Teko ea Alpha-1 Antitrypsin

Litaba

• Teko ea alpha-1 antitrypsin (AAT) ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka tlhahlobo ea AAT?
• Ho etsahalang nakong ea tlhahlobo ea AAT?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa tlhahlobo?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea AAT?
• Litšupiso

Teko ea alpha-1 antitrypsin (AAT) ke eng?

Teko ena e lekanya palo ea alpha-1 antitrypsin (AAT) maling. AAT ke protheine e entsoeng sebeteng. E thusa ho sireletsa matšoafo a hao tšenyehong le maloetseng, joalo ka emphysema le lefu le sa foleng la pulmonary pulmonary (COPD).

AAT e entsoe ke liphatsa tse ling tsa 'mele oa hau. Liphatsa tsa lefutso ke likarolo tsa motheo tsa lefutso tse fetisitsoeng ke batsoali ba hau. Li na le tlhaiso-leseling e khethollang litšobotsi tsa hau tse ikhethang, joalo ka bophahamo le 'mala oa mahlo. Motho e mong le e mong o futsa likopi tse peli tsa lefutso tse etsang AAT, e le 'ngoe ho ntate oa bona mme e' ngoe e tsoa ho mme oa bona. Haeba ho na le phetoho (phetoho) ho e le 'ngoe kapa likopi tse peli tsa lefutso lena,' mele oa hau o tla etsa AAT kapa AAT e tlase e sa sebetseng ka nepo.

• Haeba u na le likopi tse peli tse fetotsoeng tsa lefutso, ho bolela hore o na le boemo bo bitsoang khaello ea AAT. Batho ba nang le bothata bona ba na le kotsi e kholo ea ho tšoaroa ke lefu la matšoafo kapa tšenyo ea sebete pele ba le lilemo li 45.
• Haeba u na le lefutso le le leng la AAT, o kanna oa ba le lipalo tse tlase ho feta tse tloaelehileng tsa AAT, empa matšoao a bonolo a lefu kapa ha a eo. Batho ba nang le lefutso le le leng le fetotsoeng ke bajari ba khaello ea AAT. Sena se bolela hore ha o na boemo boo, empa o ka fetisetsa lefutso le fetotsoeng ho bana ba hau.

Teko ea AAT e ka thusa ho bonts'a haeba u na le phetoho ea lefutso e u behang kotsing ea mafu.

Mabitso a mang: A1AT, AAT, alpha-1-antiprotease khaello, α1-antitrypsin

E sebelisetsoa eng?

Hangata ho sebelisoa teko ea AAT ho thusa ho fumana khaello ea AAT ho batho ba hlahisang lefu la matšoafo ba sa le banyenyane (lilemo tse 45 kapa tlase) mme ba se na mabaka a mang a kotsi a kang ho tsuba.

Teko e kanna ea sebelisoa ho fumana mofuta o sa tloaelehang oa lefu la sebete ho masea.

Hobaneng ha ke hloka tlhahlobo ea AAT?

U kanna oa hloka tlhahlobo ea AAT haeba u le ka tlase ho lilemo tse 45, ha u tsube, 'me u na le matšoao a lefu la matšoafo, ho kenyelletsa:

• Ho honotha
• Phefumoloho e khutšoanyane
• Ho khohlela ho sa foleng
• Ho potlaka ho feta ho otla ha pelo ho tloaelehileng ha u ema
• Mathata a pono
• Sefuba se sa arabeleng hantle kalafong

U ka fumana teko ena haeba u na le nalane ea lelapa ea khaello ea AAT.

Ho haella ha AAT ho masea hangata ho ama sebete. Kahoo ngoana oa hau a ka hloka tlhahlobo ea AAT haeba mofani oa hae oa tlhokomelo ea bophelo a fumana matšoao a lefu la sebete. Tsena li kenyelletsa:

• Jaundice, mosehla oa letlalo le mahlo o tšoarellang nako e fetang beke kapa tse peli
• Spleen e atolositsoeng
• Ho hlohlona khafetsa

Ho etsahalang nakong ea tlhahlobo ea AAT?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ha o hloke litokisetso tse khethehileng bakeng sa tlhahlobo ea AAT.

Na ho na le likotsi tsa tlhahlobo?

Ho na le kotsi e fokolang haholo 'meleng tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Haeba liphetho tsa hau li bonts'a palo e tlase ho feta e tloaelehileng ea AAT, mohlomong ho bolela hore o na le liphatsa tsa lefutso tsa AAT e le 'ngoe kapa tse peli. Ha boemo bo le tlase, ho na le monyetla oa hore o na le liphatsa tsa lefutso tse peli tse fetotsoeng le khaello ea AAT.

Haeba u fumanoa u na le khaello ea AAT, u ka nka mehato ea ho fokotsa menyetla ea lefu. Tsena li kenyelletsa:

• Ho se tsube. Haeba u tsuba, khaotsa ho tsuba. Haeba u sa tsube, u se ke ua qala. Ho tsuba ke eona ntho e ka sehloohong e bakang lefu la matšoafo le sokelang bophelo ho batho ba nang le khaello ea AAT.
• Ho latela phepo e nepahetseng
• Ho ikoetlisa kamehla
• Ho bona mofani oa tlhokomelo ea bophelo khafetsa
• Ho noa meriana ho latela taelo ea mofani oa hau

Haeba u na le lipotso mabapi le liphetho tsa hau, bua le mofani oa tlhokomelo ea bophelo.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea AAT?

Pele o lumela ho etsa liteko, ho ka thusa ho bua le moeletsi oa liphatsa tsa lefutso. Moeletsi oa liphatsa tsa lefutso ke setsebi se koetlisitsoeng ka ho khetheha liphatseng tsa lefutso le liteko tsa lefutso. Moeletsi a ka u thusa ho utloisisa likotsi le melemo ea tlhahlobo. Haeba u lekile, moeletsi a ka u thusa ho utloisisa sephetho le ho fana ka tlhaiso-leseling ka boemo boo, ho kenyeletsoa le kotsi ea ho fetisetsa lefu lena ho bana ba hau.

Litšupiso

1. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Alfa-1 Antitrypsin; [e ntlafalitsoeng 2019 Jun 7; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/alpha-1-antitrypsin
2. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Jaundice; [e ntlafalitsoeng 2018 Feb 2; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://labtestsonline.org/conditions/jaundice
3. Phetolelo ea Merck Manual Consumer [Inthanete]. Kenilworth (NJ): Merck & Co Inc .; c2019. Khaello ea Alpha-1 Antitrypsin; [e ntlafalitsoeng 2018 Nov; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho:
4. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Khaello ea Alpha-1 Antitrypsin; [e qotsitsoeng ka 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/alpha-1-antitrypsin-deficiency
5. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng ka 2019 Oct 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
6. NIH Laeborari ea Naha ea Bongaka ea NIH U.S. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Gene ke eng ?; 2019 Oct 1 [e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://ghr.nlm.nih.gov/primer/basics/gene
7. Bophelo ba UF: Univesithi ea Florida Health [Marang-rang]. Gainesville (FL): Univesithi ea Florida Health; c2019. Alpha-1 tlhahlobo ea mali ea antitrypsin: Kakaretso; [e ntlafalitsoeng 2019 Oct 1; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://ufhealth.org/alpha-1-antitrypsin-blood-test
8. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2019. Health Encyclopedia: Alpha-1 Antitrypsin; [e qotsitsoeng ka 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=alpha_1_antitrypsin
9. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Alpha-1 Antitrypsin Teko ea Liphatsa tsa lefutso: Ho haelloa ke Alpha-1 Antitrypsin ke eng ?; [e ntlafalitsoeng 2018 Sep 5; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html
10. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Alpha-1 Antitrypsin Teko ea Liphatsa tsa lefutso: Tlhabollo ea liphatsa tsa lefutso ke eng ?; [e ntlafalitsoeng 2018 Sep 5; e qotsitsoeng 2019 Oct 1]; [tse ka bang li-skrini tse 7]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#tv8548
11. Bophelo ba UW [Marang-rang]. Madison (WI): Univesithi ea Wisconsin Lipetlele le Bolaoli ba Litleliniki; c2019. Tlhatlhobo ea liphatsa tsa lefutso ea Alpha-1 Antitrypsin: Hobaneng ke sa Tekoe ?; [e ntlafalitsoeng 2018 Sep 5; e qotsitsoeng 2019 Oct 1]; [li-skrini tse ka bang 6]. E fumaneha ho tsoa ho: https://www.uwhealth.org/health/topic/special/alpha-1-antitrypsin-deficiency-genetic-testing/uf6753.html#uf6790

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.