Antigen ea HLA-B27

HLA-B27 ke teko ea mali ho batla protheine e fumanehang holim'a lisele tse tšoeu tsa mali. Protheine e bitsoa human leukocyte antigen B27 (HLA-B27).

Li-antigen tsa batho tsa leukocyte (HLAs) ke liprotheine tse thusang sesole sa 'mele ho tseba phapang lipakeng tsa lisele tsa sona le lintho tse tsoang kantle ho naha tse kotsi. Li entsoe ka litaelo tsa liphatsa tsa lefutso.

Ho hlokahala sampole ea mali. Boholo ba nako, mali a huloa mothapong o kahare ho setsoe kapa ka morao ho letsoho.

Maemong a mangata, ha ho hlokahale mehato e ikhethang ho itokisetsa tlhahlobo.

Ha nale e kentsoe ho hula mali, o kanna oa utloa bohloko bo mahareng, kapa bohloko feela kapa ho hlaba. Kamora moo, ho kanna ha ba le ho tsitsipana.

Mofani oa hao oa tlhokomelo ea bophelo a ka laela tlhahlobo ena ho thusa ho tseba sesosa sa bohloko bo kopaneng, ho satalla kapa ho ruruha. Teko e kanna ea etsoa hammoho le liteko tse ling, ho kenyelletsa:

• C-protheine e sebetsang
• Sekhahla sa sedimentation sa Erythrocyte (ESR)
• Lebaka la ramatiki
• Li-X-ray

Ho hlahlojoa ha HLA ho boetse ho sebelisetsoa ho nyalanya lisele tse fanoeng le lisele tsa motho tse kenngoang setho. Mohlala, e ka etsoa ha motho a hloka ho fetisetsoa liphio kapa ho fetisoa ha moko oa masapo.

Sephetho se tloaelehileng (se fosahetseng) se bolela hore HLA-B27 ha e eo.

Teko e nepahetseng e bolela hore HLA-B27 e teng. E fana ka maikutlo a kotsi e fetang ea karolelano ea ho nts'etsapele kapa ho ba le mathata a itseng a boits'ireletso. Bothata ba ho itšireletsa mafung ke boemo bo hlahang ha sesole sa 'mele se hlasela le ho senya lisele tse phetseng hantle ka' mele.

Phello e ntle e ka thusa mofani oa hau ho hlahloba mofuta oa ramatiki o bitsoang spondyloarthritis. Mofuta ona oa ramatiki o kenyelletsa mathata a latelang:

• Ankylosing spondylitis
• Ramatiki e amanang le lefu la Crohn kapa ulcerative colitis
• Psoriatic ramatiki (ramatiki e amanang le psoriasis)
• Ho itšireletsa mafung
• Sacroiliitis (ho ruruha ha kopane ea sacroiliac)
• Uveitis

Haeba u na le matšoao kapa matšoao a spondyloarthritis, tlhahlobo e ntle ea HLA-B27 e ka thusa ho netefatsa tlhahlobo. Leha ho le joalo, HLA-B27 e fumanoa ho batho ba bang ba tloaelehileng mme ha se kamehla ho bolelang hore o na le lefu.

Likotsi tsa ho huloa mali li nyane, empa li ka kenyelletsa:

• Ho tsoa mali a mangata
• Ho akheha kapa ho ikutloa o le hlooho e boima
• Hematoma (mali a bokellanang ka tlasa letlalo)
• Tšoaetso (kotsi e nyane neng kapa neng ha letlalo le robehile)

Antigen ea batho leukocyte antigen B27; Ankylosing spondylitis-HLA; Psoriatic ramatiki-HLA; Phekolo ea ramatiki-HLA

• Teko ea mali

CC ea Chernecky, Berger BJ. Leukocyte Antigen ea Batho (HLA) B-27 - mali. Ka: Chernecky CC, Berger BJ, bahlophisi. Liteko tsa Laboraro le Mekhoa ea Tlhatlhobo. La 6th. St Louis, MO: Elsevier Saunders; 2013: 654-655.

Fagoaga KAPA. Antigen ea leukocyte ea batho: kholo e kholo ea nalane ea motho. Ka: McPherson RA, Pincus MR, bahlophisi. Henry's Clinical Diagnosis le Tsamaiso ka Mekhoa ea Laboraro. La bo23 la ed. St Louis, MO: Elsevier; 2017: khaolo ea 49.

Inman RD. Li-spondyloarthropathies. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 265.

McPherson RA, Massey HD. Kakaretso ea sesole sa 'mele le mathata a immunologic. Ka: McPherson RA, Pincus MR, bahlophisi. Henry's Clinical Diagnosis le Tsamaiso ka Mekhoa ea Laboraro. La bo23 la ed. St Louis, MO: Elsevier; 2017: khaolo ea 43.

Hlahisa JD. Spondyloarthritis. Ho: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Ba fokolang AJ, Weyand CM, eds. Clinical Immunology: Melao-motheo le Tloaelo. La 5th. Philadelphia, PA: Elsevier; 2019: khaolo ea 57.