Teko ea moroto oa Cortisol

Teko ea moroto oa cortisol e lekanya boemo ba cortisol ka morong. Cortisol ke hormone ea glucocorticoid (steroid) e hlahisoang ke tšoelesa ea adrenal.

Cortisol e ka lekanyetsoa hape ka ho hlahloba mali kapa mathe.

Ho hlokahala sampole ea lihora tse 24. U tla hloka ho bokella moroto oa hau ho feta lihora tse 24 ka setshelong se fanoeng ke laboratori. Mofani oa hao oa tlhokomelo ea bophelo o tla u joetsa hore na u ka etsa sena joang. Latela litaelo hantle.

Hobane tlhahiso ea cortisol ke tšoelesa ea adrenal e ka fapana, tlhahlobo e kanna ea hloka ho etsoa makhetlo a mararo kapa ho feta ho fumana setšoantšo se nepahetseng sa tlhahiso ea cortisol.

U ka kopuoa hore u se ke ua ikoetlisa ka matla letsatsi pele ho tlhahlobo.

U kanna oa bolelloa hore u emise ho noa meriana ka nakoana e ka amang tlhahlobo, ho kenyelletsa:

• Lithethefatsi tse khahlanong le ho inkela
• Estrogen
• Li-glucocorticoids tse entsoeng ke batho, tse kang hydrocortisone, prednisone le prednisolone
• Androgens

Teko e kenyelletsa feela ho ntša metsi ka mokhoa o tloaelehileng. Ha ho na bothata.

Teko e etsoa ho lekola tlhahiso ea cortisol e eketsehang kapa e fokotsehileng. Cortisol ke hormone ea glucocorticoid (steroid) e tsoang ho adrenal gland ho arabela adrenocorticotropic hormone (ACTH). Ena ke hormone e tsoang lethong la pituitary bokong. Cortisol e ama litsamaiso tse ngata tse fapaneng tsa 'mele. E bapala karolo ho:

• Khōlo ea masapo
• Ho laola khatello ea mali
• Ts'ebetso ea immune system
• Metabolism ea mafura, lik'habohaedreite le protheine
• Ts'ebetso ea methapo e sebetsa
• Karabo ea khatello ea maikutlo

Maloetse a fapaneng, joalo ka Cushing syndrome le lefu la Addison, a ka lebisa ho hlahiseng cortisol e ngata haholo kapa e nyane haholo. Ho lekanya boemo ba moroto oa cortisol ho ka thusa ho fumana maemo ana.

Mefuta e tloaelehileng ke 4 ho isa ho 40 mcg / lihora tse 24 kapa 11 ho isa ho 110 nmol / letsatsi.

Mekhahlelo e tloaelehileng ea boleng e ka fapana hanyane hara lilaboratori tse fapaneng. Li-lab tse ling li sebelisa litekanyo tse fapaneng kapa li ka leka mefuta e fapaneng. Bua le mofani oa hau ka moelelo oa sephetho sa hau sa liteko.

Boemo bo phahameng ho feta bo tloaelehileng bo ka supa:

• Cushing lefu, moo tšoelesa ea pituitary e etsang ACTH e ngata haholo ka lebaka la kholo e fetelletseng ea tšoelesa ea "pituitary" kapa "" "" "tumor" ho "pituitary gland".
• Ectopic Cushing syndrome, moo hlahala e ka ntle ho litšoelesa tsa pituitary kapa adrenal e etsang ACTH e ngata haholo
• Ho tepella maikutlo ho matla
• Hlahala ea adrenal gland e hlahisang cortisol e ngata haholo
• Ho imeloa kelellong haholo
• Mathata a sa tloaelehang a liphatsa tsa lefutso

Boemo bo tlase ho feta bo tloaelehileng bo ka supa:

• Boloetse ba Addison moo litšoelesa tsa adrenal li sa hlahiseng cortisol e lekaneng
• Hypopituitarism moo tšoelesa ea pituitary e sa supeng tšoelesa ea adrenal ho hlahisa cortisol e lekaneng
• Phekolo ea ts'ebetso e tloaelehileng ea pituitary kapa adrenal ke meriana ea glucocorticoid e kenyeletsang lipilisi, litlolo tsa letlalo, mahlo a mahlo, li-inhalers, liente tse kopanetsoeng, chemotherapy

Ha ho na likotsi ka tlhahlobo ena.

Cortisol (UFC) ea lihora tse 24 ea ho ntša metsi

• Mosali pampitšana ea mosese
• Mokhoa oa banna oa ho ntša metsi

CC ea Chernecky, Berger BJ. Cortisol - moroto. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 389-390.

Stewart PM, Newell-Price JDC. Karolo ea adrenal cortex. Ka: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, bahlophisi. Buka ea Williams ea Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016: khaolo ea 15.