Chimerism ke eng, mefuta le mokhoa oa ho khetholla

Litaba

• Mefuta ea chimerism
• 1. Chimerism ea tlhaho
• 2. Chimerism ea maiketsetso
• 3. Microquimerismo
• 4. Mafahla chimerism
• Tsela ea ho khetholla

Chimerism ke mofuta oa phetoho e sa tloaelehang ea liphatsa tsa lefutso eo ho eona ho nang le lisebelisoa tse peli tse fapaneng tsa lefutso, tse ka bang tsa tlhaho, tse etsahalang nakong ea bokhachane, ka mohlala, kapa ka lebaka la phetisetso ea lisele tsa hematopoietic, moo lisele tsa lisele tsa bafani tse kenngoeng teng li ananeloa ke moamoheli, ka boteng bo kopaneng ba lisele tse nang le lifaele tse fapaneng tsa lefutso.

Ho nkuoa e le chimerism ha boteng ba batho ba babeli kapa ho feta ba lisele tse fapaneng tsa lefutso tse nang le semelo se fapaneng bo netefalitsoe, ho fapana le se etsahalang ka mosaic, eo ho sa tsotelehe bongata ba lisele bo fapaneng ka liphatsa tsa lefutso, li nang le tšimoloho e ts'oanang. Ithute haholoanyane ka mosaic.

Mefuta ea chimerism

Boreleli ha boa tloaeleha har'a batho 'me bo ka bonoa habonolo liphoofolong. Leha ho le joalo ho ntse ho ka ba teng hore ho na le chmerism har'a batho, mefuta ea mantlha ke:

1. Chimerism ea tlhaho

Chimerism ea tlhaho e etsahala ha mahe a emolisitsoeng a 2 kapa ho feta a kopana, a etsa o le mong. Kahoo, lesea le entsoe ka lintho tse 2 kapa ho feta tse fapaneng tsa lefutso.

2. Chimerism ea maiketsetso

Ho etsahala ha motho a fuoa tšelo ea mali kapa phetisetso ea moko oa masapo kapa lisele tsa hematopoietic tse tsoang ho motho e mong, lisele tsa bafani li monya mmele. Boemo bona bo ne bo tloaelehile nakong e fetileng, leha ho le joalo kajeno kamora ho kenya motho e mong ho lateloa mme o etsa liphekolo tse ling tse thibelang ho kenella ka ho sa feleng ha lisele tsa bafani, ntle le ho netefatsa kamohelo e ntle ea 'mele.

3. Microquimerismo

Mofuta ona oa chimerism o hlaha nakong ea bokhachane, moo mosali a monyang lisele tse ling tsa lesea kapa lesea le monyang lisele tse tsoang ho mme, tse hlahisang lisebelisoa tse peli tse fapaneng tsa lefutso.

4. Mafahla chimerism

Mofuta ona oa ho chesa o etsahala ha nakong ea bokhachane ba mafahla, lesea le le leng le shoa ebe lesea le leng le monya lisele tse ling tsa lona. Kahoo, lesea le hlahang le na le liphatsa tsa lona tsa lefutso le lefutso la ngoan'abo.

Tsela ea ho khetholla

Boreleli bo ka tsebahatsoa ka litšobotsi tse ling tseo motho a ka li bonts'ang e le libaka tsa 'mele tse nang le' mala o mongata, mahlo a nang le mebala e fapaneng, ketsahalo ea mafu a itšireletsang mafung a amanang le letlalo kapa tsamaiso ea methapo le thobalano. litšobotsi tse fapaneng tsa thobalano le mekhoa ea chromosomal, e etsang hore ho be thata ho khetholla motho eo e le oa bong ba monna kapa ba mosali.

Ntle le moo, chimerism e khetholloa ka liteko tse lekolang lisebelisoa tsa lefutso, DNA, le boteng ba lipara tse peli kapa ho feta tsa DNA liseleng tse khubelu tsa mali, ka mohlala, li ka netefatsoa. Ntle le moo, ha ho sebelisoa chimerism kamora ho fetisoa ha hematopoietic stem cell, ho khonahala ho tseba phetoho ena ka tlhahlobo ea liphatsa tsa lefutso e lekolang li-marker tse tsejoang e le li-STR, tse khonang ho khetholla lisele tsa moamoheli le mofani.