Ho haella ha Prothrombin

Ho haella ha Prothrombin ke lefu le bakoang ke khaello ea protheine maling e bitsoang prothrombin. E lebisa mathateng ka ho hoama ha mali (coagulation). Prothrombin e boetse e tsejoa e le ntlha II (ntlha ea bobeli).

Ha o tsoa mali, letoto la liketso li etsahala 'meleng o thusang ho hlama ha mali. Ts'ebetso ena e bitsoa coagulation cascade. E kenyelletsa liprotheine tse khethehileng tse bitsoang ho koala kapa ho koala. U ka ba le monyetla o moholo oa ho tsoa mali a mangata haeba e le 'ngoe kapa tse ling tsa lintlha tsena li le sieo kapa li sa sebetse joalo ka ha li lokela.

Prothrombin, kapa factor II, ke e 'ngoe ea li-coagulation factor. Ho haella ha Prothrombin ho mathela malapeng (ho futsitsoe) mme ho sa tloaelehang haholo. Batsoali ka bobeli ba tlameha ho ba le lefutso ho fetisetsa lefu lena ho bana ba bona. Nalane ea lelapa ea lefu la ho tsoa mali e ka ba sesosa sa kotsi.

Ho haella ha Prothrombin ho ka bakoa ke boemo bo bong kapa ts'ebeliso ea meriana e itseng. Sena se bitsoa khaello ea prothrombin. E ka bakoa ke:

• Ho haella ha vithamine K (masea a mang a tsoaloa a na le khaello ea vithamine K)
• Lefu le matla la sebete
• Ts'ebeliso ea meriana e thibelang ho hoama (li-anticoagulants tse kang warfarin)

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Ho tsoa mali ka tsela e sa tloaelehang kamora ho beleha
• Ho tsoa mali haholo khoeling
• Ho tsoa mali kamora ho buuoa
• Ho tsoa mali ka mora ts'itiso
• Ho rohakana habonolo
• Madi a nkoang madi a sa emeng habonolo
• Mokokotlo o tsoa mali kamora ho hlaha

Liteko tse ka etsoang li kenyelletsa:

• Ntlha ea bobeli ea liteko
• Nako ea karoloana ea thromboplastin
• Nako ea Prothrombin (PT)
• Ho kopanya thuto (teko e khethehileng ea PTT ho netefatsa khaello ea prothrombin)

Ts'ollo ea mali e ka laoloa ka ho fumana tšoaetso ea mali (IV) ea mali kapa ho kopanya lintho tse hoamisang mali. Haeba u haelloa ke vithamine K, u ka noa vithamine ena ka molomo, ka liente tse tlas'a letlalo, kapa ka methapo (ka methapo).

Haeba u na le bothata bona ba ho tsoa mali, etsa bonnete ba ho:

• Bolella bafani ba hao ba tlhokomelo ea bophelo pele u etsa mokhoa oa mofuta o fe kapa o fe, ho kenyeletsoa le ho buuoa le mosebetsi oa meno.
• Bolella litho tsa lelapa la hau hobane ba kanna ba ba le bothata bo tšoanang empa ha ba tsebe hona joale.

Lisebelisoa tsena li ka fana ka tlhaiso-leseling e batsi ka khaello ea Ntlha ea VII:

• Setsi sa Naha sa Haemophilia: Mefokolo e Meng ea Lintlha - www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficience
• Setsi sa Boitsebiso ba Mafu a Rare le a Rare - rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Phello e ntle ka kalafo e nepahetseng.

Ho haelloa ke prothrombin ke lefu la bophelo bohle.

Pono ea khaello ea prothrombin e ipapisitse le sesosa. Haeba e bakoa ke lefu la sebete, sephetho se latela hore na lefu la sebete sa hau le ka phekoloa joang. Ho noa li-supplement tsa vithamine K ho tla sebetsana le khaello ea vithamine K.

Ho tsoa mali a mangata lithong ho ka etsahala.

Fumana kalafo ea tšohanyetso hang-hang haeba u na le tahlehelo ea mali e sa hlaloseheng kapa e telele, kapa haeba u sa khone ho laola ho tsoa mali.

Ha ho na thibelo e tsebahalang ea khaello ea prothrombin e futsitsoeng. Ha khaello ea vithamine K e le sesosa, ho sebelisa vithamine K ho ka thusa.

Hypoprothrombinemia; Khaello ea Ntlha ea II; Dysprothrombinemia

• Ho thehoa ha mali
• Ho koala mali

Gailani D, Wheeler AP, Neff AT. Mathata a sa tloaelehang a li-coagulation. Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 137.

Holo ea JE. Hemostasis le coagulation ea mali. Ka: Holo ea JE, ed. Buka ea Guyton le Hall ea Physiology ea Bongaka. 13th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 37.

Ragni MV. Mathata a hemorrhagic: ho haelloa ke lebaka la coagulation. Ka: Goldman L, Schafer AI, li-eds. Phekolo ea Goldman-Cecil. La 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 174.