke eng.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea lesole la CCP?

Ho ka ba thata ho fumana ramatiki ea ramatiki, haholo-holo ha e sa tsoa qala. Mofani oa hau a ka odara tlhahlobo e le 'ngoe kapa ho feta ho eketsa lithibela-mafu tsa CCP le tsa RF. Tsena li kenyelletsa x-ray ea manonyeletso a hau le liteko tse latelang tsa mali:

• Sekhahla sa sedimentation sa Erythrocyte (ESR)
• Tlhahlobo ea mokelikeli oa Synovial
• C-protheine e sebetsang
• Sesole sa mmele sa anti-nuclear

Liteko tsena tsa mali li ka bontša matšoao a ho ruruha. Ho ruruha ke mofuta oa karabelo ea sesole sa 'mele. E ka ba letšoao la ramatiki ea ramatiki.

Litšupiso

1. Abdul Wahab A, Mohammad M, Rahman MM, Mohamed Said MS. Anti-cyclic citrullinated peptide antibody ke sesupo se setle sa ho fumanoa ha ramatiki ea ramatiki. Pak J Med Sci. 2013 May-Jun [e qotsitsoeng ka 2020 Feb 12]; 29 (3): 773-77. E fumaneha ho tsoa ho: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809312
2. Koleji ea Amerika ea Rheumatology [Marang-rang]. Atlanta: Koleji ea Amerika ea Rheumatology; c2020. Glossary: ​​cyclic citrullinated peptide (CCP) tlhahlobo ea lesole la 'mele; [e qotsitsoeng ka la 20 Feb 12]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.rheumatology.org/Learning-Center/Glossary/ArticleType/ArticleView/ArticleID/439
3. Motheo oa Ramatiki [Inthanete]. Atlanta: Motheo oa Ramatiki; Ramatiki ea Ramatiki; [e qotsitsoeng ka 2020 Feb 12]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.arthritis.org/diseases/rheumatoid-arthritis
4. Kliniki ea Cleveland [Inthanete]. Cleveland (OH): Kliniki ea Cleveland; c2020. Ramatiki ea Ramatiki: Tlhahlobo le Liteko; [e qotsitsoeng ka 2020 Feb 12]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://my.clevelandclinic.org/health/diseases/4924-rheumatoid-arthritis/diagnosis-and-tests
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6. HSS [Inthanete]. New York: Sepetlele sa Phekolo e Khethehileng; c2019. Ho utloisisa Liteko le Liphetho tsa Lab ea Ramatiki; [e ntlafalitsoeng 2018 Mar 26; e qotsitsoeng ka 2020 Feb 12]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.hss.edu/conditions_understanding-rheumatoid-arthritis-lab-tests-results.asp
7. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001--2020. Li-autoantibodies; [e ntlafalitsoeng 2019 Nov 13; qotsitsoeng 2020 Feb 12]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/autoantibodies
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9. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001--2020. Ho ruruha; [e ntlafalitsoeng 2017 Jul 10; qotsitsoeng 2020 Feb 12]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://labtestsonline.org/glossary/infigueation
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Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.