Teko ea liphatsa tsa lefutso tsa BCR ABL

Litaba

• Teko ea liphatsa tsa lefutso ea BCR-ABL ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea BCR-ABL?
• Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BCR-ABL?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea liphatsa tsa lefutso ea BCR-ABL?
• Litšupiso

Teko ea liphatsa tsa lefutso ea BCR-ABL ke eng?

Tlhahlobo ea liphatsa tsa lefutso ea BCR-ABL e sheba phetoho ea lefutso ho chromosome e itseng.

Li-chromosome ke likarolo tsa lisele tsa hau tse nang le liphatsa tsa hau tsa lefutso. Liphatsa tsa lefutso ke likarolo tsa DNA tse fetisitsoeng ho tsoa ho mme le ntate oa hau. Li na le tlhaiso-leseling e khethollang litšobotsi tsa hau tse ikhethang, joalo ka bophahamo le 'mala oa mahlo.

Ka tloaelo batho ba na le li-chromosome tse 46, ba arotsoe ka lihlopha tse 23 ka seleng ka 'ngoe. E 'ngoe ea li-chromosome ka' ngoe e tsoa ho 'm'ao,' me e 'ngoe e tsoa ho ntate oa hao.

BCR-ABL ke phetoho e entsoeng ka ho kopanya liphatsa tsa lefutso tse peli, tse tsejoang ka hore ke BCR le ABL. Ka linako tse ling e bitsoa fusion gene.

• Lefu la BCR hangata le nomoro ea chromosome ea 22.
• Lefu la ABL hangata le nomoro ea chromosome ea 9.
• Phetoho ea BCR-ABL e etsahala ha likotoana tsa liphatsa tsa lefutso tsa BCR le ABL li tloha ebe li chencha libaka.
• Phetoho e hlaha ho chromosome 22, moo karolo ea chromosome 9 e ikopantseng teng.
• Chromosome e fetohileng ea 22 e bitsoa chromosome ea Philadelphia hobane ke toropo eo bafuputsi ba ileng ba e fumana pele.
• Mofuta oa BCR-ABL ha se mofuta oa phetoho e futsitsoeng ho batsoali ba hau. Ke mofuta oa phetoho ea somatic, ho bolelang hore ha o tsoaloe le eona. U e fumana hamorao bophelong.

Mofuta oa BCR-ABL o hlaha ho bakuli ba nang le mefuta e itseng ea kankere ea mali, mofetše oa masapo le lisele tse tšoeu tsa mali. BCR-ABL e fumanoa hoo e batlang e le bakuli bohle ba nang le mofuta oa kankere ea mali e bitsoang chronic myeloid leukemia (CML). Lebitso le leng la CML ha le fole myelo native kankere ea mali. Mabitso ka bobeli a bua ka lefu le le leng.

Lefu la BCR-ABL le boetse le fumanoa ho bakuli ba bang ba nang le mofuta oa acute lymphoblastic leukemia (ALL) mme e le ka seoelo ho bakuli ba nang le leukemia e matla ea myelogenous (AML).

Meriana e meng ea mofets'e e sebetsa haholoholo ho phekola bakuli ba kankere ea mali ba nang le phetoho ea lefutso ea BCR-ABL. Meriana ena le eona e na le litla-morao tse fokolang ho feta kalafo tse ling tsa mofets'e. Meriana e tšoanang ha e sebetse ho phekola mefuta e fapaneng ea kankere ea mali kapa mefuta e meng ea mofetše.

Mabitso a mang: BCR-ABL1, BCR-ABL1 fusion, chromosome ea Philadelphia

E sebelisetsoa eng?

Hangata tlhahlobo ea BCR-ABL e sebelisoa ho hlahloba kapa ho ntša lefu la kankere ea mali e sa foleng ea myeloid (CML) kapa mofuta o itseng oa leukemia e matla ea lymphoblastic (ALL) e bitsoang Ph-positive ALL. Ph-positive e bolela hore chromosome ea Philadelphia e fumanoe. Teko ha e sebelisetsoe ho fumana mefuta e meng ea kankere ea mali.

Teko e kanna ea sebelisoa ho:

• Bona hore na kalafo ea mofetše e ea sebetsa.
• Bona hore na mokuli o hanne kalafo e itseng. Seo se bolela hore kalafo eo pele e neng e sebetsa e se e sa sebetse.

Hobaneng ha ke hloka tlhahlobo ea liphatsa tsa lefutso ea BCR-ABL?

U kanna oa hloka tlhahlobo ea BCR-ABL haeba u na le matšoao a lefu le sa foleng la myeloid leukemia (CML) kapa Ph-positive acute lymphoblastic leukemia (ALL). Tsena li kenyelletsa:

• Mokhathala
• Feberu
• Ho fokotsa boima ba 'mele
• Ho fufuleloa bosiu (ho fufuleloa haholo ha u robetse)
• Bohloko bo kopaneng kapa ba masapo

Batho ba bang ba nang le CML kapa Ph-positive KAOFELA ha ba na matšoao, kapa matšoao a bonolo haholo, haholo maemong a pele a lefu lena. Kahoo mofani oa hao oa tlhokomelo ea bophelo a ka odara tlhahlobo ena haeba palo e felletseng ea mali kapa tlhahlobo e 'ngoe ea mali e bontšitse sephetho se neng se sa tloaeleha. U lokela hape ho tsebisa mofani oa hau haeba u na le matšoao a u tšoenyang. CML le Ph-positive TSOHLE ho bonolo ho li alafa ha li fumanoa kapele.

U kanna ua hloka tlhahlobo ena haeba u ntse u alafshoa bakeng sa CML kapa Ph-positive ALL. Teko e ka thusa mofani oa hau ho bona hore na kalafo ea hau ea sebetsa.

Ho etsahalang nakong ea tlhahlobo ea liphatsa tsa lefutso tsa BCR-ABL?

Teko ea BCR-ABL hangata ke tlhahlobo ea mali kapa ts'ebetso e bitsoang aspiration ea moko oa masapo le biopsy.

Haeba o etsa tlhahlobo ea mali, setsebi sa tlhokomelo ea bophelo se tla nka sampole ea mali mothapong o letsohong la hao, a sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Haeba u fumana takatso ea moko oa masapo le biopsy, Tsamaiso ea hau e ka kenyelletsa mehato e latelang:

• U tla robala ka lehlakore kapa ka mpeng, ho latela hore na ke lesapo lefe le tla sebelisoa ho etsa liteko. Boholo ba liteko tsa moko oa masapo li nkuoa masapong a noka.
• 'Mele oa hau o tla koaheloa ka lesela, hoo ho bonts'ang feela sebaka se haufi le sebaka sa liteko.
• Sebaka sena se tla hloekisoa ka sethibela-mafu.
• U tla fumana ente ea tharollo ea bohlasoa. E ka hlaba.
• Hang ha sebaka se felloa ke matla, mofani oa tlhokomelo ea bophelo o tla nka sampole. U tla hloka ho bua leshano u khutsitse nakong ea liteko.
  • Bakeng sa takatso ea moko oa masapo, e atisang ho etsoa pele, mofani oa tlhokomelo ea bophelo o tla kenya nale ka lesapo ebe o ntša mokelikeli oa masapo le lisele. U ka utloa bohloko bo hlabang empa bo khuts'oane ha nale e kentsoe.
  • Bakeng sa biopsy ea moko oa masapo, mofani oa tlhokomelo ea bophelo o tla sebelisa sesebelisoa se ikhethileng se kenang masapong ho ntša sampole ea lisele tsa moko oa masapo. U kanna oa utloa khatello sebakeng seo ha sampole e ntse e nkuoa.
• Ho nka metsotso e 10 ho etsa liteko ka bobeli.
• Kamora 'tlhahlobo, mofani oa tlhokomelo ea bophelo o tla koahela sebaka sena ka bandage.
• Rera hore motho e mong au khannele hae, hobane u ka fuoa setulo sa botona pele ho liteko, se ka etsang hore u otsele.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Hangata ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea mali kapa ea mokoallo oa masapo.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Kamora tlhahlobo ea moko oa masapo, o kanna oa ikutloa o le manganga kapa o le bohloko setsing sa ente. Hangata sena sea fela ka matsatsi a 'maloa. Mofani oa hao oa tlhokomelo ea bophelo a ka khothaletsa kapa a fana ka moriana oa bohloko oa ho thusa.

Liphetho li bolelang?

Haeba liphetho tsa hau li bontša hore u na le liphatsa tsa lefutso tsa BCR-ABL, hammoho le lisele tse tšoeu tsa mali tse sa tloaelehang, mohlomong u tla fumanoa u e-na le leukemia e sa foleng ea myeloid (CML) kapa Ph-positive, acute lymphoblastic leukemia (ALL).

Haeba hona joale u alafshoa bakeng sa CML kapa Ph-positive TSOHLE, liphetho tsa hau li ka bonts'a:

• Palo ea BCR-ABL maling a hao kapa mokong oa masapo ea eketseha. Sena se ka bolela hore kalafo ea hau ha e sebetse ebile / kapa u se u le manganga kalafong e itseng.
• Palo ea BCR-ABL maling a hao kapa mokong oa masapo ea fokotseha. Sena se ka bolela hore kalafo ea hau ea sebetsa.
• Palo ea BCR-ABL maling a hao kapa mokong oa masapo ha e ea eketseha kapa ea fokotseha. Sena se ka bolela hore lefu la hau le tsitsitse.

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea liphatsa tsa lefutso ea BCR-ABL?

Kalafo ea lefu le sa foleng la myeloid leukemia (CML) le Ph-positive, acute lymphoblastic leukemia (ALL) e atlehile ho bakuli ba nang le mefuta ena ea leukemia. Ho bohlokoa ho bona mofani oa tlhokomelo ea bophelo ba hau khafetsa ho etsa bonnete ba hore kalafo ea hau e ntse e tsoela pele ho sebetsa. Haeba o hana kalafo, mofani oa hau a ka khothaletsa mefuta e meng ea kalafo ea mofets'e.

Litšupiso

1. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2018. Se Bakang Lefuemia le sa Foleng la Myeloid [le ntlafalitsoeng ka la 2018 Phuptjane 19; e qotsitsoeng 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/chronic-myeloid-leukemia/causes-risks-prevention/what-causes.html
2. Cancer.net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Lefuemia: Myeloid e sa foleng: CML: Selelekela; 2018 Mar [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/introduction
3. Cancer.net [Inthanete]. Alexandria (VA): Mokhatlo oa Amerika oa Clinical Oncology; c2005–2018. Leukemia: Chronic Myeloid: CML: Khetho ea Kalafo; 2018 Mar [e qotsitsoeng ka 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.net/cancer-types/leukemia-chronic-myeloid-cml/treatment-options
4. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. BCR-ABL1 [e ntlafalitsoeng 2017 Dec 4; e qotsitsoeng 2018 Aug 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/bcr-abl1
5. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2018. Leukemia [e ntlafalitsoeng 2018 Jan 18; e qotsitsoeng 2018 Aug 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/conditions/leukemia
6. Leukemia le Lymphoma Society [Marang-rang]. Rye Brook (NY): Leukemia le Lymphoma Society; c2015. Chronic Myeloid Leukemia [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: http://www.lls.org/leukemia/chronic-myeloid-leukemia
7. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. Tlhahiso ea moko oa masapo le litabatabelo: Kakaretso; 2018 Jan 12 [e qotsitsoeng ka 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/tests-procedures/bone-marrow-biopsy/about/pac-20393117
8. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2018. Leukemia e sa foleng ea myelogenous: Kakaretso; 2016 Mots'eanong 26 [e qotsitsoeng 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/chronic-myelogenous-leukemia/symptoms-causes/syc-20352417
9. Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2018. ID ea Teko: BADX: BCR / ABL1, Qualitative, Diagnostic Assay: Clinical and Interpretive [e bontšitsoeng 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/89006
10. Phetolelo ea Merck Manual Consumer [Inthanete]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Tlhahlobo ea Bone Marrow [e bontšitsoeng 2018 Aug 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: http://www.merckmanuals.com/home/blood-disorders/symptoms-and-diagnosis-of-blood-disorders/bone-marrow-examination
11. Phetolelo ea Merck Manual Consumer [Inthanete]. Kenilworth (NJ): Merck & Co., Inc .; c2018. Lefuemia e sa Foleng ea Myelogenous [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.merckmanuals.com/home/blood-disorders/leukemias/chronic-myelogenous-leukemia
12. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Phekolo ea Chronic Myelogenous Leukemia Treatment (PDQ®) -Patient Version [e qotsitsoeng ka 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq
13. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Phekolo e lebisitsoeng ea mofets'e [e qotsitsoeng ka 2018 Aug 1]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
14. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: Phatsa ea lefutso ea BCR-ABL [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene
15. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: BCR-ABL protein fusion [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-protein
16. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bukana ea Tlhatlhobo ea Kankere ea NCI: liphatsa tsa lefutso [tse bontšitsoeng 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
17. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
18. Setsi sa NIH National Human Genome Research [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Bothata ba Chromosome; 2016 Jan 6 [e qotsitsoeng ka 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.genome.gov/11508982
19. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liphatsa tsa lefutso tsa ABL1; 2018 Jul 31 [e bontšitsoeng 2018 Aug 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/gene/ABL1# maemo
20. Oncolink [Inthanete]. Philadelphia: Batlhokomedi ba Yunibesithi ya Pennsylvania; c2018. All About Adult Acute Lymphocytic Leukemia (TSOHLE) [e ntlafalitsoeng 2018 Jan 22; e qotsitsoeng 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.oncolink.org/cancers/leukemia/leukemia-acute-lymphocytic-leukemia-all/all-about-adult-acute-lymphocytic-leukemia-all
21. Oncolink [Inthanete]. Philadelphia: Batlhokomedi ba Yunibesithi ya Pennsylvania; c2018. All About Chronic Myeloid Leukemia (CML) [e ntlafalitsoeng 2017 Oct 11; e qotsitsoeng 2018 Aug 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.oncolink.org/cancers/leukemia/chronic-myelogenous-leukemia-cml/all-about-chronic-myeloid-leukemia-cml

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.