Amyloidosis ea mantlha

Amyloidosis ea mantlha ke lefu le sa tloaelehang leo ho lona liprotheine tse sa tloaelehang li hahang ka har'a lisele le litho. Likhohlopo tsa liprotheine tse sa tloaelehang li bitsoa li-deposits tsa amyloid.

Lebaka la amyloidosis ea mantlha ha le utloisisoe hantle. Liphatsa tsa lefutso li ka bapala karolo.

Boemo bona bo amana le tlhahiso e sa tloaelehang le e fetelletseng ea liprotheine. Ho hlaha ha liprotheine tse sa tloaelehang lithong tse ling. Sena se thatafalletsa litho ho sebetsa hantle.

Amyloidosis ea mantlha e ka lebisa ho maemo a kenyeletsang:

• Lefu la Carpal tunnel
• Tšenyo ea mesifa ea pelo (cardiomyopathy) e lebisang ho ho hloleha ha pelo
• Malabsorption ea mala
• Ho ruruha ha sebete le ho se sebetse hantle
• Ho hloleha ha liphio
• Nephrotic syndrome (sehlopha sa matšoao a kenyeletsang protheine ka har'a moroto, liprotheine tse tlase tsa mali maling, maemo a phahameng a k'holeseterole, maemo a phahameng a triglyceride le ho ruruha 'meleng oohle)
• Mathata a methapo (neuropathy)
• Orthostatic hypotension (theoha khatello ea mali ha u ema)

Matšoao a ipapisitse le litho tse amehileng. Lefu lena le ka ama litho tse ngata tsa mmele le lisele, ho kenyelletsa leleme, mala, masapo le mesifa e boreleli, methapo, letlalo, methapo, pelo, sebete, spene le liphio.

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Pina e sa tloaelehang ea pelo
• Mokhathala
• Boikutlo ba matsoho kapa maoto
• Phefumoloho e khutšoanyane
• Letlalo lea fetoha
• Ho metsa mathata
• Ho ruruha matsohong le maotong
• Leleme le ruruhileng
• Tšoaro e fokolang ea letsoho
• Ho fokotsa boima ba 'mele kapa ho nona

Matšoao a mang a ka hlahang ka lefu lena:

• Ho fokotsa tlhahiso ea moroto
• Letšollo
• Ho honotha kapa ho fetola lentsoe
• Bohloko bo kopaneng
• Bofokoli

Mofani oa tlhokomelo ea bophelo o tla u hlahloba. U tla botsoa ka nalane ea hau ea bongaka le matšoao a hau. Tlhahlobo ea 'mele e ka bonts'a hore o na le sebete se ruruhileng kapa spleen, kapa matšoao a tšenyo ea methapo.

Mohato oa pele oa ho fumana amyloidosis e lokela ho ba liteko tsa mali le moroto ho batla liprotheine tse sa tloaelehang.

Liteko tse ling li latela matšoao a hau le setho se ka amehang. Liteko tse ling li kenyelletsa:

• Mpa ea mpa ea mpa ho lekola sebete le spleen
• Liteko tsa pelo, joalo ka ECG, kapa echocardiogram, kapa MRI
• Liteko tsa ts'ebetso ea liphio ho lekola matšoao a ho hloleha ha liphio (nephrotic syndrome)

Liteko tse ka thusang ho netefatsa ts'oaetso li kenyelletsa:

• Mpeng ea mafura a mpa
• Tlhahiso ea moko oa masapo
• Tlhatlhobo ea mesifa ea pelo
• Sekhahla sa mucosa biopsy

Kalafo e ka kenyelletsa:

• Chemotherapy
• Ho kenyelletsa sele ea stem
• Ho kenyelletsa 'mele

Haeba boemo bo bakoa ke lefu le leng, lefu leo ​​le lokela ho phekoloa hampe. Sena se ka ntlafatsa matšoao kapa sa liehisa lefu ho mpefala. Mathata a kang ho hloleha ha pelo, ho hloleha ha liphio le mathata a mang ka linako tse ling a ka phekoloa, ha ho hlokahala.

Hore na o sebetsa hantle hakae ho latela hore na ke litho life tse amehang. Ho ameha ha pelo le liphio ho ka lebisa ho senyeheng ha setho le lefu. Amyloidosis ea 'mele ka bophara e ka lebisa lefung pele ho lilemo tse 2.

Bitsa mofani oa hau haeba u e-na le matšoao a lefu lena. Hape letsetsa haeba u fumanoe u na le lefu lena mme u na le:

• Motsoako o fokotsehileng
• Ho phefumoloha ho thata
• Ho ruruha ha maqaqailana kapa dikarolo tse ding tsa mmele tse sa foleng

Ha ho na thibelo e tsebahalang bakeng sa amyloidosis ea mantlha.

Amyloidosis - ea mantlha; Mokelikeli oa leseli la immunoglobulin amyloidosis; Tsamaiso ea mantlha ea amyloidosis

• Amyloidosis ea menoana
• Amyloidosis ea sefahleho

Gertz MA, Buadi FK, Lacy MQ, Hayman SR. Immunoglobulin light-chain amyloidosis (mathomo amyloidosis). Ka: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Melao-motheo le Tloaelo ea Motheo. La 7th. Philadelphia, PA: Elsevier; 2018: khaolo ea 88.

Hawkins PN. Amyloidosis.Ho: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, bahlophisi. Rheumatology. La 7th. Philadelphia, PA: Elsevier; 2019: khaolo ea 177.