Na migraine e ka ba liphatseng tsa hau tsa lefutso?

Litaba

• Na migraine e ka ba liphatsa tsa lefutso?
• Phuputso e reng?
• Liphetoho tsa lefutso tse amanang le migraine
• Liphetoho tsa Gene tse amanang le migraine
• Na mefuta e meng ea migraine e na le kamano e matla ho feta tse ling?
• Ho ba le lefutso le amanang le migraine ho ka u thusa joang?
• Nako ea ho bona ngaka
• Ke mekhoa efe e tloaelehileng ea kalafo?
• Meriana ea matšoao a bohloko a migraine
• Meriana e thibelang litlhaselo tsa migraine
• Phekolo e kopaneng
• Ntlha ea bohlokoa

Migraine ke boemo ba methapo bo amang batho ba ka bang limilione tse 40 United States.

Hangata litlhaselo tsa migraine li hlaha ka lehlakoreng le leng la hlooho. Ka linako tse ling li ka etelloa pele kapa tsa tsamaea le pherekano e bonts'ang kapa ea kutlo e tsejoang e le aura.

Matšoao a mang, joalo ka ho nyekeloa ke pelo, ho hlatsa le ho ba le kutlo e bobebe, a ka ba teng nakong ea tlhaselo ea migraine.

Le ha ho sa tsejoe sesosa sa 'nete sa migraine, ho lumeloa hore maemo a tikoloho le liphatsa tsa lefutso a bapala karolo ea boemo bona. Ka tlase, re tla shebisisa kamano pakeng tsa migraine le liphatsa tsa lefutso.

Na migraine e ka ba liphatsa tsa lefutso?

DNA ea hau, e nang le liphatsa tsa hau tsa lefutso, e kentsoe lipara tse 23 tsa li-chromosome. U rua chromosome e le 'ngoe ho' m'ao 'me e' ngoe e tsoa ho ntate oa hau.

Jini ke karolo ea DNA e fanang ka leseli la hore na u ka etsa liprotheine tse fapaneng joang 'meleng oa hau.

Ka linako tse ling liphatsa tsa lefutso li ka ba le liphetoho, 'me liphetoho tsena li ka baka kapa tsa beha motho maemong a itseng a bophelo bo botle. Liphetoho tsena tsa liphatsa tsa lefutso li ka fetisoa ho tloha ho motsoali ho ea ho ngoana.

Liphetoho tsa lefutso kapa ho se tšoane ho 'nile ha amahanngoa le migraine. Ha e le hantle, ho hakanngoa hore batho ba fetang halofo ea batho ba nang le migraine ba na le bonyane setho se seng sa lelapa se nang le bothata bona.

Phuputso e reng?

Ha re keneng ka botebo ho seo bafuputsi ba ithutang sona ka lefutso le migraine.

Liphetoho tsa lefutso tse amanang le migraine

E ka 'na eaba u utloile ka lipatlisiso tse ling litabeng tse mabapi le liphetoho tse fapaneng tsa liphatsa tsa lefutso tse amanang le migraine. Mehlala e meng e kenyelletsa:

• EA-188. Jini ena e kenya protheine e bitsoang TRESK, e amanang le litsela tsa bohloko mme e fumanoa libakeng tsa methapo e amanang le migraine. Phetoho e khethehileng ho EA-188 e bile e amanang le migraine le aura.
• CKIdelta. Jini ena e kenyelletsa enzyme e nang le mesebetsi e mengata kahare ho 'mele, e' ngoe ea eona e amahanngoa le potoloho ea hau ea ho robala. Ho latela phuputso ea 2013, liphetoho tse ikhethang ho CKIdelta li ne li amahanngoa le migraine.

Liphetoho tsa Gene tse amanang le migraine

Ke habohlokoa ho bontša hore litlhaselo tse ngata tsa migraine li lumeloa hore ke polygenic. Sena se bolela hore liphatsa tsa lefutso tse ngata li kenya letsoho boemong bona. Sena se bonahala e le ka lebaka la liphapang tse nyane tsa lefutso tse bitsoang single-nucleotide polymorphisms (SNPs).

Liphuputso tsa liphatsa tsa lefutso li supile libaka tse fetang 40 tsa liphatsa tsa lefutso ka mefuta e meng e amanang le mefuta e tloaelehileng ea migraine. Libaka tsena hangata li hokahane le lintho tse kang ho lisa cellular le methapo ea kutlo kapa ts'ebetso ea methapo ea methapo ea mali.

U le mong, mefuta ena e ka ba le phello e nyane. Leha ho le joalo, ha bongata ba tsona bo bokellana, bo ka kenya letsoho kholisong ea migraine.

Phuputso ea 2018 ea malapa a 1,589 a nang le migraine e fumane "mojaro" o eketsehileng oa mefuta ena ea liphatsa tsa lefutso ha e bapisoa le batho ka kakaretso.

Ho na le mabaka a fapaneng a lefutso a khethollang likarolo tse itseng tsa migraine. Ho ba le nalane e matla ea migraine ho ka eketsa menyetla ea ho ba le:

• migraine le aura
• litlhaselo tsa migraine khafetsa
• lilemo tsa pele tsa ho qaleha ha migraine
• matsatsi a mangata ha o tlameha ho sebelisa meriana ea migraine

Na mefuta e meng ea migraine e na le kamano e matla ho feta tse ling?

Mefuta e meng ea migraine e na le mokhatlo o tummeng oa liphatsa tsa lefutso. Mohlala oa sena ke hemiplegic migraine ea lelapa (FHM). Ka lebaka la mokhatlo ona o tsebahalang, FHM e ithutiloe haholo mabapi le liphatsa tsa lefutso tsa migraine.

FHM ke mofuta oa migraine o nang le aura eo hangata e nang le lilemo tsa pele ho feta mefuta e meng ea migraine. Hammoho le matšoao a mang a tloaelehileng aura, batho ba nang le FHM le bona ba na le bofokoli kapa bofokoli ka lehlakoreng le leng la 'mele.

Ho na le liphatsa tsa lefutso tse tharo tse fapaneng tse tsebahalang hore li amahanngoa le FHM. Ke:

• CACNA1A
• EA-K02
• SCN1A

Phetoho e 'ngoe ea liphatsa tsena tsa lefutso e ka ama tšebetso ea lisele tsa methapo ea kutlo, e ka bakang tlhaselo ea migraine.

FHM e futsitsoe ka mokhoa o ka sehloohong oa likoloi. Sena se bolela hore o hloka kopi e le 'ngoe feela ea lefutso le fetotsoeng ho ba le boemo bona.

Ho ba le lefutso le amanang le migraine ho ka u thusa joang?

E kanna ea utloahala e se ea bohlokoa, empa ho ba le lefutso le amanang le migraine ho ka ba molemo. Ke hobane o ka fumana leseli la bohlokoa le tšehetso ho tsoa ho litho tsa lelapa la hau tse utloisisang boemo bona.

Tlhahisoleseling e tsoang ho litho tsa lelapa la hau e ka bang molemo bakeng sa boiphihlelo ba hau ba migraine e kenyelletsa:

• seo lisosa tsa bona tsa migraine li leng sona
• matšoao a khethehileng ao ba bang le ona
• kalafo kapa meriana e thusang ho sebetsana ka katleho le matšoao a bona a migraine
• hore na litlhaselo tsa bona tsa migraine li fetohile khafetsa, matla, kapa ka litsela tse ling bophelong bohle ba bona
• lilemo tseo ba qalileng ho ba le migraine ka tsona

Nako ea ho bona ngaka

Haeba u e-na le matšoao a lumellanang le migraine, etsa kopano le ngaka ea hau. Matšoao a tlhaselo ea migraine a kenyelletsa:

• bohloko bo otlang pelo, hangata lehlakoreng le leng la hlooho ea hau
• ho nyekeloa le ho hlatsa
• kutloisiso ea leseli
• kutloisiso ea molumo
• matšoao aura, a ka etellang tlhaselo ea migraine pele mme a ka kenyelletsa:
  • ho bona mahlaseli a khanyang
  • ho thatafalloa ho bua
  • maikutlo a ho fokola kapa ho ba shoele ka lehlakoreng le leng la sefahleho sa hao kapa setho sa mmele

Ka linako tse ling bohloko ba hlooho e ka ba sesupo sa ts'ohanyetso ea bongaka. Fumana tlhokomelo ea meriana kapele bakeng sa hlooho e bohloko e latelang:

• e tla ka tšohanyetso 'me e matla
• e etsahala ka mora ho lemala hloohong
• e hlaha ka matšoao a kang molala o thata, pherekano kapa ho ba shohlo
• e tšoarella nako e telele ebile e ea mpefala kamora ho ikitlaetsa

Ke mekhoa efe e tloaelehileng ea kalafo?

Hangata migraine e phekoloa ka meriana. Ho na le mefuta e 'meli ea meriana ea migraine:

• tse nolofatsang matšoao a hlohlona a migraine
• tse thusang ho thibela tlhaselo ea migraine ho etsahala

Hape ho na le mekhoa e meng ea ho kopanya e ka sebetsang. Re tla hlahloba mofuta o mong le o mong oa kalafo ka botlalo haholoanyane ka tlase.

Meriana ea matšoao a bohloko a migraine

U tloaetse ho noa meriana ena hang ha u qala ho utloa matšoao a tlhaselo ea aura kapa migraine. Mehlala e kenyelletsa:

• Meriana ea bohloko ea ho feta tekano. Tsena li kenyelletsa li-NSAID tse kang ibuprofen (Advil, Motrin), naproxen (Aleve) le aspirin. Acetaminophen (Tylenol) le eona e ka sebelisoa.
• Litlhapi. Ho na le mefuta e mengata ea li-triptan. Lithethefatsi tsena li thusa ho thibela ho ruruha le ho tiisa methapo ea mali, ho imolla bohloko. Mehlala e meng e kenyelletsa sumatriptan (Imitrex), eletriptan (Relpax), le rizatriptan (Maxalt).
• Li-alkaloids tse fosahetseng. Lithethefatsi tsena li sebetsa ka tsela e ts'oanang le li-triptan. Ba ka fuoa ha kalafo ka li-triptan e sa sebetse. Mohlala o mong ke dihydroergotamine (Migranal).
• Litšila. Leqhubu lena le lecha la meriana ea migraine le thibela peptide e sebelisanang le ho ruruha.
• Ditetsane. Lelapa la lipale tsa pholoso, lithane li ts'oana le li-triptan empa li ka sebelisoa ho batho ba nang le nalane ea lefu la pelo le stroke, kaha li-triptan li ka eketsa kotsi ea mathata a pelo.

Meriana e thibelang litlhaselo tsa migraine

Ngaka ea hau e ka u fa e 'ngoe ea meriana ena haeba u e-na le migraine khafetsa kapa e matla. Mehlala e meng ke ena:

• Li-anticonvulsants. Meriana ena e qapiloe qalong ho thusa ho sebetsana le ho oa. Mehlala e kenyelletsa topiramate (Topamax) le valproate.
• Meriana ea khatello ea mali. Tsena li ka kenyelletsa beta-blockers kapa calcium blockers.
• Meriana e loantšang khatello ea maikutlo. Amitriptyline, tricyclic e loantšang khatello ea maikutlo, e ka sebelisoa.
• Li-inhibitors tsa CGRP. Ena ke mofuta o mocha oa meriana e fanoang ka ente. Ke li-antibodies tse tlamang mokelikeli bokong bo khothalletsang vasodilation (ho pharalla ha methapo ea mali).
• Liente tsa Botox. Ho fumana ente ea Botox libeke tse ling le tse ling tse 12 ho ka thusa ho thibela litlhaselo tsa migraine ho batho ba bang ba baholo.

Phekolo e kopaneng

Hape ho na le liphekolo tse fapaneng tse ka sebetsang bakeng sa migraine, joalo ka:

• Mekhoa ea boikhathollo. Ho imeloa kelellong ke sesosa se tloaelehileng sa migraine. Mekhoa ea boikhathollo e ka u thusa ho fokotsa khatello ea maikutlo. Mehlala e kenyelletsa yoga, ho thuisa, ho ikoetlisa le ho phomola ha mesifa.
• Phekolo ea matsoho. Ho faola ka linalete ho kenyelletsa ho kenya linalete tse tšesaane lintlheng tsa khatello letlalong. Sena ho nahanoa hore se thusa ho khutlisa phallo ea matla 'meleng. Ho ka ba molemo ho fokotsa bohloko ba migraine.
• Litlama, livithamini le liminerale. Litlama le litlatsetso tse ling li ka thusa ka matšoao a migraine. Mehlala e 'maloa e kenyelletsa butterbur, magnesium le vithamine B-2.

Ntlha ea bohlokoa

Le ha bafuputsi ba fumane lisosa tse ka bakoang ke migraine, ho ntse ho na le ho hongata ho sa tsejoeng.

Leha ho le joalo, ho tsoa lipatlisisong tse seng li entsoe, ho bonahala e le motswako o rarahaneng oa maemo a tikoloho le a lefutso a bakang boemo bona.

Liphetoho liphatseng tsa lefutso tse itseng li amahanngoa le mefuta e meng ea migraine, joalo ka tabeng ea malapa a hemiplegic migraine. Leha ho le joalo, mefuta e mengata ea migraine e kanna ea ba polygenic, e bolelang ho fapana hoa liphatsa tsa lefutso tse 'maloa ho e baka.

Ho ba le nalane ea hlooho ea hlooho ea hlooho ea lelapa ho ka ba molemo ka hore o ka fumana leseli la bohlokoa ho litho tsa lelapa tse nang le boemo bo tšoanang. U ka ba ua arabela kalafo e tšoanang.

Haeba u e-na le matšoao a migraine a u thatafalletsang ho qeta letsatsi, bona ngaka ea hau ho tšohla mekhoa ea hau ea kalafo.