Liketane Tsa Leseli Tsa Mahala

Litaba

• Teko ea liketane tsa lebone la mahala ke eng?
• E sebelisetsoa eng?
• Hobaneng ha ke hloka teko ea mahala ea liketane tsa mabone?
• Ho etsahalang nakong ea liteko tsa mahala tsa liketane tsa mabone?
• Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?
• Na ho na le likotsi tsa liteko tsa mahala tsa liketane tsa mabone?
• Liphetho li bolelang?
• Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea mahala ea liketane tsa mabone?
• Litšupiso

Teko ea liketane tsa lebone la mahala ke eng?

Liketane tse bobebe ke liprotheine tse entsoeng ke lisele tsa plasma, mofuta oa sele e tšoeu ea mali. Lisele tsa Plasma li boetse li etsa li-immunoglobulin (antibodies). Li-immunoglobulin li thusa ho sireletsa 'mele khahlanong le mafu le tšoaetso. Li-immunoglobulin li thehoa ha liketane tse bobebe li hokahana le liketane tse boima, mofuta o mong oa protheine. Ha liketane tse bobebe li hokahana le liketane tse boima, li tsejoa e le tlamiloe liketane tse bobebe.

Ka tloaelo, lisele tsa lero la mali li etsa palo e nyane ea liketane tse eketsehileng tsa khanya tse sa tlangoeng ka liketane tse boima. Ho e-na le hoo, ba lokolloa hore ba kene maling. Liketane tsena tse sa hokeloang li tsejoa e le mahala liketane tse bobebe.

Ho na le mefuta e 'meli ea liketane tse bobebe: lambda le kappa leseli la liketane. Teko ea liketane tsa lebone la mahala e lekanya boholo ba liketane tse sa lefelloeng tsa lambda le kappa maling. Haeba boholo ba liketane tsa mabone a mahala li phahame kapa li le tlase ho feta tse tloaelehileng, ho ka bolela hore o na le bothata ba lisele tsa lero la mali. Tsena li kenyelletsa myeloma e mengata, mofetše oa lisele tsa plasma, le amyloidosis, boemo bo bakang liprotheine tse ngata tse kotsi lithong tse fapaneng le liseleng.

Mabitso a mang: kappa / lambda ratio ea mahala, kappa / lambda palo ea mahala ea mahala, freelite, kappa le lambda mabone a mabone a mahala, liketane tse bobebe tsa immunoglobulin.

E sebelisetsoa eng?

Ho sebelisoa liteko tsa mahala tsa liketane tsa leseli ho thusa ho hlahloba kapa ho lekola mathata a sele ea mali.

Hobaneng ha ke hloka teko ea mahala ea liketane tsa mabone?

U kanna oa hloka teko ena haeba u na le matšoao a lefu la sele ea mali. Ho latela hore na o na le bothata ba mali ba mali le hore na ke litho life tse amehang, matšoao a hau a ka kenyelletsa:

• Bohloko ba masapo
• Mokhathala
• Ho ba lerootho kapa ho hlohlona matsohong le maotong
• Ho ruruha ha leleme
• Matheba a maputsoa letlalong

Ho etsahalang nakong ea liteko tsa mahala tsa liketane tsa mabone?

Ngaka ea tlhokomelo ea bophelo e tla nka sampole ea mali mothapong o letsohong la hao, e sebelisa nale e nyane. Kamora hore nalete e kenngoe, ho tla bokelloa mali a manyane ka har'a pompo ea liteko. U ka ikutloa u hlaba hanyane ha nale e kena kapa e tsoa. Hangata hona ho nka nako e ka tlase ho metsotso e mehlano.

Na ke tla hloka ho etsa eng kapa eng ho itokisetsa tlhahlobo?

Ha o hloke litokisetso tse khethehileng bakeng sa teko ea mahala ea liketane tsa mabone.

Na ho na le likotsi tsa liteko tsa mahala tsa liketane tsa mabone?

Ho na le kotsi e nyane haholo ea ho etsa tlhahlobo ea mali. U kanna oa ba le mahlaba a fokolang kapa ho longoa moo nale e kentsoeng teng, empa matšoao a mangata a fela kapele.

Liphetho li bolelang?

Liphetho tsa hau li tla bontša bokaalo ba liketane tsa mabone tsa lambda le kappa tsa mahala. E tla fana ka papiso lipakeng tsa tsena tse peli. Haeba liphetho tsa hau li ne li sa tloaeleha, ho ka bolela hore o na le lefu la sele ea mali, joalo ka:

• Myeloma e mengata
• Amyloidosis
• MGUS (monoclonal gammopathy ea bohlokoa bo sa tsejoeng). Ena ke boemo boo ho bona u nang le liprotheine tse sa tloaelehang. Hangata ha e bake mathata kapa matšoao, empa ka linako tse ling e fetoha myeloma e mengata.
• Waldenstrom macroglobulinemia (WM), mofetše oa lisele tse tšoeu tsa mali. Ke mofuta oa non-Hodgkin lymphoma.

Ithute haholoanyane ka liteko tsa laboratori, libaka tsa litšupiso, le liphetho tsa kutloisiso.

Na ho na le eng kapa eng eo ke hlokang ho e tseba ka tlhahlobo ea mahala ea liketane tsa mabone?

Hangata liteko tsa liketane tsa mabone a lebone li laeloa ka liteko tse ling, ho kenyeletsoa le tlhahlobo ea mali ea immunofixation, ho thusa ho netefatsa kapa ho felisa tlhahlobo.

Litšupiso

1. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2019. Liteko tsa ho Fumana Multiple Myeloma; [e ntlafalitsoeng 2018 Feb 28; e qotsitsoeng ka la 2019 Dec 21]; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/testing.html
2. Mokhatlo oa American Cancer [Inthanete]. Atlanta: Mokhatlo oa Amerika oa Kankere Inc .; c2019. Waldenstrom Macroglobulinemia ke eng ?; [e ntlafalitsoeng 2018 Jul 29; e qotsitsoeng ka la 2019 Dec 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.org/cancer/waldenstrom-macroglobulinemia/about/what-is-wm.html
3. Mokhatlo oa Amerika oa Hematology [Marang-rang]. Washington DC: Mokhatlo oa Amerika oa Hematology; c2019. Myeloma; [e qotsitsoeng ka la 9 Phato 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.hematology.org/Patients/Cancers/Myeloma.aspx
4. Mokhatlo oa Machaba oa Myeloma [Inthanete]. North Hollywood (CA): Mokhatlo oa Machaba oa Myeloma; Ho utloisisa liteko tsa Freelite le Hevylite; [e qotsitsoeng ka la 9 Phato 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.myeloma.org/sites/default/files/resource/u-freelite_hevylite.pdf
5. Liteko tsa Lab Marang-rang [Inthaneteng]. Washington DC: Mokhatlo oa Amerika oa Clinical Chemistry; c2001–2019. Liketane Tsa Leseli Tsa Serum Free; [e ntlafalitsoeng 2019 Oct 24; e qotsitsoeng ka la 2019 Dec 21]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://labtestsonline.org/tests/serum-free-light-chains
6. Mayo Clinic [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1998–2019. Gammopathy ea monoclonal ea bohlokoa bo sa lekanyetsoang (MGUS): Matšoao le lisosa; 2019 Motšeanong 21; [e qotsitsoeng ka la 9 Phato 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/syc-20352362
7. Mayo Clinic: Mayo Medical Laboratories [Inthaneteng]. Motheo oa Mayo oa Thuto ea Bongaka le Patlisiso; c1995–2019. Teko ea Teko: FLCP: Liketane tsa Leseli tsa Immunoglobulin, Serum: Tleliniking le Tlhalosong; [e qotsitsoeng ka la 2019 Phato 21; [hoo e ka bang li-skrini tse 4]. E fumaneha ho tsoa ho: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/84190
8. Mokhatlo oa Naha oa Kankere [Inthanete]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho Plasma Cell Neoplasms (Ho kenyeletsoa Multiple Myeloma) Treatment (PDQ®) –Patient Version; [e ntlafalitsoeng 2019 Nov 8; e qotsitsoeng ka la 2019 Dec 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq
9. National Heart, Lung, le Setsi sa Mali [Internet]. Bethesda (MD): Lefapha la Bophelo le Litšebeletso tsa Botho la U.S. Liteko tsa Mali; [e qotsitsoeng ka la 9 Phato 21]; [li-skrini tse ka bang 3]. E fumaneha ho tsoa ho: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. Setsi sa Bongaka sa Rochester [Internet]. Rochester (NY): Setsi sa Bongaka sa Univesithi ea Rochester; c2019. Health Encyclopedia: Liketane tsa Leseli la mahala (Mali); [e qotsitsoeng ka la 9 Phato 21]; [li-skrini tse ka bang 2]. E fumaneha ho tsoa ho: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=serum_free_light_chains

Tlhahisoleseling e fumanehang sebakeng sena sa marang-rang ha ea lokela ho sebelisoa ho nka sebaka sa tlhokomelo ea bongaka le likeletso. Ikopanye le mofani oa tlhokomelo ea bophelo haeba u na le lipotso ka bophelo ba hau.