Khaello ea alpha-1 ea antitrypsin

Ho haella ha Alpha-1 antitrypsin (AAT) ke boemo boo 'mele o sa etsang AAT e lekaneng, protheine e sireletsang matšoafo le sebete tšenyo. Boemo bo ka lebisa ho COPD le lefu la sebete (cirrhosis).

AAT ke mofuta oa protheine e bitsoang protease inhibitor. AAT e entsoe sebeteng 'me e sebetsa ho sireletsa matšoafo le sebete.

Ho haelloa ke AAT ho bolela hore ha ho na protheine e lekaneng 'meleng. E bakoa ke bofokoli ba lefutso. Boemo bona bo atile haholo hara batho ba Europe le Amerika Leboea ba litloholo tsa Europe.

Batho ba baholo ba nang le khaello e matla ea AAT ba tla ba le emphysema, ka linako tse ling pele ho lilemo tse 40. Ho tsuba ho ka eketsa kotsi ea emphysema mme ea etsa hore e etsahale pejana.

Matšoao a ka kenyelletsa efe kapa efe ea tse latelang:

• Phefumoloho e khutšoane ntle le boiteko, le matšoao a mang a COPD
• Matšoao a ho hloleha ha sebete
• Ho theola boima ba mmele ntle le ho leka
• Ho honotha

Tlhahlobo ea 'mele e ka senola sefuba se bōpehileng joaloka moqomo, ho hema kapa ho fokotsa melumo ea phefumoloho. Liteko tse latelang li ka thusa ho hlahloba:

• Teko ea mali ea AAT
• Likhase tsa mali tse ngata
• X-ray sefubeng
• Tlhatlhobo ea sefuba ea CT
• Ho etsa liteko tsa lefutso
• Teko ea mosebetsi oa matšoafo

Mofani oa hao oa tlhokomelo ea bophelo a ka belaela hore u na le boemo bona haeba u ka ba le:

• COPD pele ho lilemo tse 45
• COPD empa ha u e-so tsube kapa ho pepesetsoa chefo
• COPD 'me u na le nalane ea lelapa ea boemo boo
• Cirrhosis mme ha ho na lebaka le leng le ka fumanoang
• Cirrhosis mme o na le nalane ea lelapa ea lefu la sebete

Kalafo bakeng sa khaello ea AAT e kenyelletsa ho nkela protheine ea AAT e lahlehileng sebaka. Protheine e fanoa ka methapo beke le beke kapa libeke tse ling le tse ling tse 4. Sena se sebetsa hantle hanyane feela ho thibela tšenyo e ngata ea matšoafo ho batho ba se nang mafu a ho qetela. Mokhoa ona o bitsoa kalafo ea tlatsetso.

Haeba u tsuba, u hloka ho tlohela.

Mefuta e meng ea kalafo e boetse e sebelisoa bakeng sa COPD le cirrhosis.

Phetisetso ea matšoafo e ka sebelisoa bakeng sa lefu le matla la matšoafo, 'me phetisetso ea sebete e ka sebelisoa bakeng sa cirrhosis e matla.

Batho ba bang ba nang le khaello ena ba ke ke ba ba le lefu la sebete kapa la matšoafo. Haeba o tlohela ho tsuba, o ka liehisa kholo ea lefu la matšoafo.

COPD le cirrhosis li ka beha bophelo kotsing.

Mathata a khaello ea AAT a kenyelletsa:

• Bronchiectasis (tšenyo ea lifofane tse kholo)
• Lefu le sa foleng la pulmonary (COPD)
• Ho hloleha ha sebete kapa mofetše

Ikopanye le mofani oa hau haeba u hlahisa matšoao a khaello ea AAT.

Ho haelloa ke AAT; Khaello ea alpha-1 protease; COPD - alpha-1 antitrypsin khaello; Cirrhosis - alpha-1 antitrypsin khaello

• Matšoafo
• Sebopeho sa sebete

Han MK, Lazaro SC. COPD: Tlhatlhobo ea bongaka le tsamaiso. Ka: Broaddus VC, Mason RJ, Ernst JD, et al, li-eds. Buka ea Bongaka ea Phefumoloho ea Murray le Nadel. La 6th. Philadelphia, PA: Elsevier Saunders; 2016: khaolo ea 44.

Hatipoglu U, Stoller JK. khaello ea a1 -antitrypsin. Kliniki ea Sefubeng Med. 2016; 37 (3): 487-504. PMID: 27514595 www.pubmed.ncbi.nlm.nih.gov/27514595/.

Winnie GB, Boas SR. a1 -antitrypsin khaello le emphysema. Ka: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, bahlophisi. Buka ea Nelson ea Pediatrics. La 21 Ed. Philadelphia, PA: Elsevier; 2020: khaolo ea 421.