Kankere ea kankere ea adrenocortical

Adrenocortical carcinoma (ACC) ke mofetše oa litšoelesa tsa adrenal. Litšoelesa tsa adrenal ke litšoelesa tse peli tse bopehileng joaloka likhutlo li tharo. Tšoelesa e le 'ngoe e kaholimo ho liphio ka leng.

ACC e atile haholo ho bana ba ka tlase ho lilemo tse 5 le batho ba baholo lilemong tsa bona tsa 40 le 50.

Boemo bo kanna ba amahanngoa le lefu la mofets'e le fetisoang ke malapa (a futsitsoeng). Banna le basali ba ka ba le hlahala ena.

ACC e ka hlahisa lihormone cortisol, aldosterone, estrogen, kapa testosterone, hammoho le lihormone tse ling. Ho basali hlahala hangata e ntša lihomone tsena, tse ka lebisang ho litšobotsi tsa banna.

ACC ha e fumanehe hangata. Lebaka ha le tsejoe.

Matšoao a cortisol e eketsehileng kapa lihomone tse ling tsa adrenal gland li ka kenyelletsa:

• Mokokotlo o mafura, o chitja ka mokokotlong ka tlasa molala (buffalo hump)
• Sefahleho se sefahleho se chitja se nang le marama a sefahleho (sefahleho sa khoeli)
• Botenya
• Khōlo e sa tsitsang (seemo se sekhuts'oane)
• Virilization - ponahalo ea litšobotsi tsa banna, ho kenyeletsoa moriri o eketsehileng oa 'mele (haholo sefahlehong), moriri oa pubic, makhopho, ho teba ha lentsoe, le clitoris e atolositsoeng (basali)

Matšoao a aldosterone e eketsehileng a ts'oana le matšoao a potasiamo e tlase, mme a kenyeletsa:

• Maqhubu a mesifa
• Bofokoli
• Bohloko bo ka mpeng

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele mme a botse ka matšoao a hau.

Ho tla etsoa liteko tsa mali ho lekola maemo a lihormone:

• Boemo ba ACTH bo tla ba tlase.
• Boemo ba Aldosterone bo tla ba holimo.
• Boemo ba Cortisol bo tla ba holimo.
• Potassium e tla ba tlase.
• Lihomone tsa banna kapa tsa basali li ka ba holimo ka mokhoa o sa tloaelehang.

Ho nahana ka liteko tsa mpa ho ka kenyelletsa:

• Ultrasound
• CT scan
• MRI
• Scan ea PET

Kalafo ea mantlha ke ho buuoa ho tlosa hlahala. ACC e kanna ea se ntlafale ka chemotherapy. Ho ka fanoa ka meriana ho fokotsa tlhahiso ea cortisol, e bakang matšoao a mangata.

Phello e latela hore na tlhahlobo e etsoa kapele hakae le hore na hlahala e hasane (metastasized). Lihlahala tse jalang hangata li lebisa lefung pele ho selemo se le seng ho isa ho tse tharo.

Hlahala e ka namela sebeteng, masapong, matšoafong kapa libakeng tse ling.

Bitsa mofani oa hau haeba uena kapa ngoana oa hau a e-na le matšoao a ACC, Cushing syndrome, kapa a sa khone ho hola.

Hlahala - adrenal; ACC - adrenal

• Litšoelesa tsa endocrine
• Adrenal metastases - CT scan
• Adrenal Tumor - CT

Allolio B, Fassnacht M. Adrenocortical carcinoma. Ka: Jameson JL, De Groot LJ, oa Kretser DM, et al, eds. Endocrinology: Batho ba baholo le bana. La 7th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 107.

Webosaete ea National Cancer Institute. Kalafo ea Adrenocortical carcinoma (Batho ba baholo) (PDQ) - mofuta oa litsebi tsa bophelo bo botle. www.cancer.gov/types/adrenocortical/hp/adrenocortical- kalafo-pdq. E ntlafalitsoe ka la 13 Pulungoana, 2019. E fihlile ka la 14 Mphalane 2020.