Cryoglobulinemia

Cryoglobulinemia ke boteng ba liprotheine tse sa tloaelehang maling. Liprotheine tsena li hola maemong a batang a batang.

Li-cryoglobulins ke lithibela-mafu. Ha ho e-so tsejoe hore na hobaneng ba tiea kapa ba tšoana le gel maemong a batang haholo laboratoring. 'Meleng, li-antibodies tsena li ka theha li-immune complexes tse ka bakang ho ruruha le ho thibela methapo ea mali. Sena se bitsoa cryoglobulinemic vasculitis. Sena se ka baka mathata ho tloha ho makhopho a letlalo ho ea ho hloleha ha liphio.

Cryoglobulinemia ke karolo ea sehlopha sa mafu a bakang tšenyo le ho ruruha ha methapo ea mali ho pholletsa le 'mele (vasculitis). Ho na le mefuta e meraro e ka sehloohong ea boemo bona. Li hlophisitsoe ka mofuta oa lesole la mmele le hlahisoang:

• Tlanya I
• Mofuta oa II
• Mofuta oa III

Mefuta ea II le III e boetse e bitsoa cryoglobulinemia e tsoakaneng.

Mofuta oa I cryoglobulinemia hangata o amana le mofetše oa mali kapa boits'ireletso ba mmele.

Mefuta ea II le III hangata e fumanoa ho batho ba nang le boemo ba nako e telele (bo sa foleng) ba ho ruruha, joalo ka lefu la autoimmune kapa hepatitis C. Batho ba bangata ba nang le mofuta oa mofuta oa II oa cryoglobulinemia ba na le ts'oaetso e sa foleng ea lefu la sebete la mofuta oa C.

Maemo a mang a ka amanang le cryoglobulinemia a kenyelletsa:

• Lefuemia
• Myeloma e mengata
• Macroglobulinemia ea mantlha
• Ramatiki ea ramatiki
• Sesebelisoa sa lupus erythematosus

Matšoao a tla fapana, ho latela mofuta oa bothata boo u nang le bona le litho tse amehang. Matšoao a ka kenyelletsa:

• Mathata a phefumolohang
• Mokhathala
• Glomerulonephritis
• Bohloko bo kopaneng
• Bohloko ba mesifa
• Morero
• Ketsahalo ea Raynaud
• Lefu la letlalo
• Liso tsa letlalo

Mofani oa tlhokomelo ea bophelo o tla etsa tlhahlobo ea 'mele. U tla hlahlojoa hore na u na le matšoao a ho ruruha ha sebete le spleen.

Liteko tsa cryoglobulinemia li kenyelletsa:

• Palo e felletseng ea mali (CBC).
• Tlatsa tlhahlobo - lipalo li tla ba tlase.
• Teko ea Cryoglobulin - e kanna ea bontša boteng ba li-cryoglobulin. (Ena ke ts'ebetso e rarahaneng ea laboratori e kenyang mehato e mengata. Ho bohlokoa hore laboraka e etsang tlhahlobo e tsebe mokhoa ona.)
• Liteko tsa ts'ebetso ea sebete - li ka ba holimo haeba lefu la hepatitis C le le teng.
• Rheumatoid factor - e ntle ho mefuta ea II le III.
• Letlalo biopsy - ka bontša ho ruruha ka methapo ea mali, vasculitis.
• Protheine electrophoresis - mali - e ka bonts'a protheine e sa tloaelehang ea antibody.
• Urinalysis - e ka bonts'a mali ka morong haeba liphio li amehile.

Liteko tse ling li ka kenyelletsa:

• Angiogram
• X-ray sefubeng
• ESR
• Teko ea Hepatitis C
• Liteko tsa ho khanna methapo, haeba motho a na le bofokoli matsohong kapa maotong

MOTSOALLE OA CRYOGLOBULINEMIA (MEFUTA II LE III)

Mefuta e bonolo kapa e itekanetseng ea cryoglobulinemia e ka phekoloa hangata ka ho nka mehato ea ho sebetsana le sesosa.

Meriana ea hajoale e sebetsang ka kotloloho bakeng sa hepatitis C e felisa vaerase ho batho bohle. Ha lefu la hepatitis C le fela, li-cryoglobulin li tla nyamela hoo e ka bang halofo ea batho bohle likhoeling tse 12 tse tlang. Mofani oa hau o tla tsoelapele ho lekola li-cryoglobulins kamora kalafo.

Cryoglobulinemia vasculitis e matla e kenyelletsa litho tsa bohlokoa kapa libaka tse kholo tsa letlalo. E alafshoa ka li-corticosteroids le meriana e meng e hatellang sesole sa 'mele.

• Rituximab ke sethethefatsi se sebetsang 'me se na le likotsi tse fokolang ho feta meriana e meng.
• Cyclophosphamide e sebelisoa maemong a sokelang bophelo moo rituximab e sa sebetseng kapa e sa fumaneheng. Meriana ena e ne e sebelisoa khafetsa nakong e fetileng.
• Kalafo e bitsoang plasmapheresis le eona ea sebelisoa. Ts'ebetsong ena, lero la mali le ntšoa ka har'a mali 'me ho tlosoa liprotheine tse sa tloaelehang tsa' mele tsa cryoglobulin. Lero la mali le nkeloa sebaka ke lero la mali, protheine kapa plasma.

Mofuta I CRYOGLOBULINEMIA

Boloetse bona bo bakoa ke mofetše oa mali kapa boits'ireletso ba mmele joalo ka myeloma e mengata. Kalafo e lebisitsoe ho lisele tse sa tloaelehang tsa mofetše tse hlahisang cryoglobulin.

Boholo ba nako, cryoglobulinemia e kopaneng ha e lebise lefung. Ponahalo e ka ba mpe haeba liphio li amehile.

Mathata a kenyelletsa:

• Ho tsoa mali ka har'a tšilo ea lijo (ka seoelo)
• Lefu la pelo (seoelo)
• Tšoaetso ea liso
• Ho hloleha ha liphio
• Ho hloleha ha sebete
• Lefu la letlalo
• Lefu

Bitsa mofani oa hau haeba:

• U hlahisa matšoao a cryoglobulinemia.
• U na le lefu la sebete la mofuta oa C 'me u hlahisa matšoao a cryoglobulinemia.
• U na le cryoglobulinemia mme u ba le matšoao a macha kapa a mpefalang.

Ha ho na thibelo e tsebahalang ea boemo bona.

• Ho lula hole le mocheso o batang ho ka thibela matšoao a mang.
• Ho etsa liteko le kalafo ea ts'oaetso ea hepatitis C ho tla fokotsa kotsi ea hau.

• Cryoglobulinemia ea menoana
• Cryoglobulinemia - menoana
• Lisele tsa mali

Patterson ER, Winters JL. Hemapheresis. Ka: McPherson RA, Pincus MR, bahlophisi. Henry's Clinical Diagnosis le Tsamaiso ka Mekhoa ea Laboraro. La bo23 la ed. St Louis, MO: Elsevier; 2017: khaolo ea 37.

Roccatello D, Saadoun D, ​​Ramos-Casals M, le al. Cryoglobulinaemia. Lithuto tsa Nat Rev Dis Primers. 2018; 4 (1): 11. PMID: 30072738 pubmed.ncbi.nlm.nih.gov/30072738/.

Lejoe JH. Sekepe se senyenyane sa methapo ea mmele se rarahaneng. Ka: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, bahlophisi. Kelley le Firestein's Bookbook ea Rheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: khaolo ea 91.