Kamoo Short-Chain Fatty Acids e Amang Bophelo bo Botle le Boima

Litaba

• Li-fatty chain tse nang le mafura ke eng?
• Mehloli ea Lijo ea Li-Fatty Chain tsa Short-Chain
• Short-Chain Fatty Acids le Mathata a Ts'oaetso
• Letšollo
• Maloetse a ho Ruruha
• Short-Chain Fatty Acids le Kankere ea Colon
• Short-Chain Fatty Acids le lefu la tsoekere
• Li-Fatty tsa ketane e khuts'oane le ho theola boima ba 'mele
• Short-Chain Fatty Acids le Bophelo ba Pelo
• Na U Lokela ho Nka Tlatsetso?
• Nka Molaetsa oa Lapeng

Li-acid tse nang le ketane e khuts'oane li hlahisoa ke libaktheria tse mosa ka maleng a hau.

Ebile, ke ona mohloli o ka sehloohong oa phepo ea lisele tse kholoneng ea hau.

Li-fat-chain fatty acids le tsona li ka bapala karolo ea bohlokoa ho bophelo bo botle le mafu.

Li ka fokotsa menyetla ea mafu a ho ruruha, mofuta oa 2 lefu la tsoekere, botenya, lefu la pelo le maemo a mang ().

Sengoliloeng sena se hlahloba hore na li-fatty chain fatty li ama bophelo bo botle joang.

Li-fatty chain tse nang le mafura ke eng?

Li-fatty chain fatty acid li mafura a nang le liathomo tse ka tlase ho 6 tsa carbon (C) ().

Li hlahisoa ha 'mala o nang le botsoalle oa libaktheria o belisa fiber ka har'a kolone ea hau,' me ke mohloli o moholo oa matla bakeng sa lisele tse kentsoeng colon ea hau.

Ka lebaka lena, ba bapala karolo ea bohlokoa ho bophelo bo botle ba colon ().

Ho sebelisoa mafura a ketane e khuts'oane haholo bakeng sa mesebetsi e meng 'meleng. Mohlala, li ka fana ka liphesente tse leshome tsa litlhoko tsa hau tsa khalori ea letsatsi le letsatsi ().

Li-fat-chain fatty acids le tsona lia ameha ho metabolism ea limatlafatsi tsa bohlokoa joalo ka carbs le mafura ().

Hoo e ka bang 95% ea li-fatty chain fatty 'meleng oa hau ke:

• Acetate (C2).
• Propionate (C3).
• Butyrate (C4).

Propionate e ameha haholo ho hlahiseng tsoekere sebeteng, ha acetate le butyrate li kenyellelitsoe ho mafura a mang a mafura le cholesterol ().

Lintho tse ngata li ama palo ea mafura a li-fatty acids ka har'a colon ea hau, ho kenyeletsoa le hore na ho na le likokoana-hloko tse kae, mohloli oa lijo le nako e nkang lijo ho tsamaea tsamaisong ea hau ea tšilo ea lijo ().

Li-acid tsa ketane tse khuts'oane li hlahisoa ha fiber e belisoa ka har'a kolone. Li sebetsa joalo ka mohloli oa matla bakeng sa lisele tse lutseng kolone.

Mehloli ea Lijo ea Li-Fatty Chain tsa Short-Chain

Ho ja lijo tse ngata tse nang le fiber, joalo ka litholoana, meroho le linaoa, ho hokahantsoe le keketseho ea li-fatty chain fatty ().

Phuputso e 'ngoe ea batho ba 153 e fumane mekhatlo e metle lipakeng tsa phepelo e phahameng ea lijo tsa limela le maemo a eketsehileng a li-fatty chain fatty lituloaneng (7).

Leha ho le joalo, bongata le mofuta oa faeba eo u e jang li ama sebopeho sa libaktheria ka maleng a hau, tse amang mafura a mafura a mangata a hlahisoang ().

Mohlala, lithuto li bontšitse hore ho ja fiber e ngata ho eketsa tlhahiso ea butyrate, ha ho fokotsa ts'ebeliso ea hau ea fiber ho fokotsa tlhahiso ().

Mefuta e latelang ea fiber e molemohali bakeng sa tlhahiso ea li-fatty chain fatty in the colon (,):

• Inulin: U ka fumana inulin ho tsoa ho artichokes, konofolo, liki, eiee, koro, rye le asparagus.
• Fructooligosaccharides (FOS): Li-FOS li fumanoa litholoana le meroho tse fapaneng, ho kenyeletsoa libanana, eiee, konofolo le asparagase.
• Starch e hanyetsanang: U ka fumana starch e sa thibeleng lithollo, harese, raese, linaoa, libanana tse tala, linaoa le litapole tse phehiloeng ebe li pholile.
• Pectin: Mehloli e metle ea pectin e kenyelletsa liapole, liapolekose, lihoete, lilamunu le tse ling.
• Lebogang Mashiane Arabinoxylan e fumanoa lithollo tsa lijo-thollo. Mohlala, ke fiber e atileng ka ho fetesisa ka hara koro ea koro, e etsang 70% ea kakaretso ea fiber.
• Gum ea marenene: Gum e ka hlahisoa ho linaoa tsa guar, e leng linaoa.

Mefuta e meng ea chisi, botoro le lebese la khomo le tsona li na le li-butyrate tse nyane.

Lijo tse nang le litlheferetsi tse phahameng, joalo ka litholoana, meroho, linaoa le lithollo tse felletseng, li khothaletsa tlhahiso ea li-acid tsa ketane e khuts'oane.

Short-Chain Fatty Acids le Mathata a Ts'oaetso

Li-acid tse nang le ketane e khuts'oane li ka ba molemo khahlano le mathata a itseng a silang lijo.

Mohlala, butyrate e na le litlamorao tse khahlano le ho ruruha ka maleng ().

Letšollo

Likokoana-hloko tsa hau tsa ka mpeng li fetola starch e sa thibeleng le pectin ho li-fatty chain fatty, 'me ho li ja ho bontšitsoe ho fokotsa letshollo ho bana (,).

Maloetse a ho Ruruha

Ulcerative colitis le lefu la Crohn ke mefuta e 'meli e meholo ea mafu a ho ruruha (IBD). Ka bobeli li khetholloa ke ho ruruha ho sa foleng ha mala.

Ka lebaka la thepa ea eona e khahlanong le ho ruruha, butyrate e sebelisitsoe ho alafa maemo ana ka bobeli.

Boithuto ho litoeba bo bonts'itse hore li-butyrate supplements li fokotsa ho ruruha ha mala, mme li-supplement tsa acetate li na le melemo e ts'oanang. Ho feta moo, maemo a tlase a li-fatty chain fatty a hokahane le ho mpefala ha ulcerative colitis (,).

Liphuputso tsa batho li boetse li fana ka maikutlo a hore li-fatty chain fatty, haholo-holo butyrate, li ka ntlafatsa matšoao a ulcerative colitis le lefu la Crohn's (,,,).

Phuputso e amanang le bakuli ba 22 ba nang le ulcerative colitis e fumane hore ho ja ligrama tse 60 tsa oat bran letsatsi le leng le le leng ka likhoeli tse 3 ho ntlafalitse matšoao ().

Phuputso e 'ngoe e nyane e fumane hore li-supplement tsa butyrate li felletse ka ntlafatso ea bongaka le phokotso ho bakuli ba lefu la Crohn's (53%).

Bakeng sa bakuli ba ulcerative colitis, enema ea li-fatty chain fatty, habeli ka letsatsi bakeng sa libeke tse 6, e thusitse ho fokotsa matšoao ka 13% ().

Mafura a ketane e khuts'oane a ka fokotsa letšollo mme a thusa ho alafa mafu a ho ruruha.

Short-Chain Fatty Acids le Kankere ea Colon

Li-acid tse nang le ketane e khuts'oane li ka bapala karolo ea bohlokoa ho thibela le ho phekola mefuta e meng ea mofetše, haholo kankere ea colon (,,).

Liphuputso tsa Lab li bonts'a hore butyrate e thusa ho boloka lisele tsa colon li phetse hantle, e thibela kholo ea lisele tsa hlahala mme e khothaletsa tšenyo ea lisele tsa mofetše ka har'a colon (,,,).

Leha ho le joalo, mochini oa sena ha o utloisisoe hantle (,,).

Liphuputso tse 'maloa tsa ho shebella li bontša khokahano lipakeng tsa lijo tse nang le fiber e ngata le kotsi e fokotsehileng ea mofetše oa colon. Litsebi tse ngata li fana ka maikutlo a hore tlhahiso ea li-acid tsa ketane e khuts'oane e kanna ea ikarabella ho sena (,).

Liphuputso tse ling tsa liphoofolo li boetse li tlaleha kamano e ntle lipakeng tsa lijo tse nang le fiber e ngata le kotsi e fokotsehileng ea mofetše oa colon (,).

Phuputsong e 'ngoe, litoeba lijong tse nang le fiber e ngata, tseo mala a tsona a nang le libaktheria tse hlahisang butyrate, li fumane lihlahala tse fokolang ho 75% ho feta litoeba tse neng li sena baktheria ().

Ho khahlisang ke hore lijo tse nang le fiber e ngata feela - ntle le libaktheria ho etsa butyrate - li ne li se na tšireletso khahlano le mofetše oa colon. Lijo tse nang le fiber e fokolang haholo - leha e na le libaktheria tse hlahisang butyrate - le tsona li ne li sa sebetse ().

Sena se fana ka maikutlo a hore melemo e khahlanong le mofets'e e teng feela ha phepo e phahameng ea fiber e kopantsoe le libaktheria tse nepahetseng ka maleng.

Leha ho le joalo, lithuto tsa batho li fana ka liphetho tse fapaneng. Tse ling li bonts'a khokahano lipakeng tsa lijo tse nang le fiber e ngata le ho fokotsa kotsi ea mofetše, ha ba bang ba sa fumane sehokelo (,,,).

Leha ho le joalo lithuto tsena ha lia ka tsa sheba libaktheria tsa ka mpeng, 'me phapang ea batho ka maleng a libaktheria e ka bapala karolo.

Li-acid tsa ketane tse khuts'oane li bontšitsoe hore li itšireletsa khahlanong le mofetše oa colon lipatlisisong tsa liphoofolo le tsa laboraka. Leha ho le joalo, lipatlisiso tse ling lia hlokahala.

Short-Chain Fatty Acids le lefu la tsoekere

Tlhahlobo ea bopaki e tlalehile hore butyrate e ka ba le litlamorao tse ntle liphoofolong le bathong ba nang le mofuta oa 2 lefu la tsoekere ().

Tlhahlobo e tšoanang e boetse e totobalitse hore ho bonahala ho na le ho se leka-lekane ha likokoana-hloko tsa mala ho batho ba nang le lefu la tsoekere (,).

Li-acid tsa ketane tse khuts'oane li bontšitsoe ho eketsa ts'ebetso ea enzyme sebeteng le mesifa ea mesifa, e hlahisang taolo e ntle ea tsoekere ea mali (,,).

Lithutong tsa liphoofolo, li-acetate le propionate li tlatsetsa tsoekere e maling ka litoeba tsa lefu la tsoekere le likhoto tse tloaelehileng (,,).

Leha ho le joalo ho na le lithuto tse fokolang tse amang batho, 'me liphetho li tsoakane.

Phuputso e 'ngoe e fumane hore li-supplement tsa propionate li fokotsa tsoekere ea mali, empa phuputso e' ngoe e fumane hore li-fat-chain tse nang le mafura a mangata ha li ame taolo ea tsoekere maling ho batho ba phetseng hantle (,).

Liphuputso tse 'maloa tsa batho le tsona li tlalehile mekhatlo e pakeng tsa fiber e belang le taolo e ntlafalitsoeng ea tsoekere ea mali le kutloisiso ea insulin (,).

Leha ho le joalo phello ena hangata e bonoa feela ho batho ba nonneng haholo kapa ba hanang insulin, eseng ho batho ba phetseng hantle (,,).

Li-acid tse mafura a ketane e khuts'oane li bonahala li thusa ho laola maemo a tsoekere maling, haholo ho batho ba nang le lefu la tsoekere kapa insulin.

Li-Fatty tsa ketane e khuts'oane le ho theola boima ba 'mele

Sebopeho sa likokoana-hloko tse ka mpeng se ka ama ho monya limatlafatsi le taolo ea matla, ka hona sa susumetsa nts'etsopele ea botena (,).

Boithuto bo bonts'itse hore li-fatty chain fatty li boetse li laola metabolism ea mafura ka ho eketsa ho chesa mafura le ho fokotsa polokelo ea mafura ().

Ha sena se etsahala, bongata ba mafura a mafura a maling a fokotsehile, hape ho ka thusa ho itšireletsa khahlanong le boima ba 'mele (,,,).

Liphuputso tse 'maloa tsa liphoofolo li hlahlobile phello ena. Kamora kalafo ea libeke tse 5 ka butyrate, litoeba tse nonneng li lahlile 10.2% ea boima ba 'mele ba bona ba pele, mme mafura a' mele a fokotsoe ka 10%. Ka likhoto, li-acetate li fokotsa polokelo ea mafura (,).

Leha ho le joalo, bopaki bo hokahanyang mafura a ketane e khuts'oane le tahlehelo ea boima bo thehiloe haholo lithutong tsa liphoofolo le li-test-tube.

Liphuputso tsa liphoofolo le li-tube-test li bonts'a hore li-fatty chain fatty li ka thusa ho thibela le ho phekola botenya. Leha ho le joalo, lithuto tsa batho lia hlokahala.

Short-Chain Fatty Acids le Bophelo ba Pelo

Liphuputso tse ngata tsa ho shebella li hokahantse lijo tse nang le fiber e ngata ho fokotsa kotsi ea lefu la pelo.

Leha ho le joalo, matla a mokhatlo ona hangata a ipapisitse le mofuta oa fiber le mohloli ().

Ho batho, ho ja fiber ho boetse ho hokahantsoe le ho fokotsa ho ruruha ().

Le leng la mabaka ao fiber e fokotsang kotsi ea lefu la pelo e kanna ea ba ka lebaka la tlhahiso ea mafura a liketane tse khutšoane colon (,,).

Liphuputso liphoofolong le bathong li tlalehile hore li-fatty chain fatty acid li fokolitse li-cholesterol (,,,,).

Ho nahanoa hore Butyrate e sebelisana le liphatsa tsa lefutso tse etsang cholesterol, mohlomong ho fokotsa tlhahiso ea k'holeseterole ().

Ka mohlala, tlhahiso ea k'holeseterole e fokotsehile ka har'a likhoto tse fuoeng litlatsetso tsa propionate. Acetic acid e boetse e fokotsa maemo a k'holeseterole ho likhoto (,,).

Phello e ts'oanang e ile ea bonoa ho batho ba batenya haholo, joalo ka ha acetate ea asene e fokotsa palo ea k'holeseterole e feteletseng maling a mali ().

Mafura-ketane a mafura a mangata a ka fokotsa kotsi ea lefu la pelo ka ho fokotsa ho ruruha le ho thibela tlhahiso ea k'holeseterole.

Na U Lokela ho Nka Tlatsetso?

Li-acid tse nang le mafura a mangata li fumaneha hangata e le letsoai la asiti.

Hangata tsena li bitsoa sodium, potasiamo, calcium kapa magnesium butyrate. Li fumaneha habonolo inthaneteng kapa li-rekeng.

Leha ho le joalo, li-supplement e kanna ea se be eona tsela e ntle ea ho eketsa maemo a hau a li-fatty chain fatty acids. Lisebelisoa tsa Butyrate lia monngoa pele li fihla colon, hangata ka maleng a manyane, ho bolelang hore melemo eohle ea lisele tsa colon e tla lahleha.

Ntle le moo, ho na le bopaki bo fokolang haholo ba mahlale mabapi le katleho ea litlatsetso tsa mafura a ketane e khuts'oane.

Butyrate e fihla hantle ho colon ha e belisitsoe ka fiber. Ka hona, ho eketsa palo ea lijo tse nang le fiber e ngata lijong tsa hau e kanna ea ba tsela e betere ho feta ea ho ntlafatsa li-acid tsa mafura a ketane e khuts'oane.

Ho ja lijo tse nang le fiber e ngata ke tsela e molemohali ea ho eketsa maemo a asiti e khutšoane ea mafura, kaha li-supplement li ananeloa pele li fihla colon.

Nka Molaetsa oa Lapeng

Ka lebaka la thepa ea bona e khahlanong le ho ruruha le e khahlanong le mofets'e, ho kanna ha etsahala hore mafura a liketane tse khuts'oane a na le litlamorao tse ngata tse ntle 'meleng oa hau.

Ho na le bonnete ba hore: ho hlokomela libaktheria tsa hau tse botsoalle ho ka lebisa ho melemo e mengata ea bophelo bo botle.

Tsela e molemohali ea ho fepa libaktheria tse ntle ka maleng a hao ke ho ja lijo tse ngata tse nang le fiber e ngata haholo.